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Effects of vitamin A and vitamin E on attenuation of amphotericin B-induced side effects on kidney and liver of male Wistar rats

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Abstract

Despite the fact that amphotericin B (AmB) is currently considered as the first choice for treatment of visceral leishmaniasis, it is associated with some side effects. This study was designed to investigate the protective effects of vitamins A and E against amphotericin B-induced adverse effects in the kidney and liver of rat. Thirty male Wistar rats aged 7–8 weeks and weighing around 200 g were randomly divided into five groups, each one containing six rats. The first to fifth groups received olive oil as the control groups, AmB, AmB + vitamin A, AmB + vitamin E, and AmB + vitamins A + E, respectively. Rats received vitamins by gavage (vitamin A, 1000 IU/kg and vitamin E, 100 IU/kg) and amphotericin B by injections (5.5 mg/kg body weight). The treatment was constantly continued for 5 days and days 7 and 21. At the end of the study, serum level of TAC, TOS, MDA, liver enzyme activity (ALT, AST, ALP, LDH), renal factors (urea, uric acid, and creatinine), lipid profile as well as histopathological changes of the liver and kidney were investigated. AmB significantly increased serum level of creatinine, urea, uric acid, ALP, TOS, MDA, and kidney and renal tissue damage (p < 0.05). Supplementation AmB with vitamins A and E alone or combination improved oxidative stress status, liver and renal tissue structure, and functional parameters and serum lipid profile. This study highlighted the effects of vitamin A and vitamin E on attenuation of amphotericin B-induced side effects on the kidney and liver of male Wistar rats. Combination of the two vitamins is more effective than either alone improving the oxidative stress status, serum lipid profile, or liver and renal tissue structure and functional parameters.

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Funding

This study was funded by Vice-chancellor for Research and Technology, Hamadan University of Medical Sciences (Grant No. 9710045894).

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Authors and Affiliations

  1. Department of Medical Entomology, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran

    Aref Salehzadeh

  2. Medical student of Hamadan University of Medical Sciences, Hamadan, Iran

    Alireza Salehzadeh

  3. Department of Medical Parasitology and Mycology, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran

    Amir-Hossein Maghsood

  4. Department of Medical Biochemistry, School of Medicine, Hamadan University of Medical Sciences, Hamadan, 65178, Iran

    Shirin Heidarisasan & Roghayeh Abbasalipourkabir

  5. Neurophysiology Research Center, Hamadan University of Medical Sciences, Hamadan, Iran

    Masoumeh Taheri-Azandaryan

  6. Department of Medicinal Chemistry, School of Pharmacy, Hamadan University of Medical Sciences, Hamadan, Iran

    Abolfazl Ghafourikhosroshahi

Authors
  1. Aref Salehzadeh
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  2. Alireza Salehzadeh
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  3. Amir-Hossein Maghsood
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  4. Shirin Heidarisasan
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  6. Abolfazl Ghafourikhosroshahi
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  7. Roghayeh Abbasalipourkabir
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Correspondence to Roghayeh Abbasalipourkabir.

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The authors declare that they have no competing interest.

Ethics approval and consent to participate

All techniques for the treatment of animals were approved by the Research Committee of Hamadan University of Medical Sciences (UMSHA), Iran, and the research was conducted according to the guidelines for the care and use of laboratory animals of UMSHA (Res:IR.UMSHA.REC.1397.646).

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Salehzadeh, A., Salehzadeh, A., Maghsood, AH. et al. Effects of vitamin A and vitamin E on attenuation of amphotericin B-induced side effects on kidney and liver of male Wistar rats. Environ Sci Pollut Res 27, 32594–32602 (2020). https://doi.org/10.1007/s11356-020-09547-w

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