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LINC01133: an emerging tumor-associated long non-coding RNA in tumor and osteosarcoma

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Abstract

Emerging evidence suggested that long non-coding RNAs (lncRNAs) play pivotal roles in tumorigenesis. LINC01133 is a newly identified lncRNA first discovered as an oncogene in lung squamous cell carcinoma. Subsequent studies further demonstrated this lncRNA was deregulated in a wide spectrum of tumors, including colorectal, gastric, lung, and pancreatic ductal adenocarcinoma as well as osteosarcoma and hepatocellular carcinoma. Intriguingly, this lncRNA exerted oncogenic or tumor-suppressive action in a tissue-dependent manner. This review sought to summarize our current understanding concerning the deregulation of LINC01133 in human tumors in relation to its molecular mechanisms and cellular functions. The clinical utilization of LINC01133 as a potential prognostic biomarker and a treatment target is also discussed.

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Authors and Affiliations

  1. Department of Orthopaedic, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China

    Zheng Li, Xin Chen & Shugang Li

  2. Department of Orthopedics, The Affiliated Hospital of Qingdao University, Qingdao, 266003, China

    Derong Xu

  3. Department of Anaesthesia and Intensive Care and Peter Hung Pain Research Institute, The University of Hong Kong, Pok Fu Lam, Hong Kong

    Matthew T. V. Chan & William K. K. Wu

  4. State Laboratory of Digestive Diseases, Centre for Gut Microbiota Research, Institute of Digestive Diseases and LKS Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong, Hong Kong

    William K. K. Wu

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  1. Zheng Li
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  2. Derong Xu
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  3. Xin Chen
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  4. Shugang Li
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  5. Matthew T. V. Chan
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  6. William K. K. Wu
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Contributions

Zheng Li, Derong Xu, Shugang Li, M T.V. Chan, and Xin Chen have all contributed to design and write manuscript.

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Correspondence to Shugang Li.

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The authors declare that they have no conflict of interest.

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Responsible editor: Lotfi Aleya

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Zheng Li, Derong Xu, and Xin Chen are co-first authors.

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Li, Z., Xu, D., Chen, X. et al. LINC01133: an emerging tumor-associated long non-coding RNA in tumor and osteosarcoma. Environ Sci Pollut Res 27, 32467–32473 (2020). https://doi.org/10.1007/s11356-020-09631-1

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  • DOI: https://doi.org/10.1007/s11356-020-09631-1

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