Exposure to bisphenol A and diabetes risk in Mexican women

Murphy, Luke; Mérida-Ortega, Ángel; Cebrián, Mariano E.; Hernández-Garciadiego, Lucia; Gómez-Ruiz, Humberto; Gamboa-Loira, Brenda; López-Carrillo, Lizbeth

doi:10.1007/s11356-019-05731-9

Research Article
Published: 09 July 2019

Exposure to bisphenol A and diabetes risk in Mexican women

Luke Murphy^1,2,
Ángel Mérida-Ortega¹,
Mariano E. Cebrián³,
Lucia Hernández-Garciadiego⁴,
Humberto Gómez-Ruiz⁴,
Brenda Gamboa-Loira¹ &
Lizbeth López-Carrillo ORCID: orcid.org/0000-0002-3245-8337^1,5

Environmental Science and Pollution Research volume 26, pages 26332–26338 (2019)Cite this article

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Abstract

Bisphenol A (BPA) is an endocrine-disrupting chemical widely used in the production of polycarbonate plastics and epoxy resins, which has been previously linked to diabetes among non-Hispanic populations. As part of a case control study for breast cancer, only controls with BPA information were included in this report. The final sample size comprises 70 self-reported diabetics and 334 non-diabetics. Urinary free bisphenol A (BPA-F) (μg/L) was determined by solid-phase extraction and HPLC/FLD analysis. Logistic regression models were used to evaluate the association between BPA-F and self-reported diabetes. After adjusting by age, urinary BPA-F (4.06–224.53 μg/g creatinine) was associated with diabetes exposure (OR = 1.85; 95% CI 1.04, 3.28) compared with women in the reference category (0.67–4.05 μg/g creatinine). BPA may be an environmental cofactor of diabetes. More studies are needed to confirm this result, especially in Hispanic populations.

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Acknowledgements

The authors thank Rosa María García Hernández and Guadalupe Lina García Hernández for their assistance in BPA extraction and Belen Barajas L. for literature search.

Funding

This study was partially supported by CONACYT Fondo Sectorial de Investigación en Salud y Seguridad Social 2005-2-14373, 2009-1-111384, 2010-1-140962, PDCPN 2013-01-215464 and 272632, and the Advanced Study Grant and Gabelli Presidential Scholars Programs of Boston College.

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Authors and Affiliations

Center for Research in Population Health, National Institute of Public Health, Cuernavaca, Morelos, Mexico
Luke Murphy, Ángel Mérida-Ortega, Brenda Gamboa-Loira & Lizbeth López-Carrillo
Department of Biology, Boston College, Chestnut Hill, MA, USA
Luke Murphy
Department of Toxicology, CINVESTAV, Mexico City, Mexico
Mariano E. Cebrián
Department of Analytical Chemistry, National Autonomous University of Mexico, Mexico City, Mexico
Lucia Hernández-Garciadiego & Humberto Gómez-Ruiz
Instituto Nacional de Salud Pública, Universidad 655, col. Santa María Ahuacatitlán, C.P 62100, Cuernavaca, Morelos, Mexico
Lizbeth López-Carrillo

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Luke Murphy
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Ángel Mérida-Ortega
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Mariano E. Cebrián
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Lucia Hernández-Garciadiego
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Humberto Gómez-Ruiz
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Brenda Gamboa-Loira
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Lizbeth López-Carrillo
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Correspondence to Lizbeth López-Carrillo.

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The study was approved by the ethics committee of the National Institute of Public Health of Mexico.

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Responsible editor: Philippe Garrigues

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Murphy, L., Mérida-Ortega, Á., Cebrián, M.E. et al. Exposure to bisphenol A and diabetes risk in Mexican women. Environ Sci Pollut Res 26, 26332–26338 (2019). https://doi.org/10.1007/s11356-019-05731-9

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Received: 10 January 2019
Accepted: 10 June 2019
Published: 09 July 2019
Issue Date: 01 September 2019
DOI: https://doi.org/10.1007/s11356-019-05731-9

Keywords

Diabetes
Bisphenol a
BPA
Endocrine-disrupting chemical
Mexico
Women