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Greater toxic potency of bisphenol AF than bisphenol A in growth, reproduction, and transcription of genes in Daphnia magna

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Abstract

Limited studies were performed to evaluate the effects of bisphenol A (BPA) and bisphenol AF (BPAF) in low-trophic-level animals, such as Daphnia magna (D. magna). In this study, a 21-day standard reproductive toxicity test was carried out to assess the effects of the 2 bisphenols on development, reproduction, and transcription of genes in D. magna. The results demonstrated that only exposure to 5000 nM BPA significantly decreased the survival rate, while significant alternations were observed after exposure to 50, 500, or 5000 nM BPAF. Both the molting numbers of per female and body length of F0 generation were decreased after exposure to 500 nM BPAF, while no obvious effects were observed after treatment with lower concentrations of BPAF and BPA. Increased fecundity but decreased body length and swimming speed of F1 generation were observed after exposure to 5000 nM BPA or 500 nM BPAF. In addition, the results of the qRT-PCR showed the expressions of cyp314, ecra, ecrb, usp, vtg1, and vtg2 were significantly inhibited after exposure to 5000 nM BPA, while the expressions of cyp18a1 and vmo1 were obviously upregulated after exposure to 500 nM BPAF.

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All data generated or analyzed during this study are included in this published article (and its supplementary information files).

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Authorsicantly disturb

Sheng Chen and Xiaodong Li investigated the whole research and were major contributors in writing the manuscript. Han Li, Siliang Yuan, and Jun Li analyzed partial data in this research. Chunsheng Liu acquisited the funding and reviewed the manuscript. All authors read and approved the final manuscript.

Funding

This study was supported by the National Key R&D Program of China (2017YFF0211203).

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  1. Sheng Chen and Xiaodong Li contributed equally to this work.

Authors and Affiliations

  1. Hubei Provincial Engineering Laboratory for Pond Aquaculture, College of Fisheries, Huazhong Agricultural University, Wuhan, 430070, China

    Sheng Chen, Xiaodong Li, Han Li, Siliang Yuan, Jun Li & Chunsheng Liu

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  1. Sheng Chen
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Correspondence to Chunsheng Liu.

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Chen, S., Li, X., Li, H. et al. Greater toxic potency of bisphenol AF than bisphenol A in growth, reproduction, and transcription of genes in Daphnia magna. Environ Sci Pollut Res 28, 25218–25227 (2021). https://doi.org/10.1007/s11356-020-12153-5

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