Association between DNA damage, dietary patterns, nutritional status, and non-communicable diseases in coal miners

dos Santos, Marina; Penteado, Júlia Oliveira; Soares, Maria Cristina Flores; Muccillo-Baisch, Ana Luíza; Da Silva-Júnior, Flávio Manoel Rodrigues

doi:10.1007/s11356-019-04922-8

Research Article
Published: 03 April 2019

Association between DNA damage, dietary patterns, nutritional status, and non-communicable diseases in coal miners

Marina dos Santos^1,2,
Júlia Oliveira Penteado^1,2,
Maria Cristina Flores Soares^1,2,
Ana Luíza Muccillo-Baisch^1,2 &
Flávio Manoel Rodrigues Da Silva-Júnior ORCID: orcid.org/0000-0002-7344-4679^1,2

Environmental Science and Pollution Research volume 26, pages 15600–15607 (2019)Cite this article

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Abstract

Several negative health effects have been associated with environmental pollution. Coal mining activities are related to DNA damage. However, the impact of lifestyle as well as environmental exposure must be considered when evaluating the extent of DNA damage. The aim of this cross-sectional study was to analyze nutritional status, dietary patterns, and the prevalence of non-communicable diseases (CNCDs) among coal miners as well as to investigate the correlation of these variables with DNA damage. We used a questionnaire to assess demographics, health, and dietary habits. The nutritional status was measured in terms of BMI (body mass index) and DNA damage was assessed by the comet assay. The sample population was composed of 158 coal miners from the largest coal mining company in South of Brazil, and majority of them were classified as overweight (51.3%) or obese (28.5%). Hypertension was the most common CNCD (50.6%) and a majority of these workers consumed all groups of foods three or more times a week. There was a significant positive correlation between BMI and DNA damage (r = 0.1646, p = 0.04) and this association was stronger (r = 0.2556, p = 0.04) in coal miners with some CNCD. There was no significant correlation between dietary patterns and DNA damage in coal miners. These results suggest that the nutritional status and CNCD increase the extent of DNA damage in coal miners. Since this population is at high occupational risk, specific strategies should be designed to improve the health of these workers, aiming to achieve health equity.

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Funding

This study was financed in part by the Coordenação de Aperfeiçoamento de Pessoal de Nível Superior—Brasil (CAPES) —Finance Code 001, and by the Companhia Riograndense de Mineração.

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Programa de Pós-Graduação em Ciências Da Saúde, Faculdade de Medicina, Universidade Federal do Rio Grande, Rua Visconde de Paranaguá, 102, Rio Grande, 96203-900, Brazil
Marina dos Santos, Júlia Oliveira Penteado, Maria Cristina Flores Soares, Ana Luíza Muccillo-Baisch & Flávio Manoel Rodrigues Da Silva-Júnior
Laboratório de Ensaios Farmacológicos e Toxicológicos, Instituto de Ciências Biológicas, Universidade Federal do Rio Grande, Avenida Itália, km 8, Rio Grande, 96203-900, Brazil
Marina dos Santos, Júlia Oliveira Penteado, Maria Cristina Flores Soares, Ana Luíza Muccillo-Baisch & Flávio Manoel Rodrigues Da Silva-Júnior

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Marina dos Santos
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Júlia Oliveira Penteado
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Maria Cristina Flores Soares
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Ana Luíza Muccillo-Baisch
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Flávio Manoel Rodrigues Da Silva-Júnior
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dos Santos, M., Penteado, J.O., Soares, M.C.F. et al. Association between DNA damage, dietary patterns, nutritional status, and non-communicable diseases in coal miners. Environ Sci Pollut Res 26, 15600–15607 (2019). https://doi.org/10.1007/s11356-019-04922-8

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Received: 16 October 2018
Accepted: 20 March 2019
Published: 03 April 2019
Issue Date: 01 May 2019
DOI: https://doi.org/10.1007/s11356-019-04922-8

Keywords

Comet assay
Genotoxicity
Body mass index
Dietary intake