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The content of toxic and essential elements in trabecular and cortical femoral neck: a correlation with whole blood samples

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Abstract

Pollution caused by heavy metals affects all forms of life. The aim of the study was to determine the content of toxic (Sr, Ni, Pb, V, Cd, U, Rb, As) and essential (Na, K, Ca, Mg, Zn, Cu, Se, Mn, Cr, Mo, Co) metals in the bone and whole blood samples, in regard to clinical means of long- and short-term exposure, respectively. For this purpose, the cortical and trabecular parts of femoral neck, as well as the blood samples, were collected to quantify bone-important metals by inductively coupled plasma (ICP)-based techniques. According to principal component analysis (PCA), the most influential metal discriminating blood samples was Cu, while all other quantified elements were present in higher amounts in the bones. Additionally, trabecular bones (TBs) could be characterized by higher content of Mo, Cr, V, Mn, Co, As, and Ni compared to cortical bones (CBs). Linear discrimination analysis (LDA) was successfully applied to distinguish trabecular bone from the cortical bone. Significant correlation between essential Ca and toxic Sr with other elements was found and discussed. This study provides novel data on the effects of metal pollutants on bone health hazards. The results obtained for investigating metals may serve as a baseline for further clinical investigations in the orthopedic fields.

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References

  • Aaseth J, Boivin G, Andersen O (2012) Osteoporosis and trace elements – an overview. J Trace Elem Med Biol 26:149–152

    Article  CAS  Google Scholar 

  • Alghadir AH, Gabr SA, Al-Eisa ES, Alghadir MH (2016) Correlation between bone mineral density and serum trace elements in response to supervised aerobic training in older adults. Clin Interv Aging 11:265–273

    CAS  Google Scholar 

  • Arzuaga X, Gehlhaus M, Strong J (2015) Modes of action associated with uranium induced adverse effects in bone function and development. Toxicol Lett 236:123–130

    Article  CAS  Google Scholar 

  • Brodziak-Dopierala B, Kwapulinski J, Gajda Z, Toborek J, Bogunia M (2006) Changes of heavy metal concentrations in cross-sections of human femur head. Biol Trace Elem Res 144:107–114

    Article  Google Scholar 

  • Brodziak-Dopierala B, Kwapulinski J, Sobczyk K, Wiechula D (2015) Analysis of the content of cadmium and zinc in parts of the human hip joint. Biol Trace Elem Res 163:73–80

    Article  CAS  Google Scholar 

  • Budis H, Kalisinska E, Lanocha N, Kosik-Bogacka D, Sokolowski S, Dobiecki K, Kolodziej L, Bohatyrewicz A (2014) The concentration of manganese, iron, and strontium in hip joint bone obtained from patients undergoing hip replacement surgery. J Trace Elem Med Biol 28:39–44

    Article  CAS  Google Scholar 

  • Cashman KD (2006) Milk minerals (including trace elements) and bone health. Int Dairy J 16:1389–1398

    Article  CAS  Google Scholar 

  • Chew LT, Bradley DA, Mohd AY, Jamil MM (2000) Zinc, lead and copper in human teeth measured by induced coupled argon plasma atomic emission spectroscopy (ICP-AES). Appl Radiat Isot 53:633–638

    Article  CAS  Google Scholar 

  • Choi HJ, Lim SJ, Park YS, Lee SY (2015) Simple and robust ICP-MS method for simultaneous determination of serum co and Cr in routine clinical practice. Clin Chim Acta 439:91–96

    Article  CAS  Google Scholar 

  • Dermience M, Lognay G, Mathieu F, Goyens P (2015) Effects of thirty elements on bone metabolism. J Trace Elem Med Biol 32:86–106

    Article  CAS  Google Scholar 

  • Helliwell TR, Kelly SA, Walsh HPJ, Klenerman L, Haines J, Clark R, Roberts NB (1996) Elemental analysis of femoral bone from patients with fractured neck of femur or osteoarthritis. Bone 18:151–157

    Article  CAS  Google Scholar 

  • Hirayama M, Iijima S, Iwashita M, Akiyama S, Takaku Y, Yamazaki M, Omari T, Yumoto S, Shimamura T (2011) Aging effects of major and trace elements in rat bones and their mutual correlations. J Trace Elem Med Biol 25:73–84

    Article  CAS  Google Scholar 

  • Jurkiewicz A, Wiechula D, Nowak R, Gazdzik T, Loska K (2004) Metal content in femoral head spongious bone of people living in regions of different degrees of environmental pollution in southern and middle Poland. Ecotoxicol Environ Saf 59:95–101

    Article  CAS  Google Scholar 

  • Karaaslan F, Mutlu M, Mermerkaya MU, Karaoglu S, Sacmaci S, Kartal S (2014) Comparison of bone tissue trace-element concentrations and mineral density in osteoporotic femoral neck fractures and osteoarthritis. Clin Interv Aging 9:1375–1382

    Article  CAS  Google Scholar 

  • Kern J, Mathiason L (2012) The determination of copper, zinc, and lead in human teeth using inductively coupled plasma atomic emission spectrometry (ICP-AES). CCJAC 3:33–39

    Google Scholar 

  • Kubaszewski L, Ziola-Frankowska A, Frankowski M, Rogala P, Gasik Z, Kaczmarczyk J, Nowakowski A, Dabrowski M, Labedz W, Miekisiak G, Gasik R (2014) Comparison of trace element concentration in bone and intervertebral disc tissue by atomic absorption spectrometry techniques. J Orthop Surg Res 9:1–8

    Article  Google Scholar 

  • Kuo HW, Kuo SM, Chou CH, Lee TC (2000) Determination of 14 elements in Taiwanese bones. Sci Total Environ 255:45–54

    Article  CAS  Google Scholar 

  • Lanocha N, Kalisinska E, Kosik-Bogacka DI, Budis H, Sokolowski S, Bohatyrewicz A (2012) Concentrations of trace elements in bones of the hip joint from patients after hip replacement surgery. J Trace Elem Med Biol 26:20–25

    Article  CAS  Google Scholar 

  • Miller JN, Miller JC (2010) Statistics and Chemometrics for analytical chemistry. Pearson Education Limited, Harlow

    Google Scholar 

  • Parr RM, Dey A, McCloskey EV, Aras N, Balogh A, Borelli A, Krishnan S, Lobo G, Qin LL, Zhang Y, Cvijetic S, Zaichick V, Lim-Abraham M, Bose K, Wynchanck S, Iyengar GV (2002) Contribution of calcium and other dietary components to global variations in bone mineral density in young adults. Food Nutr Bull 23:180–184

    Article  CAS  Google Scholar 

  • Roberts NB, Walsh HPJ, Klenerman L, Kelly SA, Helliwell TR (1996) Determination of elements in human femoral bone using inductively coupled plasma atomic emission spectrometry and inductively coupled plasma mass spectrometry. J Anal Atom Spectrom 11:133–138

    Article  CAS  Google Scholar 

  • Roczniak W, Bradziak-Dopierala B, Cipola E, Mitko K, Jakobik-Kolon A, Konieczny M, Babuska-Roczniak M (2017) The content of structural and trace elements in the knee joint tissues. Int J Environ Res Public Health 14:1–13

    Article  CAS  Google Scholar 

  • Scharf B, Clement CC, Zolla V, Perino G, Yan B, Elci SG, Purdue E, Goldring S, Macaluso F, Cobelli N, Vachet RW, Santambrogio L (2014) Molecular analysis of chromium and cobalt-related toxicity. Sci Rep 4:1–12

    Google Scholar 

  • Takata MK, Saiki M, Sumita NM, Saldiva PHN, Pasqualucci CA (2005) Trace element determinations in human cortical and trabecular bones. J Radioanal Nucl Chem 264:5–8

    Article  CAS  Google Scholar 

  • Tandon L, Iyengar GV, Parr RM (1998) A review of radiologically important trace elements in human bones. Appl Radiat Isot 49:903–910

    Article  CAS  Google Scholar 

  • Zaichick V (2006) INAA of ca, cl, K, mg, Mn, Na, P, and Sr contents in the human cortical and trabecular bone. J Radioanal Nucl Chem 269:653–659

    Article  CAS  Google Scholar 

  • Zaichick S, Zaichick V (2010) The effect of age and gender on 38 chemical element contents in human iliac crest investigated by instrumental neutron activation analysis. J Trace Elem Med Biol 24:1–6

    Article  CAS  Google Scholar 

  • Zaichick V, Zaichick S (2018) Significance of trace elements quantities in osteomyelitis and osteosarcoma. Nov Appro Can Stud 1:1–11

    Google Scholar 

  • Zamburlini M, Campbell JL, de Silveira G, Butler R, Pejović-Milić A, Chettle DR (2009) Strontium depth distribution in human bone measured by micro-PIXE. X-Ray Spectrom 38:271–277

    Article  CAS  Google Scholar 

  • Ziola-Frankowska A, Kubaszewski L, Dabrowski M, Kolowalski A, Rogala P, Strzyzewski W, Labedz W, Uklejewski R, Novotny K, Kanicky V, Frankowski M (2015) The content of the 14 metals in cancellous and cortical bone of the hip joint affected by osteoarthritis. Biomed Res Int 1:1–23

    Article  CAS  Google Scholar 

  • Zofkova I, Davis M, Blahos J (2017) Trace elements have beneficial, as well as detrimental effects on bone homeostasis. Physiol Res 66:391–402

    CAS  Google Scholar 

Download references

Funding

This research was financially supported by the Ministry of Education, Science and Technological Development of the Republic of Serbia, project No. 172030.

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Authors and Affiliations

  1. University of Belgrade – Faculty of Chemistry, Studentski trg 12-16, 11000, Belgrade, Serbia

    Aleksandar Stojsavljević, Sandra Škrivanj, Jelena Trifković & Dragan Manojlović

  2. Clinical Centre of Kragujevac, Zmaj Jovina 30, 34000, Kragujevac, Serbia

    Nenad Djoković

  3. Faculty of Science, Department of Chemistry, University of Kragujevac, Radoja Domanovića 12, 34000, Kragujevac, Serbia

    Srećko R Trifunović

  4. Department of Physiology, Institute for Biological Research “Siniša Stanković”, University of Belgrade, Bulevar despota Stefana 142, Belgrade, 11060, Serbia

    Slavica Borković-Mitić

  5. South Ural State University, Chelyabinsk, Lenin prospect 76, 454080, Russia

    Dragan Manojlović

Authors
  1. Aleksandar Stojsavljević
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  2. Sandra Škrivanj
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  3. Jelena Trifković
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  4. Nenad Djoković
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  5. Srećko R Trifunović
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  6. Slavica Borković-Mitić
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  7. Dragan Manojlović
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Corresponding author

Correspondence to Aleksandar Stojsavljević.

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The study was approved by the Ethics Committee of Clinical Centre Kragujevac, Serbia. All subjects voluntarily participated in the study and the consent was obtained from each subject.

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The authors declare that they have no conflict of interest.

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Responsible editor: Philippe Garrigues

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Stojsavljević, A., Škrivanj, S., Trifković, J. et al. The content of toxic and essential elements in trabecular and cortical femoral neck: a correlation with whole blood samples. Environ Sci Pollut Res 26, 16577–16587 (2019). https://doi.org/10.1007/s11356-019-04796-w

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  • DOI: https://doi.org/10.1007/s11356-019-04796-w

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