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Movento effects on learning and hippocampal brain-derived neurotrophic factor protein of adult male rats

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Abstract

Spirotetramat is a toxic commercially known as Movento used to control pistachio psylla pests. In the present study, the effects of Movento on passive avoidance learning of rats and their ability to explore the novel object in the novel object recognition test were investigated. The changes in the concentration of hippocampal brain-derived neurotrophic factor (BDNF) proteins were evaluated, too. Male Wistar rats were gavaged at different dosages of the Movento (50, 100, 250, 500, 1000, 1250, and 1500 mg/kg) or saline for 7 days (administered every 2 days). We showed that Movento caused 50 and 100% mortality at the dose of 1250 and 1500 mg/kg, respectively. At the dose of 1000 mg/kg, Movento significantly decreased locomotor activity (P < 0.05). These rats also displayed a significant decrease in the number of training trials in the shuttle box and the ability to recognize a novel object compared with the control group (P < 0.01). The BDNF protein level of hippocampus also showed a significant decrease in the Movento (1000 mg/kg) compared with the control group (P < 0.01) while the number of pancellular necrosis pyramidal CA1 cells increased significantly in the Movento group (P < 0.001). We concluded that exposure to Movento can decline sensory, motor, and learning in rats.

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Acknowledgments

This study is extracted from the dissertation of Mr. Iman Zangiabadi as a submitted proposal under ethical code number of IR.KMU.REC.1397.255. The authors also appreciate collaboration of KNRC.

Funding

This paper received support from the Kerman Neuroscience Research Center (EC/KNRC/95-43).

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Authors and Affiliations

  1. Department of Anatomy, School of Medicine, Kerman University of Medical Sciences, Kerman, Iran

    Iman Zangiabadi & Ali Shamsara

  2. Kerman Neuroscience Research Center, Institute of Neuropharmachology, Kerman University of Medical Sciences, 76198-13159, Kerman, Iran

    Mohammad Reza Afarinesh & Seyed Hasan Eftekhar-Vaghefi

  3. Kerman Cognitive Neuroscience Research Center, Institute of Neuropharmachology, Kerman University of Medical Sciences, Kerman, Iran

    Mohammad Reza Afarinesh

  4. Department of Anatomy, Kerman Branch, Islamic Azad University, Kerman, Iran

    Seyed Hasan Eftekhar-Vaghefi

Authors
  1. Iman Zangiabadi
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  2. Mohammad Reza Afarinesh
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  3. Ali Shamsara
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  4. Seyed Hasan Eftekhar-Vaghefi
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Correspondence to Mohammad Reza Afarinesh or Seyed Hasan Eftekhar-Vaghefi.

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Zangiabadi, I., Afarinesh, M.R., Shamsara, A. et al. Movento effects on learning and hippocampal brain-derived neurotrophic factor protein of adult male rats. Environ Sci Pollut Res 26, 36615–36622 (2019). https://doi.org/10.1007/s11356-019-06809-0

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  • DOI: https://doi.org/10.1007/s11356-019-06809-0

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