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The effect of diazinon on blood glucose homeostasis: a systematic and meta-analysis study

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Abstract

Though evidence exists on the association between diazinon (DZN), an organophosphate pesticide, with hyperglycemia, contrasting reports also exist. Herein, we performed a systematic and meta-analysis study to address this issue. A systematic search was conducted in PubMed, Ovid Medline, Google Scholar, Scopus, and Web of Science up to April 5, 2020, searching for animal studies (rodents and fish) that assessed the impact of DZN on blood glucose concentration. The risk of bias was assessed by the SYRCLE’s RoB scale. Once each article’s quality was assessed, a random-effects meta-regression was used to pool the data into a meta-analysis. Heterogeneity between the studies was evaluated with the I square and Q test. Random-effect meta-analysis of 19 studies (I2 = 90.5%, p < 0.001) indicated low heterogeneity between the studies. DZN significantly increased blood glucose levels in the exposed versus control groups (95% CI: 2.46–4.94; Z = 5.86; p < 0.001). Subgroup analysis indicated that the effect of high-dose (3.40 (95% CI: 2.03–4.76)) DZN on changes in blood glucose was more pronounced than in the low dose (4.83 (95% CI: 1.56–8.11)). It was also ascertained that the blood glucose level was significantly higher in females (3.55 (95% CI: 2.21–4.89)) versus males (4.87 (95% CI: 0.20–9.55)) exposed to DZN. No publication bias was observed. Sensitivity analysis showed the robustness of the (standardized mean differences: 3.26–4.03). Our findings establish an association between DZN exposure and hyperglycemia in rodents and fish, which is both dose- and gender-dependent.

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References

  • Abdelkhalek NK, Eissa IA, Ahmed E, Kilany OE, El-Adl M, Da Wood MA, Hassan AM, Abdel-Daim MM (2017) Protective role of dietary Spirulina platensis against diazinon-induced oxidative damage in Nile tilapia; Oreochromis niloticus. Environ Toxicol Pharmacol 54:99–104

    CAS  Google Scholar 

  • Ahmad Z (2011) Acute toxicity and haematological changes in common carp (Cyprinus carpio) caused by diazinon exposure. Afr J Biotechnol 10:13852–13859

    CAS  Google Scholar 

  • Al-Attar AM (2015) Effect of grapeseed oil on diazinon-induced physiological and histopathological alterations in rats. Saudi J Biol Sci 22:284–292

    CAS  Google Scholar 

  • Al-Attar AM, Abu Zeid IM (2013) Effect of tea (Camellia sinensis) and olive (Olea europaea L.) leaves extracts on male mice exposed to diazinon. Biomed Res Int 2013:461415. https://doi.org/10.1155/2013/461415

    Article  Google Scholar 

  • Al-Attar AM, El Naggar MH, Al Malki EA (2018) Physiological study on the influence of some plant oils in rats exposed to a sublethal concentration of diazinon. Saudi J Biol Sci 25:786–796

    CAS  Google Scholar 

  • Al-Otaibi A, Al-Balawi H, Ahmad Z, Suliman E (2019) Toxicity bioassay and sub-lethal effects of diazinon on blood profile and histology of liver, gills and kidney of catfish, Clarias gariepinus. Braz J Biol 79:326–336

    CAS  Google Scholar 

  • Al-Shinnawy MSA (2008) Effects of orally fed diazinon on some biochemical parameters of male albino rats. Egypt J Hospital Med 33:559–568

    Google Scholar 

  • Alahyary P, Poor MI, Azarbaijani FF, Nejati V (2008) The potential toxicity of diazinon on physiological factors in male rat. Pak J Biol Sci 11:127–130

    CAS  Google Scholar 

  • Amirkabirian N, Teimouri F, Esmaily H, Mohammadirad A, Aliahmadi A, Abdollahi M (2007) Protection by pentoxifylline of diazinon-induced toxic stress in rat liver and muscle. Toxicol Mech Methods 17:215–221

    CAS  Google Scholar 

  • Anuradha R, Saraswati M, Kumar KG, Rani SH (2014) Apoptosis of beta cells in diabetes mellitus. DNA Cell Biol 33:743–748

    CAS  Google Scholar 

  • Banaee M, Sureda A, Mirvaghefi A, Ahmadi K (2011) Effects of diazinon on biochemical parameters of blood in rainbow trout (Oncorhynchus mykiss). Pestic Biochem Physiol 99:1–6

    CAS  Google Scholar 

  • Banaei M, Mir VA, Rafei G & Majazi AB 2008. Effect of sub-lethal diazinon concentrations on blood plasma biochemistry.

  • Bhatti G, Kiran R, Sandhir R (2010) Modulation of ethion-induced hepatotoxicity and oxidative stress by vitamin E supplementation in male Wistar rats. Pestic Biochem Physiol 98:26–32

    CAS  Google Scholar 

  • Ceron J, Sancho E, Ferrando M, Gutierrez C, Andreu E (1997) Changes in carbohydrate metabolism in the eel anguilla anguilla, during short-term exposure to diazinon. Toxicol Environ Chem 60:201–210

    CAS  Google Scholar 

  • Čolović M, Krstić D, Petrović S, Leskovac A, Joksić G, Savić J, Franko M, Trebše P, Vasić V (2010) Toxic effects of diazinon and its photodegradation products. Toxicol Lett 193:9–18

    Google Scholar 

  • Costa MD, Gai BM, Acker CI, Souza ACG, Bran Dão R, Nogueira CW (2012) Ebselen reduces hyperglycemia temporarily-induced by diazinon: a compound with insulin-mimetic properties. Chem Biol Interact 197:80–86

    CAS  Google Scholar 

  • El-Demerdash FM, Nasr HM (2014) Antioxidant effect of selenium on lipid peroxidation, hyperlipidemia and biochemical parameters in rats exposed to diazinon. J Trace Elem Med Biol 28:89–93

    CAS  Google Scholar 

  • El-Sameaa A, Refaat M, Aioub A, Elsobky A, Hendawy M (2018) Toxicological and histopathological effects of diazinon and sodium benzoate on the Nile tilapia fish, Oreochromis niloticus L. Zagazig J Agric Res 45:165–175

    Google Scholar 

  • Farkhondeh T, Amirabadizadeh A, Samarghandian S & Mehrpour O 2019. Impact of chlorpyrifos on blood glucose concentration in an animal model: a systematic review and meta-analysis. Environ Sci Poll Res, 1-8.

  • Ghasemzadeh J, Sinaei M, Bolouki M (2015) Biochemical and histological changes in fish, spotted scat (Scatophagus argus) exposed to diazinon. Bull Environ Contam Toxicol 94:164–170

    CAS  Google Scholar 

  • Hassani S, Maqbool F, Salek-Maghsoudi A, Rahmani S, Shadboorestan A, Nili-Ahmadabadi A, Amini M, Norouzi P, Abdollahi M (2018) Alteration of hepatocellular antioxidant gene expression pattern and biomarkers of oxidative damage in diazinon-induced acute toxicity in Wistar rat: a time-course mechanistic study. EXCLI J 17:57

    Google Scholar 

  • Hazelette, JR.. 1984. Dietary hypercholesteremia and susceptibility to the pesticide diazinon.

  • Hedayati A, Niazie EHN (2015) Hematological changes of silver carp (hypophthalmichthys molitrix) in response to Diazinon pesticide. J Environ Health Sci Eng 13:52

    Google Scholar 

  • Hooijmans CR, Rovers MM, DE Vries RB, Leenaars M, Ritskes-Hoitinga M, Langendam MW (2014) SYRCLE’s risk of bias tool for animal studies. BMC Med Res Methodol 14:43

    Google Scholar 

  • Husain K, Ansari R (1988) Influence of cholinergic and adrenergic blocking drugs on hyperglycemia and brain glycogenolysis in diazinon-treated animals. Can J Physiol Pharmacol 66:1144–1147

    CAS  Google Scholar 

  • Ivanović SR, Borozan N, Janković R, Ćupić-Miladinović D, Savić M, Ćupić V, Borozan S (2020) Functional and histological changes of the pancreas and liver in the rats after acute and subacute administration of diazinon. Vojnosanit Pregl:12–12

  • Joint F & Organization WH (1994). Pesticide residues in food: 1993, toxicology evaluations, Joint Meeting of the FAO Panel of Experts on Pesticide Residues in Food and the Environment and the WHO Expert Group on Pesticide Residues, Geneva, 20-29 September 1993. Part 2., Toxicology. World Health Organization.

  • Karimani A, Heidarpour M, Moghaddam Jafari, A. (2019) Protective effects of glycyrrhizin on sub-chronic diazinon-induced biochemical, hematological alterations and oxidative stress indices in male Wistar rats. Drug Chem Toxicol 42:300–308

    CAS  Google Scholar 

  • Katuli KK, Amiri BM, Massarsky A, Yelghi S (2014) Impact of a short-term diazinon exposure on the osmoregulation potentiality of Caspian roach (Rutilus rutilus) fingerlings. Chemosphere 108:396–404

    CAS  Google Scholar 

  • Khaksar MR, Rahimifard M, Baeeri M, Maqbool F, Navaei-Nigjeh M, Hassani S, Moeini-Nodeh S, Kebriaeezadeh A, Abdollahi M (2017) Protective effects of cerium oxide and yttrium oxide nanoparticles on reduction of oxidative stress induced by sub-acute exposure to diazinon in the rat pancreas. J Trace Elem Med Biol 41:79–90

    CAS  Google Scholar 

  • Khazaie S, Jafari M, Heydari J, Asgari A, Tahmasebi K, Salehi M, Abedini MS (2019) Modulatory effects of vitamin C on biochemical and oxidative changes induced by acute exposure to diazinon in rat various tissues: prophylactic and therapeutic roles. J Anim Physiol Anim Nutr 103:1619–1628

    CAS  Google Scholar 

  • Liu J, Zhao H, Wang Y, Shao Y, Li J, Xing M (2018) Alterations of antioxidant indexes and inflammatory cytokine expression aggravated hepatocellular apoptosis through mitochondrial and death receptor-dependent pathways in Gallus gallus exposed to arsenic and copper. Environ Sci Pollut Res 25:15462–15473

    CAS  Google Scholar 

  • Matin M, Husain K (1987a) Cerebral glucose and glycogen metabolism in diazinon-treated animals. J Biochem Toxicol 2:265–270

    CAS  Google Scholar 

  • Matin M, Husain K (1987b) Changes in cerebral glycogenolysis and related enzymes in diazinon treated hyperglycaemic animals. J Appl Toxicol 7:131–134

    CAS  Google Scholar 

  • Matin M, Khan S, Hussain K, Sattar S (1989) Effect of adrenalectomy on diazinon-induced changes in carbohydrate metabolism. Arch Toxicol 63:376–380

    CAS  Google Scholar 

  • Matin M, Sattar S, Husain K (1990a) The role of adrenals in diazinon-induced changes in carbohydrate metabolism in rats. Arhiv za higijenu rada i toksikologiju 41:347–355

    CAS  Google Scholar 

  • Matin MA, Husain K, Khan SN (1990b) Modification of diazinon-induced changes in carbohydrate metabolism by adrenalectomy in rats. Biochem Pharmacol 39:1781–1786

    CAS  Google Scholar 

  • Nili-Ahmadabadi A, Akbari Z, Ahmadimoghaddam D, Larki-Harchegani A (2019) The role of ghrelin and tumor necrosis factor alpha in diazinon-induced dyslipidemia: insights into energy balance regulation. Pestic Biochem Physiol 157:138–142

    CAS  Google Scholar 

  • Pakzad M, Fouladdel S, Nili-Ahmadabadi A, Pourkhalili N, Baeeri M, Azizi E, Sabzevari O, Ostad SN, Abdollahi M (2013) Sublethal exposures of diazinon alters glucose homostasis in Wistar rats: biochemical and molecular evidences of oxidative stress in adipose tissues. Pestic Biochem Physiol 105:57–61

    CAS  Google Scholar 

  • Pourgholam R, Soltani M, Hassan M, Ghoroghi A, Nahavandi R, Pourgholam H (2006) Determination of diazinon LC50 in grass carp (Cetenopharyngodon idella) and the effect of sublethal concentration of toxin on some hematological and biochemical indices. Iran J Fish Sci 5:67–82

    Google Scholar 

  • Pradhan SC, Patra AK (2017) Study of action of sublethal concentrations of diazinon on blood indices of male and female Anabas testudineus. Der Pharmacia Sin 8(3):21–28

    CAS  Google Scholar 

  • Rafieepour A, Hajirezaee S, Rahimi R (2020) Moderating effects of dietary oregano extract (Origanum vulgare) on the toxicity induced by organophosphate pesticide, diazinon in rainbow trout, Oncorhynchus mykiss: metabolic hormones, histology and growth parameters. Turk J Fish Aquat Sci 20:207–219

    Google Scholar 

  • Rahimi R, Abdollahi M (2007) A review on the mechanisms involved in hyperglycemia induced by organophosphorus pesticides. Pestic Biochem Physiol 88:115–121

    CAS  Google Scholar 

  • Ramirez-Vargas MA, Flores-Alfaro E, Uriostegui-Acosta M, Alvarez-Fitz P, Parra-Rojas I, Moreno-Godinez ME (2018) Effects of exposure to malathion on blood glucose concentration: a meta-analysis. Environ Sci Pollut Res 25:3233–3242

    CAS  Google Scholar 

  • Rodríguez-Lara A, Mesa MD, Aragón-Vela J, Casuso RA, Casals Vázquez C, Zúñiga JM, Huertas JR (2019) Acute/subacute and sub-chronic oral toxicity of a hidroxytyrosol-rich virgin olive oil extract. Nutrients 11:2133

    Google Scholar 

  • Ruan H, Lodish HF (2003) Insulin resistance in adipose tissue: direct and indirect effects of tumor necrosis factor-α. Cytokine Growth Factor Rev 14:447–455

    CAS  Google Scholar 

  • Salek-Maghsoudi A, Hassani S, Momtaz S, Shadboorestan A, Ganjali MR, Ghahremani MH, Hosseini R, Norouzi P, Abdollahi M (2019) Biochemical and molecular evidence on the role of vaspin in early detection of the insulin resistance in a rat model of high-fat diet and use of diazinon. Toxicology 411:1–14

    CAS  Google Scholar 

  • Sastry K, Sharma K (1981) Diazinon-induced hematological changes in Ophiocephalus (Channa) punctatus. Ecotoxicol Environ Saf 5:171–176

    CAS  Google Scholar 

  • Scells H, Zuccon G, Koopman B, Deacon A, Azzopardi L & Geva S (2017) Integrating the framing of clinical questions via PICO into the retrieval of medical literature for systematic reviews. Proceedings of the 2017 ACM on Conference on Information and Knowledge Management. 2291-2294.

  • Seifert J (2001) Toxicologic significance of the hyperglycemia caused by organophosphorous insecticides. Bull Environ Contam Toxicol 67:463–469

    CAS  Google Scholar 

  • Shamoushaki MMN, Soltani M, Kamali A, Imanpoor M, Sharifpour I, Khara H (2012) Effects of organophosphate, diazinon on some haematological and biochemical changes in Rutilus frisii kutum (Kamensky, 1901) male brood stocks. Iran J Fish Sci 11:105–117

    Google Scholar 

  • Shokrzadeh M, Ahangar N, Abdollahi M, Shadboorestan A, Omidi M, Payam SH (2013) Potential chemoprotective effects of selenium on diazinon-induced DNA damage in rat peripheral blood lymphocyte. Hum Exp Toxicol 32:759–765

    CAS  Google Scholar 

  • Sidhu GK, Singh S, Kumar V, Dhanjal DS, Datta S, Singh J (2019) Toxicity, monitoring and biodegradation of organophosphate pesticides: a review. Crit Rev Environ Sci Technol 49:1135–1187

    CAS  Google Scholar 

  • Teimouri F, Amirkabirian N, Esmaily H, Mohammadirad A, Aliahmadi A, Abdollahi M (2006) Alteration of hepatic cells glucose metabolism as a non-cholinergic detoxication mechanism in counteracting diazinon-induced oxidative stress. Hum Exp Toxicol 25:697–703

    CAS  Google Scholar 

  • Ueyama J, Kamijima M, Asai K, Mochizuki A, Wang D, Kondo T, Suzuki T, Takagi K, Takagi K, Kanazawa H (2008) Effect of the organophosphorus pesticide diazinon on glucose tolerance in type 2 diabetic rats. Toxicol Lett 182:42–47

    CAS  Google Scholar 

  • Wang W, Luo S-M, Ma J-Y, Shen W, Yin S (2018) Cytotoxicity and DNA damage caused from diazinon exposure by inhibiting the PI3K-AKT pathway in porcine ovarian granulosa cells. J Agric Food Chem 67:19–31

    Google Scholar 

  • Yousefizadeh S, Farkhondeh T, Samarghandian S (2019) Age-related diazinon toxicity impact on blood glucose, lipid profile and selected biochemical indices in male rats. Current aging science 12:49–54

    CAS  Google Scholar 

  • Zeinali M, Meybodi NT, Rezaee SA, Rafatpanah H, Hosseinzadeh H (2018) Protective effects of chrysin on sub-acute diazinon-induced biochemical, hematological, histopathological alterations, and genotoxicity indices in male BALB/c mice. Drug Chem Toxicol 41:270–280

    CAS  Google Scholar 

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Availability of data and materials

The data that support the findings of this study are available from the corresponding author (SS) upon reasonable request.

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Authors and Affiliations

  1. Medical Toxicology and Drug Abuse Research Center (MTDRC), Birjand University of Medical Sciences (BUMS), Birjand, Iran

    Tahereh Farkhondeh, Mahmood Sadeghi & Kobra Naseri

  2. Faculty of Pharmacy, Birjand University of Medical Sciences, Birjand, Iran

    Tahereh Farkhondeh & Kobra Naseri

  3. Department of Molecular Pharmacology, Albert Einstein College of Medicine, Forchheimer 209, 1300 Morris Park Avenue, Bronx, NY, USA

    Michael Aschner

  4. Arizona Poison & Drug Information Center, the University of Arizona, college of pharmacy and university of Arizona, Tucson, Arizona, USA

    Omid Mehrpour

  5. Scientific unlimited horizon, Tucson, Arizona, USA

    Omid Mehrpour

  6. Cardiovascular Diseases Research Center, Birjand University of Medical Sciences, Birjand, Iran

    Alireza Amirabadizadeh

  7. Student Research Committee, Birjand University of Medical Sciences, Birjand, Iran

    Babak Roshanravan

  8. Student Research Committee, BSc Student in Medical LaboratoryScience, Birjand University of Medical Sciences, Birjand, Iran

    Hamed Aramjoo

  9. Noncommunicable Diseases Research Center, Neyshabur University of Medical Sciences, Neyshabur, Iran

    Saeed Samarghandian

Authors
  1. Tahereh Farkhondeh
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  2. Michael Aschner
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  3. Mahmood Sadeghi
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  4. Omid Mehrpour
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  5. Kobra Naseri
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  6. Alireza Amirabadizadeh
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  8. Hamed Aramjoo
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  9. Saeed Samarghandian
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Contributions

Substantial contributions to the conception or design of the work: Saeed Samarghandian and Tahereh Farkhondeh. The acquisition and analysis of data for the work: Tahereh Farkhondeh, Alireza Amirabadizadeh, Babak Roshanravan, Hamed Aramjoo, and Mahmood Sadeghi. Interpretation of data for the work: Saeed Samarghandian, Michael Aschner, and Omid Mehrpour. Drafting the work: Tahereh Farkhondeh, Mahmood Sadeghi, and Kobra Naseri. Revising manuscript critically for important intellectual content: Micheal Aschenr, Omid Mehrpour, and Saeed Samarghandian. Final approval of the version to be published: Tahereh Farkhondeh, Micheal Aschenr, Mahmood Sadeghi, Kobra Naseri, Omid Mehrpour, Babak Roshanravan, Hamed Aramjoo, and Saeed Samarghandian.

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Correspondence to Saeed Samarghandian.

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Farkhondeh, T., Aschner, M., Sadeghi, M. et al. The effect of diazinon on blood glucose homeostasis: a systematic and meta-analysis study. Environ Sci Pollut Res 28, 4007–4018 (2021). https://doi.org/10.1007/s11356-020-11364-0

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