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Canned food intake and urinary bisphenol a concentrations: a randomized crossover intervention study

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Abstract

Bisphenol A (BPA) is an endocrine disruptor. To evaluate the effect of canned food consumption on internal BPA dose, urinary BPA concentrations were measured before and after intake of canned foods. This study applied a randomized crossover design, recruited 20 healthy volunteers, and divided them into two groups. One group consumed canned food; the other group consumed fresh food. After a 1-day washout, the dietary interventions were reversed. In each period, urine samples were collected immediately before meals and then 2 h, 4 h, and 6 h after meals. A mixed-effects model was used to assess BPA changes over time. Our results showed urinary BPA concentrations increased after consumption of canned food. Specifically, urinary BPA concentrations significantly differed between consumption of canned food and fresh food at 2 h, 4 h, and 6 h after intake (p values of 0.001, < 0.001, and < 0.001, respectively). Mean BPA concentrations at 2 h, 4 h, and 6 h after meals were 152%, 206%, and 79% higher, respectively, than mean BPA concentrations before meals. Urine concentration profiles of canned food intake showed that peaks were at 4 h, the increase diminished at 6 h, and returned to baseline levels at 24 h after intake. Therefore, dietary intervention and a 1-day washout period are effective for limiting internal BPA burden. This study provides convincing evidence of a human exposure route to BPA and a basis for designing interventions to mitigate exposure.

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References

  • Andra SS, Austin C, Yang J, Patel D, Arora M (2016) Recent advances in simultaneous analysis of bisphenol A and its conjugates in human matrices: exposure biomarker perspectives. Sci Total Environ 572:770–781

    Article  CAS  Google Scholar 

  • Ayyanan A, Laribi O, Schuepbach-Mallepell S, Schrick C, Gutierrez M, Tanos T, Lefebvre G, Rougemont J, Yalcin-Ozuysal O, Brisken C (2011) Perinatal exposure to bisphenol a increases adult mammary gland progesterone response and cell number. Mol Endocrinol 25(11):1915–1923

  • Biedermann S, Tschudin P, Grob K (2010) Transfer of bisphenol A from thermal printer paper to the skin. Anal Bioanal Chem 398(1):571–576

    Article  CAS  Google Scholar 

  • Braun JM, Yolton K, Dietrich KN, Hornung R, Ye X, Calafat AM, Lanphear BP (2009) Prenatal bisphenol A exposure and early childhood behavior. Environ Health Perspect 117(12):1945–1952

    Article  CAS  Google Scholar 

  • Calafat A (2011) BPA biomonitoring and biomarker studies. World Health Organization, Geneva

    Google Scholar 

  • Carwile JL, Michels KB (2011) Urinary bisphenol A and obesity: NHANES 2003-2006. Environ Res 111(6):825–830

    Article  CAS  Google Scholar 

  • Carwile JL, Ye X, Zhou X, Calafat AM, Michels KB (2011) Canned soup consumption and urinary bisphenol A: a randomized crossover trial. Jama 306(20):2218–2220

    Article  CAS  Google Scholar 

  • Dairkee SH, Seok J, Champion S, Sayeed A, Mindrinos M, Xiao W, Davis RW, Goodson WH (2008) Bisphenol A induces a profile of tumor aggressiveness in high-risk cells from breast cancer patients. Cancer Res 68(7):2076–2080

    Article  CAS  Google Scholar 

  • Dekant W, Volkel W (2008) Human exposure to bisphenol A by biomonitoring: methods, results and assessment of environmental exposures. Toxicol Appl Pharmacol 228(1):114–134

    Article  CAS  Google Scholar 

  • Geens T, Aerts D, Berthot C, Bourguignon JP, Goeyens L, Lecomte P, Maghuin-Rogister G, Pironnet AM, Pussemier L, Scippo ML, Van Loco J, Covaci A (2012) A review of dietary and non-dietary exposure to bisphenol A. Food Chem Toxicol 50(10):3725–3740

  • He Y, Miao M, Herrinton LJ, Wu C, Yuan W, Zhou Z, Li D-K (2009a) Bisphenol A levels in blood and urine in a Chinese population and the personal factors affecting the levels. Environ Res 109:629–633

    Article  CAS  Google Scholar 

  • He Y, Miao M, Wu C, Yuan W, Gao E, Zhou Z, Li DK (2009b) Occupational exposure levels of bisphenol A among Chinese workers. J Occup Health 51(5):432–436

    Article  CAS  Google Scholar 

  • Health Canada (2017) Fourth report on human biomonitoring of environmental Chemicals in Canada. Publications, Health Canada, Ottawa, Ontario, Canada

  • Huang YQ, Wong CK, Zheng JS, Bouwman H, Barra R, Wahlstrom B, Neretin L, Wong MH (2012) Bisphenol A (BPA) in China: a review of sources, environmental levels, and potential human health impacts. Environ Int 42:91–99

    Article  CAS  Google Scholar 

  • Huang RP, Liu ZH, Yin H, Dang Z, Wu PX, Zhu NW, Lin Z (2018) Bisphenol a concentrations in human urine, human intakes across six continents, and annual trends of average intakes in adult and child populations worldwide: a thorough literature review. Sci Total Environ 626:971–981

    Article  CAS  Google Scholar 

  • Kesteloot HE, Joossens JV (1993) Relationship between dietary protein intake and serum urea, uric acid and creatinine, and 24-hour urinary creatinine excretion: the BIRNH study. J Am Coll Nutr 12(1):42–46

    Article  CAS  Google Scholar 

  • LaKind JS, Naiman DQ (2015) Temporal trends in bisphenol A exposure in the United States from 2003-2012 and factors associated with BPA exposure: spot samples and urine dilution complicate data interpretation. Environ Res 142:84–95

    Article  CAS  Google Scholar 

  • Lakind JS, Goodman M, Mattison DR (2014) Bisphenol A and indicators of obesity, glucose metabolism/type 2 diabetes and cardiovascular disease: a systematic review of epidemiologic research. Crit Rev Toxicol 44(2):121–150

    Article  CAS  Google Scholar 

  • Lorber M, Schecter A, Paepke O, Shropshire W, Christensen K, Birnbaum L (2015) Exposure assessment of adult intake of bisphenol A (BPA) with emphasis on canned food dietary exposures. Environ Int 77:55–62

    Article  CAS  Google Scholar 

  • Markey CM, Wadia PR, Rubin BS, Sonnenschein C, Soto AM (2005) Long-term effects of fetal exposure to low doses of the xenoestrogen bisphenol A in the female mouse genital tract. Biol Reprod 72(6):1344–1351

    Article  CAS  Google Scholar 

  • Morgan MK, Jones PA, Calafat AM, Ye X, Croghan CW, Chuang JC, Wilson NK, Clifton MS, Figueroa Z, Sheldon LS (2011) Assessing the quantitative relationships between preschool children's exposures to bisphenol A by route and urinary biomonitoring. Environ Sci Technol 45(12):5309–5316

    Article  CAS  Google Scholar 

  • MPRD (2015) Market Publisher Report Database. Bisphenol A (BPA): 2015 World Market Outlook and Forecast up to 2019. Merchant Research & Consulting, Ltd 2015; http://www.prweb.com/releases/2014/04/prweb11761146.htm. (Accessed 8/1/2015)

  • Noonan GO, Ackerman LK, Begley TH (2011) Concentration of bisphenol A in highly consumed canned foods on the U.S. market. J Agric Food Chem 59(13):7178–7185

    Article  CAS  Google Scholar 

  • Ranciere F, Lyons JG, Loh VH, Botton J, Galloway T, Wang T, Shaw JE, Magliano DJ (2015) Bisphenol A and the risk of cardiometabolic disorders: a systematic review with meta-analysis of the epidemiological evidence. Environ Health 14:46

  • Richter CA, Birnbaum LS, Farabollini F, Newbold RR, Rubin BS, Talsness CE, Vandenbergh JG, Walser-Kuntz DR, vom Saal FS (2007) In vivo effects of bisphenol A in laboratory rodent studies. Reprod Toxicol 24(2):199–224

  • Rochester JR (2013) Bisphenol A and human health: a review of the literature. Reprod Toxicol 42:132–155

  • Rudel RA, Gray JM, Engel CL, Rawsthorne TW, Dodson RE, Ackerman JM, Rizzo J, Nudelman JL, Brody JG (2011) Food packaging and bisphenol A and bis(2-ethyhexyl) phthalate exposure: findings from a dietary intervention. Environ Health Perspect 119(7):914–920

    Article  CAS  Google Scholar 

  • Shankar A, Teppala S (2011) Relationship between urinary bisphenol A levels and diabetes mellitus. J Clin Endocrinol Metab 96(12):3822–3826

    Article  CAS  Google Scholar 

  • Silver MK, O'Neill MS, Sowers MR, Park SK (2011) Urinary bisphenol A and type-2 diabetes in U.S. adults: data from NHANES 2003-2008. PLoS One 6(10):e26868

    Article  CAS  Google Scholar 

  • Teeguarden JG, Calafat AM, Ye X, Doerge DR, Churchwell MI, Gunawan R, Graham MK (2011) Twenty-four hour human urine and serum profiles of bisphenol a during high-dietary exposure. Toxicol Sci 123(1):48–57

  • Thayer KA, Doerge DR, Hunt D, Schurman SH, Twaddle NC, Churchwell MI, Garantziotis S, Kissling GE, Easterling MR, Bucher JR, Birnbaum LS (2015) Pharmacokinetics of bisphenol A in humans following a single oral administration. Environ Int 83:107–115

    Article  CAS  Google Scholar 

  • Tian YH, Baek JH, Lee SY, Jang CG (2010) Prenatal and postnatal exposure to bisphenol A induces anxiolytic behaviors and cognitive deficits in mice. Synapse 64(6):432–439

  • Vandenberg LN, Ehrlich S, Belcher SM, Ben-Jonathan N, Dolinoy DC, Hugo ER, Hunt PA, Newbold RR, Rubin BS, Saili KS, Soto AM, Wang H-S, vom Saal FS (2013) Low dose effects of bisphenol A. Endocr Disruptors 1(1):e26490

  • Volkel W, Colnot T, Csanady GA, Filser JG, Dekant W (2002) Metabolism and kinetics of bisphenol a in humans at low doses following oral administration. Chem Res Toxicol 15(10):1281–1287

    Article  Google Scholar 

  • Volkel W, Bittner N, Dekant W (2005) Quantitation of bisphenol A and bisphenol A glucuronide in biological samples by high performance liquid chromatography-tandem mass spectrometry. Drug Metab Dispos 33(11):1748–1757

  • Wang T, Li M, Chen B, Xu M, Xu Y, Huang Y, Lu J, Chen Y, Wang W, Li X, Liu Y, Bi Y, Lai S, Ning G (2012) Urinary bisphenol A (BPA) concentration associates with obesity and insulin resistance. J Clin Endocrinol Metab 97(2):E223–E227

    Article  CAS  Google Scholar 

  • Weiss B (2002) Sexually dimorphic nonreproductive behaviors as indicators of endocrine disruption. Environ Health Perspect 110(Suppl 3):387–391

    Article  Google Scholar 

  • Yang M, Kim SY, Lee SM, Chang SS, Kawamoto T, Jang JY, Ahn YO (2003) Biological monitoring of bisphenol A in a Korean population. Arch Environ Contam Toxicol 44(4):546–551

    Article  CAS  Google Scholar 

  • Zhang Z, Alomirah H, Cho H-S, Li Y-F, Liao C, Minh TB, Mohd MA, Nakata H, Ren N, Kannan K (2011) Urinary bisphenol A concentrations and their implications for human exposure in several Asian countries. Environ Sci Technol 45:7044–7050

    Article  CAS  Google Scholar 

Download references

Funding

This study was supported by grants from the National Science Council of Taiwan (NSC 102-2632-B-037-001-MY3) and from Kaohsiung Medical University (“Aim for the Top Universities Grant” KMU-TP103A16 and KMU-TP104A01).

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Author notes

  1. Eing-Mei Tsai and Tsu-Nai Wang contributed equally to this work.

Authors and Affiliations

  1. Department of Public Health, College of Health Science, Kaohsiung Medical University, Kaohsiung, Taiwan

    Chiung-Yu Peng, Tzu-Hsiung Kao, Tai-Cheng Lai & Tsu-Nai Wang

  2. Research Center for Environmental Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan

    Chiung-Yu Peng, Eing-Mei Tsai & Tsu-Nai Wang

  3. Center for Resources, Research and Development, Kaohsiung Medical University, Kaohsiung City, Taiwan

    Eing-Mei Tsai & Shih-Shin Liang

  4. Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan

    Eing-Mei Tsai

  5. Department of Obstetrics and Gynecology, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan

    Eing-Mei Tsai

  6. Department of Biotechnology, College of Life Science, Kaohsiung Medical University, Kaohsiung, Taiwan

    Shih-Shin Liang & Chien-Chih Chiu

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  1. Chiung-Yu Peng
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Contributions

TNW, CYP, and EMT involved in the conception and design of the current analysis. THK, TCL, SSL, and CCC collected or analyzed data. CYP and TNW analyzed the data and drafted the manuscript. All authors participated in the interpretation of results and revision of the manuscript. All authors approved the final version of the manuscript.

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Correspondence to Eing-Mei Tsai or Tsu-Nai Wang.

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The authors declare that they have no conflict of interest.

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No funding agencies had a role in the design of this study, in the collection, analysis or interpretation of data, or in the writing of this report.

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Responsible editor: Philippe Garrigues

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Peng, CY., Tsai, EM., Kao, TH. et al. Canned food intake and urinary bisphenol a concentrations: a randomized crossover intervention study. Environ Sci Pollut Res 26, 27999–28009 (2019). https://doi.org/10.1007/s11356-019-05534-y

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