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Effects of e-waste exposure on biomarkers of coronary heart disease (CHD) and their associations with level of heavy metals in blood

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Abstract

Excess heavy metals increase the risk of various diseases. Electronic waste (e-waste) is a potential route to heavy metal exposure, and Taizhou is a large e-waste dismantling area in China. In this study, we acquire blood samples from residents living near an e-waste recycling area (exposed group) and other residents in a selected reference area (reference group) for a comparative study in Taizhou in December 2017. Seven heavy metals, including cobalt (Co), nickel (Ni), cadmium (Cd), tin (Sn), copper (Cu), zinc (Zn), and lead (Pb), are quantitatively determined in all blood samples. It is discovered that the levels of Co, Ni, Sn, and Pb in the exposed group are higher than those in the reference group. Additionally, two crucial biomarkers of coronary heart disease (CHD), i.e., troponin (Tn) and myeloperoxidase (MPO), and two biomarkers of oxidative stress, i.e., malondialdehyde (MDA) and 8-isoprostane (8-I), are measured. We discovered that the levels of these indicators in the exposed group are significantly higher than those in the reference group. Meanwhile, both the Spearman correlation and multiple linear regression analysis show that Ni is positively correlated with Tn, MPO, 8-I, and MDA. Hence, we hypothesize that exposure to e-waste increases the risk of CHD and that Ni is an important contributor to the initiation of the disease.

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Funding

This work was supported by grants from the National Natural Science Foundation of China (21477119).

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Authors and Affiliations

  1. State Key Laboratory of Environmental Criteria and Risk Assessment, Chinese Research Academy of Environmental Sciences, Beijing, China

    Ziye Wang, Kaibing Xue, Zhanshan Wang, Xiaojing Zhu, Chen Guo, Yan Qian, Xiaoqian Li, Zhigang Li & Yongjie Wei

  2. Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, China

    Zhigang Li & Yongjie Wei

Authors
  1. Ziye Wang
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  2. Kaibing Xue
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  3. Zhanshan Wang
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  4. Xiaojing Zhu
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  5. Chen Guo
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  6. Yan Qian
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  7. Xiaoqian Li
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  8. Zhigang Li
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  9. Yongjie Wei
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Contributions

Wang and Xue is mainly responsible for the data analysis and drafts the manuscript. Li and Wei curated the study and oversaw the coordination. All authors were involved this study and read and approved the final manuscript.

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Correspondence to Zhigang Li.

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The study was approved by the Ethics Review Committee of Peking University Health Science Center in Beijing, China.

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The authors declare no competing interests.

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Responsible Editor: Lotfi Aleya

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Wang, Z., Xue, K., Wang, Z. et al. Effects of e-waste exposure on biomarkers of coronary heart disease (CHD) and their associations with level of heavy metals in blood. Environ Sci Pollut Res 29, 49850–49857 (2022). https://doi.org/10.1007/s11356-021-15656-x

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  • DOI: https://doi.org/10.1007/s11356-021-15656-x

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