Abstract
Nanotechnology is an emerging technology that deals with nanosized particles possessing crucial research roles and application. Disciplines like chemistry, biology, physics, engineering, materials science, and health sciences provide an accumulated knowledge of nanotechnology. Nonetheless, it has vast submissions precisely in biology, electronics, and medicine. Aimed at drug delivery system, nanoparticles are based on the mechanism of entrapment of the drugs or biomolecules into the interior structure of the particles; another mechanism could be that the drugs or the biomolecules can be absorbed onto the exterior surfaces of the particles. Currently, nanoparticles (NPs) are used in the delivery of drugs, proteins, genes, vaccines, polypeptides, nucleic acids, etc. In recent years, various applications of the drug delivery system via NPs have encountered an enormous position sector like pharmaceutical, medical, biological, and others. Considering the impact of NPs in drug delivery systems, this review focuses on the detailed profile of NPs, its impact on biology and medicine, and their commercialization prospects.
Similar content being viewed by others
Abbreviations
- NPs:
-
nanoparticles
- BBB:
-
blood–brain barrier
- SLN:
-
solid lipid nanoparticles
- NLC:
-
nanostructured lipid carrier
- QDs:
-
quantum dots
References
Abruzzo A, Cerchiara T, Bigucci F, Zuccheri G, Cavallari C, Saladini B, Luppi B (2019) Cromolyn-crosslinked chitosan nanoparticles for the treatment of allergic rhinitis. Eur J Pharm Sci 131:136–145. https://doi.org/10.1016/j.ejps.2019.02.015
Akbarzadeh A, Rezaei-Sadabady R, Davaran S, Joo SW, Zarghami N, Hanifehpour Y, Samiei M, Kouhi M, Nejati-Koshki K (2013) Liposome: classification, preparation, and applications. Nanoscale Res Lett 8:102. https://doi.org/10.1186/1556-276x-8-102
Alavi M, Karimi N, Safaei M (2017) Application of various types of liposomes in drug delivery systems. Advan Pharma Bull 7:3–9. https://doi.org/10.15171/apb.2017.002
Allen TM (2002) Ligand-targeted therapeutics in anticancer therapy. Nat Rev Cancer 2:750–763. https://doi.org/10.1038/nrc903
Allen LT, Tosetto M, Miller IS, O’Connor DP, Penney SC, Lynch I, Keenan AK, Pennington SR, Dawson KA, Gallagher WM (2006) Surface-induced changes in protein adsorption and implications for cellular phenotypic responses to surface interaction. Biomaterials 27:3096–3108. https://doi.org/10.1016/j.biomaterials.2006.01.019
Anand P, Nair HB, Sung B, Kunnumakkara AB, Yadav VR, Tekmal RR, Aggarwal BB (2010) Design of curcumin-loaded PLGA nanoparticles formulation with enhanced cellular uptake, and increased bioactivity in vitro and superior bioavailability in vivo. Biochem Pharmacol 79:330–338. https://doi.org/10.1016/j.bcp.2009.09.003
Arvizo RR, Miranda OR, Moyano DF, Walden CA, Giri K, Bhattacharya R, Robertson JD, Rotello VM, Reid JM, Mukherjee P (2011) Modulating pharmacokinetics, tumor uptake and biodistribution by engineered nanoparticles. PLoS One 6:e24374. https://doi.org/10.1371/journal.pone.0024374
Azocar MI, Alarcon R, Castillo A, Blamey JM, Walter M, Paez M (2019) Capping of silver nanoparticles by anti-inflammatory ligands: antibacterial activity and superoxide anion generation. J Photochem Photobiol B 193:100–108. https://doi.org/10.1016/j.jphotobiol.2019.02.005
Baetke SC, Lammers T, Kiessling F (2015) Applications of nanoparticles for diagnosis and therapy of cancer. Br J Radiol 88:20150207–20150207. https://doi.org/10.1259/bjr.20150207
Baker JR Jr (2009) Dendrimer-based nanoparticles for cancer therapy Hematology American Society of Hematology Education Program:708–719. https://doi.org/10.1182/asheducation-2009.1.708
Bakry R, Vallant RM, Najam-ul-Haq M, Rainer M, Szabo Z, Huck CW, Bonn GK (2007) Medicinal applications of fullerenes. Int J Nanomedicine 2:639–649
Baudino TA (2015) Targeted cancer therapy: the next generation of cancer treatment. Curr Drug Discov Technol 12:3–20
Bawa R, Bawa SR, Maebius SB, Flynn T, Wei C (2005) Protecting new ideas and inventions in nanomedicine with patents. Nanomedicine 1:150–158. https://doi.org/10.1016/j.nano.2005.03.009
Bertholon I, Vauthier C, Labarre D (2006) Complement activation by core-shell poly(isobutylcyanoacrylate)-polysaccharide nanoparticles: influences of surface morphology, length, and type of polysaccharide. Pharm Res 23:1313–1323. https://doi.org/10.1007/s11095-006-0069-0
Bhaskar K, Anbu J, Ravichandiran V, Venkateswarlu V, Rao YM (2009) Lipid nanoparticles for transdermal delivery of flurbiprofen: formulation, in vitro, ex vivo and in vivo studies. Lipids Health Dis 8:6. https://doi.org/10.1186/1476-511x-8-6
Bhatia S (2016) Nanoparticles types, classification, characterization, fabrication methods and drug delivery applications. In: Natural Polymer Drug Delivery Systems: Nanoparticles, Plants, and Algae. Springer International Publishing, Cham, pp 33–93. https://doi.org/10.1007/978-3-319-41129-3_2
Bhojani MS, Van Dort M, Rehemtulla A, Ross BD (2010) Targeted imaging and therapy of brain cancer using theranostic nanoparticles. Mol Pharm 7:1921–1929. https://doi.org/10.1021/mp100298r
Biswas S, Torchilin VP (2013) Dendrimers for siRNA delivery pharmaceuticals, vol 6, Basel, pp 161–183. https://doi.org/10.3390/ph6020161
Blanco E, Bey EA, Dong Y, Weinberg BD, Sutton DM, Boothman DA, Gao J (2007) Beta-lapachone-containing PEG-PLA polymer micelles as novel nanotherapeutics against NQO1-overexpressing tumor cells. J Control Release 122:365–374. https://doi.org/10.1016/j.jconrel.2007.04.014
Blau S, Jubeh TT, Haupt SM, Rubinstein A (2000) Drug targeting by surface cationization. Crit Rev Ther Drug Carrier Syst 17:425–465
Bosi S, Da Ros T, Castellano S, Banfi E, Prato M (2000) Antimycobacterial activity of ionic fullerene derivatives. Bioorg Med Chem Lett 10:1043–1045
Bullis K (2008) Shape matters for nanoparticles. MIT Technology Review https://www.technologyreview.com/s/410568/shape-matters-for-nanoparticles/
Calvo P, Remunan-Lopez C, Vila-Jato JL, Alonso MJ (1997) Chitosan and chitosan/ethylene oxide-propylene oxide block copolymer nanoparticles as novel carriers for proteins and vaccines. Pharm Res 14:1431–1436
Canelas DA, Herlihy KP, DeSimone JM (2009) Top-down particle fabrication: control of size and shape for diagnostic imaging and drug delivery. Wiley Interdiscip Rev Nanomed Nanobiotechnol 1:391–404. https://doi.org/10.1002/wnan.40
Cao YC, Jin R, Nam JM, Thaxton CS, Mirkin CA (2003) Raman dye-labeled nanoparticle probes for proteins. J Am Chem Soc 125:14676–14677. https://doi.org/10.1021/ja0366235
Carter KA, Wang S, Geng J, Luo D, Shao S, Lovell JF (2016) Metal chelation modulates phototherapeutic properties of mitoxantrone-loaded porphyrin–phospholipid liposomes. Mol Pharm 13(2):420–427
Cartiera MS, Ferreira EC, Caputo C, Egan ME, Caplan MJ, Saltzman WM (2010) Partial correction of cystic fibrosis defects with PLGA nanoparticles encapsulating curcumin. Mol Pharm 7:86–93. https://doi.org/10.1021/mp900138a
Castro E, Garcia AH, Zavala G, Echegoyen L (2017) Fullerenes in biology and medicine. J Mater Chem B 5:6523–6535. https://doi.org/10.1039/C7TB00855D
Champion JA, Mitragotri S (2006) Role of target geometry in phagocytosis. Proc Natl Acad Sci U S A 103:4930–4934. https://doi.org/10.1073/pnas.0600997103
Chan AC, Bravo Cadena M, Townley HE, Fricker MD, Thompson IP (2017) Effective delivery of volatile biocides employing mesoporous silicates for treating biofilms. J R Soc Interface 14:20160650. https://doi.org/10.1098/rsif.2016.0650
Cheng Y, Zhao L, Li Y, Xu T (2011) Design of biocompatible dendrimers for cancer diagnosis and therapy: current status and future perspectives. Chem Soc Rev 40:2673–2703. https://doi.org/10.1039/c0cs00097c
Chiang CL, Sung CS, Wu TF, Chen CY, Hsu CY (2005) Application of superparamagnetic nanoparticles in purification of plasmid DNA from bacterial cells. J Chromatogr B Anal Technol Biomed Life Sci 822:54–60. https://doi.org/10.1016/j.jchromb.2005.05.017
Cho K, Wang X, Nie S, Chen ZG, Shin DM (2008) Therapeutic nanoparticles for drug delivery in cancer. Clin Cancer Res 14:1310–1316. https://doi.org/10.1158/1078-0432.ccr-07-1441
Choi HS et al (2007) Renal clearance of nanoparticles. Nat Biotechnol 25:1165–1170. https://doi.org/10.1038/nbt1340
Das RK, Kasoju N, Bora U (2010) Encapsulation of curcumin in alginate-chitosan-pluronic composite nanoparticles for delivery to cancer cells. Nanomedicine 6:153–160. https://doi.org/10.1016/j.nano.2009.05.009
de la Isla A, Brostow W, Bujard B, Estevez M, Rodriguez JR, Vargas S, Castaño VM (2003) Nanohybrid scratch resistant coatings for teeth and bone viscoelasticity manifested in tribology. Mater Res Innov 7:110–114. https://doi.org/10.1080/14328917.2003.11784770
Decuzzi P, Godin B, Tanaka T, Lee SY, Chiappini C, Liu X, Ferrari M (2010) Size and shape effects in the biodistribution of intravascularly injected particles. J Control Release 141:320–327. https://doi.org/10.1016/j.jconrel.2009.10.014
Doshi N, Zahr AS, Bhaskar S, Lahann J, Mitragotri S (2009) Red blood cell-mimicking synthetic biomaterial particles. Proc Natl Acad Sci U S A 106:21495–21499. https://doi.org/10.1073/pnas.0907127106
Duan X, Li Y (2013) Physicochemical characteristics of nanoparticles affect circulation, biodistribution, cellular internalization, and trafficking. Small 9:1521–1532. https://doi.org/10.1002/smll.201201390
Dubertret B, Skourides P, Norris DJ, Noireaux V, Brivanlou AH, Libchaber A (2002) In vivo imaging of quantum dots encapsulated in phospholipid micelles Science, vol 298, New York, pp 1759–1762. https://doi.org/10.1126/science.1077194
Elbayoumi TA, Torchilin VP (2010) Current trends in liposome research. Methods Mol Biol 605:1–27. https://doi.org/10.1007/978-1-60327-360-2_1
El-Naggar ME, Al-Joufi F, Anwar M, Attia MF, El-Bana MA (2019) Curcumin-loaded PLA-PEG copolymer nanoparticles for treatment of liver inflammation in streptozotocin-induced diabetic rats. Colloids Surf B: Biointerfaces 177:389–398. https://doi.org/10.1016/j.colsurfb.2019.02.024
Enayati M, Ahmad Z, Stride E, Edirisinghe M (2010) One-step electrohydrodynamic production of drug-loaded micro- and nanoparticles. J R Soc Interface 7:667–675. https://doi.org/10.1098/rsif.2009.0348
Esmaeili F, Ghahremani MH, Esmaeili B, Khoshayand MR, Atyabi F, Dinarvand R (2008) PLGA nanoparticles of different surface properties: preparation and evaluation of their body distribution. Int J Pharm 349:249–255. https://doi.org/10.1016/j.ijpharm.2007.07.038
Fennimore AM, Yuzvinsky TD, Han WQ, Fuhrer MS, Cumings J, Zettl A (2003) Rotational actuators based on carbon nanotubes. Nature 424(6947):408–410
Ferguson RM, Minard KR, Krishnan KM (2009) Optimization of nanoparticle core size for magnetic particle imaging. J Magn Magn Mater 321:1548–1551. https://doi.org/10.1016/j.jmmm.2009.02.083
Florendo M, Figacz A, Srinageshwar B, Sharma A, Swanson D, Dunbar GL, Rossignol J (2018) Use of polyamidoamine dendrimers in brain diseases molecules, vol 23, Basel, p 2238. https://doi.org/10.3390/molecules23092238
Fresta M, Puglisi G, Giammona G, Cavallaro G, Micali N, Furneri PM (1995) Pefloxacine mesilate- and ofloxacin-loaded polyethylcyanoacrylate nanoparticles: characterization of the colloidal drug carrier formulation. J Pharm Sci 84:895–902
Friedman AD, Claypool SE, Liu R (2013) The smart targeting of nanoparticles. Curr Pharm Des 19:6315–6329
Galgatte UC (2017) Quantum dots: need to explore potential for delivery of drugs and biomolecules. Pharm Res 1(8):000146
Gan XW, Jiang L, Fang J, Zhao C et al (2019) Plant-inspired adhesive and tough hydrogel based on Ag-Lignin nanoparticles-triggered dynamic redox catechol chemistry. Nat Commun 10:1–10. https://doi.org/10.1038/s41467-019-09351-200026-4
Geng Y, Dalhaimer P, Cai S, Tsai R, Tewari M, Minko T, Discher DE (2007) Shape effects of filaments versus spherical particles in flow and drug delivery. Nat Nanotechnol 2:249–255. https://doi.org/10.1038/nnano.2007.70
Ghasemiyeh P, Mohammadi-Samani S (2018) Solid lipid nanoparticles and nanostructured lipid carriers as novel drug delivery systems: applications, advantages and disadvantages. Res Pharma Sci 13:288–303. https://doi.org/10.4103/1735-5362.235156
Gratton SE, Ropp PA, Pohlhaus PD, Luft JC, Madden VJ, Napier ME, DeSimone JM (2008) The effect of particle design on cellular internalization pathways. Proc Natl Acad Sci U S A 105:11613–11618. https://doi.org/10.1073/pnas.0801763105
Gref R, Minamitake Y, Peracchia MT, Trubetskoy V, Torchilin V, Langer R (1994) Biodegradable long-circulating polymeric nanospheres Science, vol 263, New York, pp 1600–1603
Gref R, Domb A, Quellec P, Blunk T, Müller RH, Verbavatz JM, Langer R (1995) The controlled intravenous delivery of drugs using PEG-coated sterically stabilized nanospheres(). Adv Drug Deliv Rev 16:215–233. https://doi.org/10.1016/0169-409X(95
Gupta AK, Curtis AS (2004) Lactoferrin and ceruloplasmin derivatized superparamagnetic iron oxide nanoparticles for targeting cell surface receptors. Biomaterials 25:3029–3040. https://doi.org/10.1016/j.biomaterials.2003.09.095
Gupta AK, Gupta M (2005) Synthesis and surface engineering of iron oxide nanoparticles for biomedical applications. Biomaterials 26:3995–4021. https://doi.org/10.1016/j.biomaterials.2004.10.012
Gupta V, Aseh A, Rios CN, Aggarwal BB, Mathur AB (2009) Fabrication and characterization of silk fibroin-derived curcumin nanoparticles for cancer therapy. Int J Nanomedicine 4:115–122
Gupta J, Fatima MT, Islam Z, Khan RH, Uversky VN, Salahuddin P (2019) Nanoparticle formulations in the diagnosis and therapy of Alzheimer’s disease. Int J Biol Macromol 130:515–526. https://doi.org/10.1016/j.ijbiomac.2019.02.156
Ha SW, Jang HL, Nam KT, Beck GR (2015) Nano-hydroxyapatite modulates osteoblast lineage commitment by stimulation of DNA methylation and regulation of gene expression. Biomaterials 65:32–42
Hahn MA, Tabb JS, Krauss TD (2005) Detection of single bacterial pathogens with semiconductor quantum dots. Anal Chem 77:4861–4869. https://doi.org/10.1021/ac050641i
Hajialyani M, Tewari D, Sobarzo-Sánchez E, Nabavi SM, Farzaei MH, Abdollahi M (2018) Natural product-based nanomedicines for wound healing purposes: therapeutic targets and drug delivery systems. Int J Nanomedicine 13:5023–5043. https://doi.org/10.2147/IJN.S174072
Hamidi M, Azadi A, Rafiei P (2008) Hydrogel nanoparticles in drug delivery. Adv Drug Deliv Rev 60:1638–1649. https://doi.org/10.1016/j.addr.2008.08.002
Han M-Y, Gao X, Su J, Nie S (2001a) Quantum-dot-tagged microbeads for multiplexed optical coding of biomolecules, vol 19. https://doi.org/10.1038/90228
Han M, Gao X, Su JZ, Nie S (2001b) Quantum-dot-tagged microbeads for multiplexed optical coding of biomolecules. Nat Biotechnol 19:631–635. https://doi.org/10.1038/90228
Hanahan D, Weinberg RA (2011) Hallmarks of cancer: the next generation. Cell 144:646–674. https://doi.org/10.1016/j.cell.2011.02.013
Hasan A, Morshed M, Memic A, Hassan S, Webster TJ, Marei HE-S (2018) Nanoparticles in tissue engineering: applications, challenges and prospects. Int J Nanomedicine 13:5637–5655. https://doi.org/10.2147/IJN.S153758
Hillaireau H, Couvreur P (2009) Nanocarriers’ entry into the cell: relevance to drug delivery. Cell Mole Life Sci 66:2873–2896. https://doi.org/10.1007/s00018-009-0053-z
Hirsch LR, Stafford RJ, Bankson JA, Sershen SR, Rivera B, Price RE, Hazle JD, Halas NJ, West JL (2003) Nanoshell-mediated near-infrared thermal therapy of tumors under magnetic resonance guidance. Proc Natl Acad Sci 100:13549–13554. https://doi.org/10.1073/pnas.2232479100
Hoffman-Amtenbrink M, Von Rechenberg B, Hofmann H (2009) Superparamagnetic nanoparticles for biomedical applications.
Hohng S, Ha T (2005) Single-molecule quantum-dot fluorescence resonance energy transfer. Chem PhysChem 6:956–960. https://doi.org/10.1002/cphc.200400557
Hu FQ, Jiang SP, Du YZ, Yuan H, Ye YQ, Zeng S (2006) Preparation and characteristics of monostearin nanostructured lipid carriers. Int J Pharm 314:83–89. https://doi.org/10.1016/j.ijpharm.2006.01.040
Hu X, Dong C, Su R, Xu Q (2016) Dinu CZ (2016) Protein self-assembly onto nanodots leads to formation of conductive bio-based hybrids. Sci Rep 6:38252. https://doi.org/10.1038/srep38252
Hu X, Fagone P, Dong C, Su R, Xu Q, Dinu CZ (2018) Biological self-assembly and recognition used to synthesize and surface guide next generation of hybrid materials. ACS Appl Mater Interfaces 10(34):28372–28381
Hutter E, Boridy S, Labrecque S, Lalancette-Hebert M, Kriz J, Winnik FM, Maysinger D (2010) Microglial response to gold nanoparticles. ACS Nano 4:2595–2606. https://doi.org/10.1021/nn901869f
Iqbal P, Preece JA, Mendes PM (2012) Nanotechnology: the “top-down” and “bottom-up” approaches. In: Supramolecular chemistry: from molecules to nanomaterials. Wiley-Blackwell, New York. https://doi.org/10.1002/9780470661345.smc195
Jaggessar A, Shahali H, Mathew A, Yarlagadda PKDV (2017) Bio-mimicking nano and micro-structured surface fabrication for antibacterial properties in medical implants. J Nanobiotechnol 15(1):64
Jain RK, Kirar P, Gupta G, Dubey S, Gupta SK, Goyal J (2009) A comparative study of low dose weekly paclitaxel versus cisplatin with concurrent radiation in the treatment of locally advanced head and neck cancers. Indian J Cancer 46:50–53
Janib SM, Moses AS, MacKay JA (2010) Imaging and drug delivery using theranostic nanoparticles. Adv Drug Deliv Rev 62:1052–1063. https://doi.org/10.1016/j.addr.2010.08.004
Jeong SY et al (2009) Systemic delivery and preclinical evaluation of Au nanoparticle containing beta-lapachone for radiosensitization. J Control Release 139:239–245. https://doi.org/10.1016/j.jconrel.2009.07.007
Ji Y, Shah S, Soanes K, Islam MN, Hoxter B, Biffo S, Heslip T, Byers S (2008) Eukaryotic initiation factor 6 selectively regulates Wnt signaling and beta-catenin protein synthesis. Oncogene 27:755–762. https://doi.org/10.1038/sj.onc.1210667
Jordan A, Scholz R, Wust P, Fähling H, Roland F (1999) Magnetic fluid hyperthermia (MFH): cancer treatment with AC magnetic field induced excitation of biocompatible superparamagnetic nanoparticles. J Magn Magn Mater 201:413–419. https://doi.org/10.1016/S0304-8853(99)00088-8
Juliano RL, Stamp D (1975) The effect of particle size and charge on the clearance rates of liposomes and liposome encapsulated drugs. Biochem Biophys Res Commun 63:651–658
Kalele SA, Ashtaputre SS, Hebalkar NY, Gosavi SW, Deobagkar DN, Deobagkar DD, Kulkarni SK (2005) Optical detection of antibody using silica–silver core–shell particles. Chem Phys Lett 404:136–141. https://doi.org/10.1016/j.cplett.2005.01.064
Kalele S, Gosavi S, Urban J, Kulkarni S ((2006)) Nanoshell particles: synthesis, properties and applications. Curr Sci:1038–1052
Kalomiraki M, Thermos K, Chaniotakis NA (2016) Dendrimers as tunable vectors of drug delivery systems and biomedical and ocular applications. Int J Nanomedicine 11:1
Kapetanovic IM, Muzzio M, Huang Z, Thompson TN, McCormick DL (2011) Pharmacokinetics, oral bioavailability, and metabolic profile of resveratrol and its dimethylether analog, pterostilbene, in rats. Cancer Chemother Pharmacol 68:593–601. https://doi.org/10.1007/s00280-010-1525-4
Khalkhali M, Mohammadinejad S, Khoeini F, Rostamizadeh K (2019) Vesicle-like structure of lipid-based nanoparticles as drug delivery system revealed by molecular dynamics simulations. Int J Pharm 559:173–181. https://doi.org/10.1016/j.ijpharm.2019.01.036
Kim Y, Meade SM, Chen K et al (2018) Nano-architectural approaches for improved intracortical interface technologies. Front Neurosci 12:1–20
Komatsu K, Murata M, Murata Y (2005) Encapsulation of molecular hydrogen in fullerene C60 by organic synthesis Science, vol 307, New York, pp 238–240
Kommareddy S, Tiwari SB, Amiji MM (2005) Long-circulating polymeric nanovectors for tumor-selective gene delivery. Technol Cancer Res Treat 4:615–625
Kroll RA, Pagel MA, Muldoon LL, Roman-Goldstein S, Fiamengo SA, Neuwelt EA (1998) Improving drug delivery to intracerebral tumor and surrounding brain in a rodent model: a comparison of osmotic versus bradykinin modification of the blood-brain and/or blood-tumor barriers. Neurosurgery 43:879–886; discussion 886-879
Kroto HW, Heath JR, O’Brien SC, Curl RF, Smalley RE (1985) C60: Buckminsterfullerene. Nature 318:162–163. https://doi.org/10.1038/318162a0
Lacroix L-M et al (2012) Tuning complex shapes in platinum nanoparticles: from cubic dendrites to fivefold stars Angewandte. Chemie International Edition 51:4690–4694. https://doi.org/10.1002/anie.201107425
Lamichhane N, Udayakumar TS, D’Souza WD, Simone CB, 2nd, Raghavan SR, Polf J, Mahmood J (2018) Liposomes: clinical applications and potential for image-guided Drug delivery Molecules 23 doi:https://doi.org/10.3390/molecules23020288
Laouini A, Jaafar-Maalej C, Limayem-Blouza I, Sfar S, Charcosset C, Fessi H (2012) Preparation, characterization and applications of liposomes: state of the art. J Colloid Sci Biotechnol 1:147–168. https://doi.org/10.1166/jcsb.2012.1020
Lee CC, MacKay JA, Frechet JM, Szoka FC (2005) Designing dendrimers for biological applications. Nat Biotechnol 23:1517–1526. https://doi.org/10.1038/nbt1171
Leo E, Scatturin A, Vighi E, Dalpiaz A (2006) Polymeric nanoparticles as drug controlled release systems: a new formulation strategy for drugs with small or large molecular weight. J Nanosci Nanotechnol 6:3070–3079
Li Q, Cai T, Huang Y, Xia X, Cole SPC, Cai Y (2017) A review of the structure, preparation, and application of NLCs, PNPs, and PLNs nanomaterials, vol 7, Basel. https://doi.org/10.3390/nano7060122
Liu M, Frechet JM (1999) Designing dendrimers for drug delivery. Pharm Sci Technol Today 2:393–401
Liu Z, Jiao Y, Wang Y, Zhou C, Zhang Z (2008) Polysaccharides-based nanoparticles as drug delivery systems. Adv Drug Deliv Rev 60:1650–1662. https://doi.org/10.1016/j.addr.2008.09.001
Liu Y, Mai S, Li N et al (2010) Differences between top-down and bottom-up approaches in mineralizing thick, partially demineralized collagen scaffolds. Acta Biomater 7(4):1742–1751. https://doi.org/10.1016/j.actbio.2010.11.028
Loo C et al (2004) Nanoshell-enabled photonics-based imaging and therapy of cancer. Technol Cancer Res Treat 3:33–40. https://doi.org/10.1177/153303460400300104
Maeda H (2001) The enhanced permeability and retention (EPR) effect in tumor vasculature: the key role of tumor-selective macromolecular drug targeting. Adv Enzym Regul 41:189–207
Magenheim B, Levy MY, Benita S (1993) A new in vitro technique for the evaluation of drug release profile from colloidal carriers - ultrafiltration technique at low pressure. Int J Pharm 94:115–123. https://doi.org/10.1016/0378-5173(93)90015-8
Markovic Z, Trajkovic V (2008) Biomedical potential of the reactive oxygen species generation and quenching by fullerenes (C60). Biomaterials 29:3561–3573
McClements DJ (2015) Nanoscale nutrient delivery systems for food applications: improving bioactive dispersibility, stability, and bioavailability. J Food Sci 80:N1602–N1611. https://doi.org/10.1111/1750-3841.12919
McNamara K, Tofail SAM (2017) Nanoparticles in biomedical applications. Adv Phys: X 2:54–88. https://doi.org/10.1080/23746149.2016.1254570
Mhlwatika Z, Aderibigbe BA (2018) Application of dendrimers for the treatment of infectious diseases molecules, vol 23, Basel, p 2205. https://doi.org/10.3390/molecules23092205
Moghimi SM, Hunter AC, Murray JC (2001) Long-circulating and target-specific nanoparticles: theory to practice. Pharmacol Rev 53:283–318
Mohanraj V, Chen Y (2006) Nanoparticles-a review. Trop J Pharm Res 5:561–573
Mroz P, Pawlak A, Satti M, Lee H, Wharton T, Gali H, Sarna T, Hamblin MR (2007a) Functionalized fullerenes mediate photodynamic killing of cancer cells: type I versus Type II photochemical mechanism. Free Radic Biol Med 43:711–719. https://doi.org/10.1016/j.freeradbiomed.2007.05.005
Mroz P, Tegos GP, Gali H, Wharton T, Sarna T, Hamblin MR (2007b) Photodynamic therapy with fullerenes Photochemical & photobiological sciences. Official J Euro Photochem Assoc Euro Soc Photobiol 6:1139–1149. https://doi.org/10.1039/b711141j
Mudshinge SR, Deore AB, Patil S, Bhalgat CM (2011) Nanoparticles: emerging carriers for drug delivery. Saudi Pharma J 19:129–141. https://doi.org/10.1016/j.jsps.2011.04.001
Mukerjee A, Vishwanatha JK (2009) Formulation, characterization and evaluation of curcumin-loaded PLGA nanospheres for cancer therapy. Anticancer Res 29:3867–3875
Mukherjee S, Ray S, Thakur RS (2009) Solid lipid nanoparticles: a modern formulation approach in drug delivery system. Indian J Pharm Sci 71:349–358. https://doi.org/10.4103/0250-474X.57282
Mulik RS, Monkkonen J, Juvonen RO, Mahadik KR, Paradkar AR (2010) ApoE3 mediated poly(butyl) cyanoacrylate nanoparticles containing curcumin: study of enhanced activity of curcumin against beta amyloid induced cytotoxicity using in vitro cell culture model. Mol Pharm 7:815–825. https://doi.org/10.1021/mp900306x
Müller K, Bugnicourt E, Latorre M, Jorda M, Echegoyen Sanz Y, Lagaron J, Miesbauer O, Bianchin A, Hankin S, Bölz U, Pérez G (2017) Review on the processing and properties of polymer nanocomposites and nanocoatings and their applications in the packaging, automotive and solar energy fields. Nanomaterials 7(4):1–47
Muro M, Jeffrey P (2008) A critical review of the theory and application of social learning in participatory natural resource management processes. J Environ Plan Manag 51:325–344. https://doi.org/10.1080/09640560801977190
Muro S, Garnacho C, Champion JA, Leferovich J, Gajewski C, Schuchman EH, Mitragotri S, Muzykantov VR (2008) Control of endothelial targeting and intracellular delivery of therapeutic enzymes by modulating the size and shape of ICAM-1-targeted carriers Molecular therapy : J Am Soc Gene Ther 16:1450-1458 doi:https://doi.org/10.1038/mt.2008.127
Murugesan S, Mousa SA, O’Connor LJ, Lincoln DW, Linhardt RJ (2007) Carbon inhibits vascular endothelial growth factor- and fibroblast growth factor-promoted angiogenesis. FEBS Lett 581:1157–1160. https://doi.org/10.1016/j.febslet.2007.02.022
Nagpal K, Singh SK, Mishra DN (2010) Chitosan nanoparticles: a promising system in novel drug delivery. Chem Pharm Bull 58:1423–1430
Narayanan R (2012) Nanoparticles of different shapes for biosensor applications. In: Functional Nanoparticles for Bioanalysis, Nanomedicine, and Bioelectronic Devices Volume 1, ACS Symposium Series, vol 1112. American Chemical Society, pp 281–292
Natarajan J, Karri V, Anindita D (2017) Nanostructured Lipid Carrier (NLC): a promising drug delivery system. Glob J Nano 1(5). https://doi.org/10.19080/GJN.2017.01.555575
Nel AE, Mädler L, Velegol D, Xia T, Hoek EMV, Somasundaran P, Klaessig F, Castranova V, Thompson M (2009) Understanding biophysicochemical interactions at the nano-bio interface. Nat Mater 8:543–557. https://doi.org/10.1038/nmat2442
Neves AR, Queiroz JF, Reis S (2016) Brain-targeted delivery of resveratrol using solid lipid nanoparticles functionalized with apolipoprotein E. J Nanobiotechnol 14:27. https://doi.org/10.1186/s12951-016-0177-x
Nowacek AS, McMillan J, Miller R, Anderson A, Rabinow B, Gendelman HE (2010) Nanoformulated antiretroviral drug combinations extend drug release and antiretroviral responses in HIV-1-infected macrophages: implications for neuroAIDS therapeutics Journal of neuroimmune pharmacology. Offic J Soc NeuroImmune Pharmacol 5:592–601. https://doi.org/10.1007/s11481-010-9198-7
Panao Costa J, Carvalho S, Jesus S, Soares E, Marques AP, Borges O (2019) Optimization of chitosan-alpha-casein nanoparticles for improved gene delivery: characterization, stability, and transfection efficiency. AAPS Pharm Sci Tech 20:132. https://doi.org/10.1208/s12249-019-1342-y
Panyam J, Labhasetwar V (2003) Biodegradable nanoparticles for drug and gene delivery to cells and tissue. Adv Drug Deliv Rev 55:329–347
Pareek V, Bhargava A, Gupta R, Jain N, Panwar J (2017) Synthesis and applications of noble metal nanoparticles: a review. Adv Sci Eng Med 9:527–544. https://doi.org/10.1166/asem.2017.2027
Park JW (2002) Liposome-based drug delivery in breast cancer treatment. Breast Cancer Res 4:95–99
Park JH, von Maltzahn G, Zhang L, Schwartz MP, Ruoslahti E, Bhatia SN, Sailor MJ (2008) Magnetic iron oxide nanoworms for tumor targeting and imaging. Adv Mater 20:1630–1635. https://doi.org/10.1002/adma.200800004
Pathak S, Choi SK, Arnheim N, Thompson ME (2001) Hydroxylated quantum dots as luminescent probes for in situ hybridization. J Am Chem Soc 123:4103–4104
Pattekari P, Zheng Z, Zhang X, Levchenko T, Torchilin V, Lvov Y (2011) Top-down and bottom-up approaches in production of aqueous nanocolloids of low solubility drug paclitaxel. Phys Chem Chem Phys 13(19):9014–9019. https://doi.org/10.1039/c0cp02549f
Pelicano H, Martin DS, Xu RH, Huang P (2006) Glycolysis inhibition for anticancer treatment. Oncogene 25:4633–4646. https://doi.org/10.1038/sj.onc.1209597
Petros RA, DeSimone JM (2010) Strategies in the design of nanoparticles for therapeutic applications. Nat Rev Drug Discov 9:615–627. https://doi.org/10.1038/nrd2591
Pu X et al (2019) A polymeric micelle with an endosomal pH-sensitivity for intracellular delivery and enhanced antitumor efficacy of hydroxycamptothecin. Acta Biomater. https://doi.org/10.1016/j.actbio.2019.02.039
Qi L, Gao X (2008) Emerging application of quantum dots for drug delivery and therapy. Expert Opin Drug Deliv 5:263–267
Rabinow BE (2004) Nanosuspensions in drug delivery. Nat Rev Drug Discov 3:785. https://doi.org/10.1038/nrd1494
Ramos AP, Cruz MAE, Tovani CB, Ciancaglini P (2017) Biomedical applications of nanotechnology. Biophys Rev 9:79–89. https://doi.org/10.1007/s12551-016-0246-2
Rao KS, Ghorpade A, Labhasetwar V (2009) Targeting anti-HIV drugs to the CNS. Expert Opin Drug Deliv 6:771–784. https://doi.org/10.1517/17425240903081705
Rastegari A, Mottaghitalab F, Dinarvand R, Amini M, Arefian E, Gholami M, Atyabi F (2019) Inhibiting hepatic gluconeogenesis by chitosan lactate nanoparticles containing CRTC2 siRNA targeted by poly(ethylene glycol)-glycyrrhetinic acid. Drug Deliv Transl Res. https://doi.org/10.1007/s13346-019-00618-1
Rastogi V, Yadav P, Bhattacharya SS, Mishra AK, Verma N, Verma A, Pandit JK (2014) Carbon nanotubes: an emerging drug carrier for targeting cancer cells. J Drug Deliv 670815:1–23. https://doi.org/10.1155/2014/670815
Redhead HM, Davis SS, Illum L (2001) Drug delivery in poly(lactide-co-glycolide) nanoparticles surface modified with poloxamer 407 and poloxamine 908: in vitro characterisation and in vivo evaluation. J Control Release 70:353–363
Rizvi SAA, Saleh AM (2018a) Applications of nanoparticle systems in drug delivery technology Saudi pharmaceutical journal : SPJ. Saudi Pharm Soc 26:64–70. https://doi.org/10.1016/j.jsps.2017.10.012
Rizvi SAA, Saleh AM (2018b) Applications of nanoparticle systems in drug delivery technology. Saudi Pharm J 26:64–70. https://doi.org/10.1016/j.jsps.2017.10.012
Rizvi SB, Ghaderi S, Keshtgar M, Seifalian AM (2010) Semiconductor quantum dots as fluorescent probes for in vitro and in vivo bio-molecular and cellular imaging Nano Reviews, vol 1. https://doi.org/10.3402/nano.v1i0.5161
Roser M, Fischer D, Kissel T (1998) Surface-modified biodegradable albumin nano- and microspheres. II: effect of surface charges on in vitro phagocytosis and biodistribution in rats. Eur J Pharm Biopharm 46:255–263
Sahu A, Kasoju N, Bora U (2008) Fluorescence study of the curcumin-casein micelle complexation and its application as a drug nanocarrier to cancer cells. Biomacromolecules 9:2905–2912. https://doi.org/10.1021/bm800683f
Salata OV (2004) Applications of nanoparticles in biology and medicine. J Nanobiotechnol 2:3. https://doi.org/10.1186/1477-3155-2-3
Sanginario A, Miccoli B, Demarchi D (2017) Carbon nanotubes as an effective opportunity for cancer diagnosis and treatment. Biosensors 7:9. https://doi.org/10.3390/bios7010009
Saovapakhiran A, D’Emanuele A, Attwood D, Penny J (2009) Surface modification of PAMAM dendrimers modulates the mechanism of cellular internalization. Bioconjug Chem 20:693–701. https://doi.org/10.1021/bc8002343
Schäffler M et al (2013) Serum protein identification and quantification of the corona of 5, 15 and 80 nm gold nanoparticles. Nanotechnology 24:265103. https://doi.org/10.1088/0957-4484/24/26/265103
Schipper ML et al (2009) Particle size, surface coating, and PEGylation influence the biodistribution of quantum dots in living mice. Small 5:126–134. https://doi.org/10.1002/smll.200800003
Schumann H, Wassermann BC, Schutte S, Velder J, Aksu Y, Krause W, Radüchel B (2003) Synthesis and characterization of water-soluble tin-based metallodendrimers. Organometallics 22:2034–2041
Schwerdtfeger P, Wirz LN, Avery J (2015) The topology of fullerenes. Wiley Interdiscip Rev Comput Mol Sci 5:96–145. https://doi.org/10.1002/wcms.1207
Shanmuganathan R, Edison T, LewisOscar F, Ponnuchamy K, Shanmugam S, Pugazhendhi A (2019) Chitosan nanopolymers: an overview of drug delivery against cancer. Int J Biol Macromol 130:727–736. https://doi.org/10.1016/j.ijbiomac.2019.02.060
Sharma G, Kumar A (eds) (2018) Carbonaceous composite materials. Materials Research Forum LLC, Yew York
Shen B, Ma Y, Yu S, Ji C (2016) Smart multifunctional magnetic nanoparticle-based drug delivery system for cancer thermo-chemotherapy and intracellular imaging. ACS Appl Mater Interfaces 8:24502–24508. https://doi.org/10.1021/acsami.6b09772
Siddiqui IA, Adhami VM, Bharali DJ, Hafeez BB, Asim M, Khwaja SI, Ahmad N, Cui H, Mousa SA, Mukhtar H (2009) Introducing nanochemoprevention as a novel approach for cancer control: proof of principle with green tea polyphenol epigallocatechin-3-gallate. Cancer Res 69:1712–1716. https://doi.org/10.1158/0008-5472.can-08-3978
Silva A, Santos D, Ferreira D, Souto E (2009) Minoxidil-loaded nanostructured lipid carriers (NLC): characterization and rheological behaviour of topical formulations. Die Pharmazie-An Int J Pharm Sci 64:177–182
Singh R, Lillard JW (2009) Nanoparticle-based targeted drug delivery. Exp Mol Pathol 86:215–223. https://doi.org/10.1016/j.yexmp.2008.12.004
Smith AM, Dave S, Nie S, True L, Gao X (2006) Multicolor quantum dots for molecular diagnostics of cancer. Expert Rev Mol Diagn 6:231–244
Somani S, Blatchford DR, Millington O, Stevenson ML, Dufes C (2014) Transferrin-bearing polypropylenimine dendrimer for targeted gene delivery to the brain. J Control Release 188:78–86. https://doi.org/10.1016/j.jconrel.2014.06.006
Souto EB, Almeida A, Müller RH (2007) Lipid nanoparticles (SLN®, NLC®) for cutaneous drug delivery:structure, protection and skin effects, vol 3. https://doi.org/10.1166/jbn.2007.049
Suñé-Pou M, Prieto-Sánchez S, el Yousfi Y, Boyero-Corral S, Nardi-Ricart A, Nofrerias-Roig I, Pérez-Lozano P, García-Montoya E, Miñarro-Carmona M, Ticó JR, Suñé-Negre JM, Hernández-Munain C, Suñé C (2018) Cholesteryl oleate-loaded cationic solid lipid nanoparticles as carriers for efficient gene-silencing therapy. Int J Nanomedicine 13:3223–3233. https://doi.org/10.2147/IJN.S158884
Tan JPK et al (2019) Effective encapsulation of apomorphine into biodegradable polymeric nanoparticles through a reversible chemical bond for delivery across the blood-brain barrier Nanomedicine. Nanotechnol Biol Med. https://doi.org/10.1016/j.nano.2019.01.014
Tegos GP, Demidova TN, Arcila-Lopez D, Lee H, Wharton T, Gali H, Hamblin MR (2005) Cationic fullerenes are effective and selective antimicrobial photosensitizers. Chem Biol 12:1127–1135. https://doi.org/10.1016/j.chembiol.2005.08.014
The Royal Society (2004) Nanoscience and nanotechnologies: opportunities and uncertainties. Royal Society: London
Tian X, Zhang L, Yang M, Bai L, Dai Y, Yu Z, Pan Y (2018) Functional magnetic hybrid nanomaterials for biomedical diagnosis and treatment. Wiley Interdiscip Rev: Nanomed Nanobiotechnol 10(1):e1476. https://doi.org/10.1002/wnan.1476
Uddin MS (2019) Nanoparticles as nanopharmaceuticals: a smart drug delivery system. In: Keservani RK, Sharma AK (eds) Nanoparticulate Drug Delivery Systems. 1st ed. Apple Academic Press, USA
Valdes C, Bustos G, Martinez JL, Laurido C (2018) Antinociceptive antibiotics-loaded into solid lipid nanoparticles of prolonged release: measuring pharmacological efficiency and time span on chronic monoarthritis rats. PLoS One 13:e0187473. https://doi.org/10.1371/journal.pone.0187473
Verma A, Stellacci F (2010) Effect of surface properties on nanoparticle-cell interactions. Small 6:12–21. https://doi.org/10.1002/smll.200901158
Walle T (2011) Bioavailability of resveratrol. Ann N Y Acad Sci 1215:9–15. https://doi.org/10.1111/j.1749-6632.2010.05842.x
Wang W et al (2018) Curcumin-loaded solid lipid nanoparticles enhanced anticancer efficiency in breast cancer molecules, vol 23, Basel, p 1578. https://doi.org/10.3390/molecules23071578
Whitesides GM (2003) The 'right' size in nanobiotechnology. Nat Biotechnol 21:1161. https://doi.org/10.1038/nbt872
Wiener E, Brechbiel MW, Brothers H, Magin RL, Gansow OA, Tomalia DA, Lauterbur PC (1994) Dendrimer-based metal chelates: a new class of magnetic resonance imaging contrast agents. Magn Reson Med 31:1–8. https://doi.org/10.1002/mrm.1910310102
Woeppel K, Zheng XS, Cui XT (2018). Enhancing surface immobilization of bioactive molecule via silica nanoparticle base coating. J Mater Chem B 28:1605035.
Xia Y, Whitesides GM (1998) Soft lithography Angewandte Chemie International Edition 16. Soft Lithography 37(5):550–575
Xiao K, Li Y, Luo J, Lee JS, Xiao W, Gonik AM, Agarwal RG, Lam KS (2011) The effect of surface charge on in vivo biodistribution of PEG-oligocholic acid based micellar nanoparticles. Biomaterials 32:3435–3446. https://doi.org/10.1016/j.biomaterials.2011.01.021
Xu F, Yuan Y, Shan X, Liu C, Tao X, Sheng Y, Zhou H (2009) Long-circulation of hemoglobin-loaded polymeric nanoparticles as oxygen carriers with modulated surface charges. Int J Pharm 377:199–206. https://doi.org/10.1016/j.ijpharm.2009.05.015
Xu W, Bae EJ, Lee M-K (2018) Enhanced anticancer activity and intracellular uptake of paclitaxel-containing solid lipid nanoparticles in multidrug-resistant breast cancer cells. Int J Nanomedicine 13:7549–7563. https://doi.org/10.2147/IJN.S182621
Yadav D, Sandeep K, Pandey D, Dutta RK (2017) Liposomes for drug delivery. J Biotechnol Biomat 07. https://doi.org/10.4172/2155-952x.1000276
Yamamoto Y, Nagasaki Y, Kato Y, Sugiyama Y, Kataoka K (2001) Long-circulating poly(ethylene glycol)-poly(D,L-lactide) block copolymer micelles with modulated surface charge. J Control Release 77:27–38
Yatvin MB, Kreutz W, Horwitz BA, Shinitzky M (1980) pH-sensitive liposomes: possible clinical implications Science, vol 210, New York, pp 1253–1255
Yoo JW, Doshi N, Mitragotri S (2010) Endocytosis and intracellular distribution of PLGA particles in endothelial cells: effect of particle geometry macromolecular rapid communications 31:142–148. https://doi.org/10.1002/marc.200900592
Yoo J, Noh M, Kim H, Jeon NL, Kim B-S, Kim J (2015) Nanogrooved substrate promotes direct lineage reprogramming of fibroblasts to functional induced dopaminergic neurons. Biomaterials 45:36–45
Yu Y, Xu Q, He S, Xiong H, Zhang Q, Xu W, Ricotta V, Bai L, Zhang Q, Yu Z, Ding J (2019) Recent advances in delivery of photosensitive metal-based drugs. Coord Chem Rev 387:154–179
Zahr AS, Davis CA, Pishko MV (2006) Macrophage uptake of core-shell nanoparticles surface modified with poly(ethylene glycol). Langmuir 22:8178–8185. https://doi.org/10.1021/la060951b
Zepeda-Cervantes J, Cruz-Resendiz A, Sampieri A, Carreon-Napoles R, Sanchez-Betancourt JI, Vaca L (2019) Incorporation of ORF2 from porcine circovirus type 2(PCV2) into genetically encoded nanoparticles as a novel vaccine using a self-aggregating peptide. Vaccine 37:1928–1937. https://doi.org/10.1016/j.vaccine.2019.02.044
Zhang Q, Ai X, Wang L, Chang Y, Luo W, Jiang W, Chen L (2015) Improved thermoelectric performance of silver nanoparticles-dispersed Bi2Te3 composites deriving from hierarchical two-phased heterostructure. Adv Funct Mater 25(6):966–976
Funding
The author(s) received no financial support for the research, authorship, and publication of this manuscript.
Author information
Authors and Affiliations
Contributions
This work was carried out in collaboration between all authors. MSU designed the study, wrote the protocol, and managed the analyses of the study. NZ, RA, and MTK prepared the draft of the manuscript. DT, BM, MSU, and MTK and revised and improved the manuscript. MSU, LA, and MMA-D reviewed the scientific contents of the manuscript. All the authors read and approved the final manuscript.
Corresponding author
Ethics declarations
Conflict of interest
The authors declare that they have no conflict of interest.
Additional information
Responsible editor: Philippe Garrigues
Publisher’s note
Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
Rights and permissions
About this article
Cite this article
Zahin, N., Anwar, R., Tewari, D. et al. Nanoparticles and its biomedical applications in health and diseases: special focus on drug delivery. Environ Sci Pollut Res 27, 19151–19168 (2020). https://doi.org/10.1007/s11356-019-05211-0
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s11356-019-05211-0