Bisphenol A (BPA) is an endocrine-disrupting chemical widely used in the production of polycarbonate plastics and epoxy resins, which has been previously linked to diabetes among non-Hispanic populations. As part of a case control study for breast cancer, only controls with BPA information were included in this report. The final sample size comprises 70 self-reported diabetics and 334 non-diabetics. Urinary free bisphenol A (BPA-F) (μg/L) was determined by solid-phase extraction and HPLC/FLD analysis. Logistic regression models were used to evaluate the association between BPA-F and self-reported diabetes. After adjusting by age, urinary BPA-F (4.06–224.53 μg/g creatinine) was associated with diabetes exposure (OR = 1.85; 95% CI 1.04, 3.28) compared with women in the reference category (0.67–4.05 μg/g creatinine). BPA may be an environmental cofactor of diabetes. More studies are needed to confirm this result, especially in Hispanic populations.
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The authors thank Rosa María García Hernández and Guadalupe Lina García Hernández for their assistance in BPA extraction and Belen Barajas L. for literature search.
This study was partially supported by CONACYT Fondo Sectorial de Investigación en Salud y Seguridad Social 2005-2-14373, 2009-1-111384, 2010-1-140962, PDCPN 2013-01-215464 and 272632, and the Advanced Study Grant and Gabelli Presidential Scholars Programs of Boston College.
The study was approved by the ethics committee of the National Institute of Public Health of Mexico.
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Murphy, L., Mérida-Ortega, Á., Cebrián, M.E. et al. Exposure to bisphenol A and diabetes risk in Mexican women. Environ Sci Pollut Res 26, 26332–26338 (2019). https://doi.org/10.1007/s11356-019-05731-9
- Bisphenol a
- Endocrine-disrupting chemical