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Therapeutic role of garlic and vitamins C and E against toxicity induced by lead on various organs

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Abstract

Due to industrial and urban sewage, the metal contaminations in aquatic and terrestrial environments are increasing day by day, especially in developing countries. Despite the study of several years, we are inert far away from an actual medication for prolonged toxicity of heavy metals such as mercury, lead, cadmium etc. Lead is one of the most common heavy metals that possess toxicological effects on numerous tissues of animals as well as humans. Several toxic effects of lead on reproductive organs, renal system, central nervous system, liver, lungs, blood parameters, and bones have been reported. On the other hand, several reports depicted that garlic is operative in declining the absorption of lead in bones as well as soft tissues. A combination of vitamin C and vitamin E enhances the biological recovery induced by lead and mobilize the heavy metal such as lead from intra-cellular positions. This review provides therapeutic approaches such as vitamin C, vitamin E, and extract of garlic to treat the detrimental effects caused after the exposure of lead. These therapeutic strategies are beneficial for both the prevention and alleviation of lead noxiousness.

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  1. Applied Entomolgy and Medical Toxicology Laboratory, Department of Zoology, Government College University Lahore, Lahore, 54000, Pakistan

    Shumaila Mumtaz, Shaukat Ali, Hafiz Muhammad Tahir & Samiara Mumtaz

  2. Microbial Biotechnology and Medical Toxicology Laboratory, Department of Zoology, University of Azad Jammu and Kashmir, Muzaffarabad, Pakistan

    Rida Khan & Saiqa Andleeb

  3. Department of Zoology, University of the Punjab, Lahore, Pakistan

    Hafiz Abdullah Shakir

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  1. Shumaila Mumtaz
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  2. Shaukat Ali
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  3. Rida Khan
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Mumtaz, S., Ali, S., Khan, R. et al. Therapeutic role of garlic and vitamins C and E against toxicity induced by lead on various organs. Environ Sci Pollut Res 27, 8953–8964 (2020). https://doi.org/10.1007/s11356-020-07654-2

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