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Exploring the therapeutic potential of omega-3 fatty acids in depression

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Omega-3 fatty acids have been acknowledged for their number of holdings on an individual’s health. Not only in physical valuation but also in managing psychiatric disorders, omega-3 fatty acids have been found to be a powerful formula. It is proclaimed that depressive patients suffer anomaly with the levels of omega-3 polyunsaturated fatty acids in the body, coupled with insignificant EPA and DHA. Enhancement in brain functioning, neuronal functions, and paying attention in interacting with the brain cells are some of the additional tasks, being performed by the supplementation of omega-3 fatty acids. The leading and primary source via dietary supplementation involves the involvement of fish and fish products. These are hypothesized to be the best and dominant source for omega-3 fatty acids. Consumption of omega-3 fatty acid is well safe, that physician highly favors intake of these supplements, remarkably in the case of pregnant women. However, treating this serious life-threatening mental disorder leads to many adverse effects when treated with antidepressants. The dose range includes 1g/d to 10g/d, which is to be incorporated by the patient. It is also tested that the combination of EPA and DHA is found to be more efficacious for a person in treating and preventing depressive symptoms. Some studies verify the supplementation of omega-3 fatty acids in diet was coequally productive and successful with minimal side effects when analyzed with antidepressants. Despite these facts, much research is still needed and presently in process for long-term safety and studying the role of omega-3 fatty acids in human health.

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Conceptualization, PS and TB; writing—original draft preparation, PS and TB; figure making: SS, AS, SSN, and NS; writing—review and editing, PS, TB, and SB; proofreading, AAH and LA.

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Correspondence to Tapan Behl.

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Responsible Editor: Philippe Garrigues

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Sikka, P., Behl, T., Sharma, S. et al. Exploring the therapeutic potential of omega-3 fatty acids in depression. Environ Sci Pollut Res 28, 43021–43034 (2021).

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