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Canned food intake and urinary bisphenol a concentrations: a randomized crossover intervention study

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Bisphenol A (BPA) is an endocrine disruptor. To evaluate the effect of canned food consumption on internal BPA dose, urinary BPA concentrations were measured before and after intake of canned foods. This study applied a randomized crossover design, recruited 20 healthy volunteers, and divided them into two groups. One group consumed canned food; the other group consumed fresh food. After a 1-day washout, the dietary interventions were reversed. In each period, urine samples were collected immediately before meals and then 2 h, 4 h, and 6 h after meals. A mixed-effects model was used to assess BPA changes over time. Our results showed urinary BPA concentrations increased after consumption of canned food. Specifically, urinary BPA concentrations significantly differed between consumption of canned food and fresh food at 2 h, 4 h, and 6 h after intake (p values of 0.001, < 0.001, and < 0.001, respectively). Mean BPA concentrations at 2 h, 4 h, and 6 h after meals were 152%, 206%, and 79% higher, respectively, than mean BPA concentrations before meals. Urine concentration profiles of canned food intake showed that peaks were at 4 h, the increase diminished at 6 h, and returned to baseline levels at 24 h after intake. Therefore, dietary intervention and a 1-day washout period are effective for limiting internal BPA burden. This study provides convincing evidence of a human exposure route to BPA and a basis for designing interventions to mitigate exposure.

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This study was supported by grants from the National Science Council of Taiwan (NSC 102-2632-B-037-001-MY3) and from Kaohsiung Medical University (“Aim for the Top Universities Grant” KMU-TP103A16 and KMU-TP104A01).

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TNW, CYP, and EMT involved in the conception and design of the current analysis. THK, TCL, SSL, and CCC collected or analyzed data. CYP and TNW analyzed the data and drafted the manuscript. All authors participated in the interpretation of results and revision of the manuscript. All authors approved the final version of the manuscript.

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Correspondence to Eing-Mei Tsai or Tsu-Nai Wang.

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The authors declare that they have no conflict of interest.


No funding agencies had a role in the design of this study, in the collection, analysis or interpretation of data, or in the writing of this report.

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Responsible editor: Philippe Garrigues

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Peng, CY., Tsai, EM., Kao, TH. et al. Canned food intake and urinary bisphenol a concentrations: a randomized crossover intervention study. Environ Sci Pollut Res 26, 27999–28009 (2019).

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