Abstract
Among residents living close to agricultural fields who are potentially exposed to pesticides, pregnant women and their fetuses are of particular concern for their vulnerability to environmental chemicals. In this collaborative multicenter study, we covered a wide distribution of participants in the most important fruit production zone of north Patagonia (Argentina) to investigate whether maternal residential proximity to fruit croplands with intense pesticide applications (rural group –RG-) is associated with pregnancy complications and alterations in their newborn parameters compared to the urban population (urban group –UG-). A total of 776 pregnant women met the inclusion criteria. The percentage of threatened miscarriage was significantly higher in the RG than in the UG. The percentage of miscarriage, threat of premature labor, intrauterine fetal death, preterm premature rupture of membranes, and intrauterine growth retardation were similar in both groups. Newborn anthropometric parameters were corrected by sex and gestational age prior to statistical analysis. Length at birth and head circumference were lower in the RG than in the UG. Birth weight was similar in both groups. The percentage of head circumference less than the 5th percentile and the ponderal index were greater in the RG than in the UG. Our results suggest that proximity to pesticide applications may increase the risk of pregnancy complications and altered newborn parameters.
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The datasets used and analyzed during the current study are available from the corresponding author on reasonable request.
Abbreviations
- BW:
-
Birth weight
- CBMs:
-
Carbamates
- HC:
-
Head circumference
- LB:
-
Length at birth
- NNTs:
-
Neonicotinoids
- OPs:
-
Organophosphates
- PI:
-
Ponderal index at birth
- RG:
-
Rural group
- UG:
-
Urban group
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Acknowledgements
We thank all the women participating in this study, as well as the health agents who collaborated, especially Dr. Silvia Santa Cruz, nurse midwife Carina Romero, the staff of the Gynecology Service of the General Roca City Hospital, the Laboratory Staff of the Maternity Service and the Statistical Service of Dr. E. Accame Hospital of Allen City.
Funding
This research was conducted with the support of the Fellowship “Ramón Carrillo - Arturo Oñativia” Institutional Projects, issued by the Argentine National Ministry of Health, through the Argentine National Health Research (ECM 2010), and grants from Universidad Nacional del Comahue (I004/3) and Argentine National Agency for the Promotion of Science and Technology, FONCyT (PICT-Redes 2007-00214).
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AC: Methodology, Investigation, Data Curation, Resources
GA: Methodology, Investigation, Resources
NQ: Investigation, Data Curation
MCB: Investigation, Data Curation
SA: Investigation, Data Curation
GS: Formal analysis
GGM: Conceptualization, Writing - Review & Editing, Visualization, Supervision, Project administration, Funding acquisition
MGR: Conceptualization, Writing - Review & Editing, Visualization, Supervision, Project administration, Funding acquisition
All authors read and approved the final manuscript.
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The study protocol was approved by the ethical committee of the local Advisory Committee of Biomedical Research in Humans.
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Amalia Cecchi, Gabriel Alvarez, Natalia Quidel, María Cecilia Bertone, Guillermo Sabino, and Gladis G. Magnarelli participated in the design, execution, and analysis of the paper entitled Residential proximity to pesticide applications in Argentine Patagonia: impact on pregnancy and newborn parameter, have seen and approved the final version, and that it has neither been published nor submitted elsewhere.
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Not applicable.
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The authors declare no competing interests.
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Highlights
• Higher threatened miscarriage was the pregnancy complication associated to residential proximity to Patagonian fruit croplands with pesticide applications.
• Lower length at birth was associated to residential proximity to the fruit croplands in High Valley of Negro River, in Argentine Patagonia.
• Women living within a short distance of this agricultural field had babies with lower head circumference at birth.
• Higher ponderal index in newborns was associated to residential proximity to this fruit-growing zone.
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Cecchi, A., Alvarez, G., Quidel, N. et al. Residential proximity to pesticide applications in Argentine Patagonia: impact on pregnancy and newborn parameters. Environ Sci Pollut Res 28, 56565–56579 (2021). https://doi.org/10.1007/s11356-021-14574-2
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DOI: https://doi.org/10.1007/s11356-021-14574-2