Abstract
Lead (Pb) is a heavy metal with widespread industrial use, but it is also a widespread environmental contaminant with serious toxicological consequences to many species. Pb exposure adversely impacts the cardiovascular system in humans, leading to cardiac dysfunction, but its effects on heart failure risk remain poorly elucidated. To better understand the pathophysiological effects of Pb, we review potential mechanisms by which Pb exposure leads to cardiac dysfunction. Adverse effects of Pb exposure on cardiac function include heart failure risk, pressure overload, arrhythmia, myocardial ischemia, and cardiotoxicity. The data reviewed clearly establish that Pb exposure can play an important role in the occurrence and development of heart failure. Future epidemiological and mechanistic studies should be developed to better understand the involvement of Pb exposure in heart failure.
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Acknowledgements
We would like to thank Dr. Stanley Lin for his constructive comments and English language editing.
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ZC conducted the literature search, constructed tables using data from original manuscripts and drafted the manuscript. GC and XL proofread the manuscript. XH and XX revised and supported the manuscript. The authors read and approved the final manuscript.
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This work was supported by Guangdong Science and Technology Project for International Cooperation (2020A0505100043).
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Chen, Z., Huo, X., Chen, G. et al. Lead (Pb) exposure and heart failure risk. Environ Sci Pollut Res 28, 28833–28847 (2021). https://doi.org/10.1007/s11356-021-13725-9
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DOI: https://doi.org/10.1007/s11356-021-13725-9