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The anti-inflammatory influence of Cinnamomum burmannii against multi-walled carbon nanotube-induced liver injury in rats

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Abstract

Carbon nanotubes (CNTs) are extensively used in nanotechnology due to their unique physico-chemical properties. CNTs were implicated in many disorders connected with human health. So, we aimed in this study to provide new insight into the role of aqueous C. burmannii in treating the possible hepatotoxic effects of multi-walled carbon nanotube (MWCNTs) exposure. A total of 32 male albino rats were divided into 4 groups: control group, cinnamon-treated group, MWCNT-treated, and cinnamon- and MWCNT-treated group. To achieve the aim of this study, evaluation of percentage change of body weight, oxidant, and antioxidant status including lipid peroxidation (LPO), nitrite, total thiols, glutathione contents (GSH), the activity of superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), and glutathione-S transferase (GST) was done. Histopathological examination and the rate of pro-inflammatory cytokines including interleukin-6 (IL-6), interleukin-1β (IL-1β), cyclooxygenase-1 (COX-1), and tumor necrotic factor-α were performed. Oral administration of aqueous C. burmannii to those MWCNT-treated rats resulted in a significant reduction in LPO and total thiol contents with a significant elevation in the activities of SOD, CAT, and GPX, while GSH content and GST activity were not significantly affected. We observed a significant downregulation in the rate of previous pro-inflammatory cytokines. All this improvement in these examined markers resulted in a significant modulation in the hepatic histopathological lesions caused by MWCNTs. Aqueous C. burmannii extract exhibited a potential defensive effect on the hepatic injury triggered by MWCNTs through upgrading the antioxidant system and downregulating the rate of pro-inflammatory cytokines.

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Authors and Affiliations

  1. Forensic Medicine and Toxicology Department, Faculty of Veterinary Medicine, Beni-Suef University, Beni-Suef, Egypt

    Khaled Abbas HelmyAbdou & Doaa Ramadan I. Abdel-Gawad

  2. Zoology Department, Faculty of Science, Beni-Suef University, Beni-Suef, Egypt

    Rasha Rashad Ahmed

  3. Biochemistry Department, Faculty of Veterinary Medicine, Cairo University, Giza, 12211, Egypt

    Marwa A. Ibrahim

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  1. Khaled Abbas HelmyAbdou
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  2. Rasha Rashad Ahmed
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  3. Marwa A. Ibrahim
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  4. Doaa Ramadan I. Abdel-Gawad
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Correspondence to Marwa A. Ibrahim.

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HelmyAbdou, K.A., Ahmed, R.R., Ibrahim, M.A. et al. The anti-inflammatory influence of Cinnamomum burmannii against multi-walled carbon nanotube-induced liver injury in rats. Environ Sci Pollut Res 26, 36063–36072 (2019). https://doi.org/10.1007/s11356-019-06707-5

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