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Hepatic ameliorative role of vitamin B17 against Ehrlich ascites carcinoma–induced liver toxicity

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11 April 2024 Editor’s Note: Readers are alerted that the concerns have been raised with this article. Editorial action will be taken as appropriate once this matter is resolved and all parties have been given an opportunity to respond in full.

Abstract

Vitamin B17 (VB17), also known as amygdalin and laetrile, is a type of carbohydrate occurring naturally in many plants, such as apricot kernels which have obtained a great interest in cancer therapy. This study aimed to investigate the hepatic protective potential of VB17 against Ehrlich ascites carcinoma (EAC)–bearing mice-induced liver injury, DNA damage, apoptotic P53, and PCNA alterations. A total of 100 female mice were divided into 5 groups (1st group, control group; 2nd group, VB17 group; 3rd group, EAC group; 4th group, pre-treated EAC with VB17; 5th group, co-treated EAC with VB17). Results showed that the presence of VB17 in pre-treated and co-treated groups lead to decreased DNA damage, microsomal protein, NADPH cytochrome c reductase, alpha-fetoprotein (AFP), AST, ALT, and ALP while showed increased cytochrome b5, cytochrome P450 amidopyrine N-demethylase, and aniline 4-hydroxylase compared with the EAC group. Many histopathological changes were observed in liver sections in EAC as moderate fibrosis and marked diffuse necrosis of hepatic tissue, marked inflammatory cells, and congested blood sinusoids. On the other hand, there was a moderate degree of improvement in hepatocytes in liver sections in pre-treated VB17+EAC, while a mild degree of improvement in hepatocytes, moderate cellular infiltrations, and moderate cytoplasmic vacuolization of hepatocytes in liver sections in co-treated EAC+VB17. In addition, there was a depletion in hepatic P53 and PCNA protein expression compared with the EAC group. It could be concluded that VB17 has a potential hepatoprotective effect against EAC cell–induced liver toxicity.

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  • 11 April 2024

    Editor’s Note: Readers are alerted that the concerns have been raised with this article. Editorial action will be taken as appropriate once this matter is resolved and all parties have been given an opportunity to respond in full.

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Authors and Affiliations

  1. Zoology Department, Faculty of Science, Tanta University, Tanta, Egypt

    Ehab Tousson, Ezar Hafez, Siham Bayomi Salem & Thulfiqar Fawwaz Mutar

  2. Histology Department, Faculty of Medicine, Kafr El Sheikh University, Kafr El Sheikh, Egypt

    Maha Mohamed Abo Gazia

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  1. Ehab Tousson
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  2. Ezar Hafez
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  3. Maha Mohamed Abo Gazia
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Correspondence to Thulfiqar Fawwaz Mutar.

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All experiments were conducted according to the guidelines for animal studies published by the Ethical Committee of Faculty of Science, Tanta University, with the approval of the Institutional Animal Care and Use Committee (IACUC-SCI-TU-0046).

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Tousson, E., Hafez, E., Abo Gazia, M.M. et al. Hepatic ameliorative role of vitamin B17 against Ehrlich ascites carcinoma–induced liver toxicity. Environ Sci Pollut Res 27, 9236–9246 (2020). https://doi.org/10.1007/s11356-019-06528-6

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