Bisphenol S exposure affects gene expression related to intestinal glucose absorption and glucose metabolism in mice
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Bisphenol S, an industrial chemical, has raised concerns for both human and ecosystem health. Yet, health hazards posed by bisphenol S (BPS) exposure remain poorly studied. Compared to all tissues, the intestine and the liver are among the most affected by environmental endocrine disruptors. The aim of this study was to investigate the molecular effect of BPS on gene expression implicated in the control of glucose metabolism in the intestine (apelin and its receptor APJ, SGLT1, GLUT2) and in the liver (glycogenolysis and/or gluconeogenesis key enzymes (glucose-6-phosphatase (G6Pase) and phosphoenolpyruvate carboxykinase (PEPCK)) and pro-inflammatory cytokine expression (TNF-α and IL-1β)). BPS at 25, 50, and 100 μg/kg was administered to mice in water drink for 10 weeks. In the duodenum, BPS exposure reduces significantly mRNA expression of sodium glucose transporter 1 (SGLT1), glucose transporter 2 (GLUT2), apelin, and APJ mRNA. In the liver, BPS exposure increases the expression of G6Pase and PEPCK, but does not affect pro-inflammatory markers. These data suggest that alteration of apelinergic system and glucose transporters expression could contribute to a disruption of intestinal glucose absorption, and that BPS stimulates glycogenolysis and/or gluconeogenesis in the liver. Collectively, we reveal that BPS heightens the risk of metabolic syndrome.
KeywordsBisphenol S Health hazards Glucose transporters (SGLT1/GLUT2) Apelinergic system Intestinal glucose absorption
This work was supported by the Tunisian Ministry of Higher Education and Scientific Research. We are grateful to Institut Français de Tunisie (IFT SSHN2015) for financial support. We thank particularly Dr Jalloul Bouajila from Faculty of Pharmacy of Toulouse (France) for technical assistance.
Compliance with ethical standards
Animals were treated in the respect of ethic and deontology, and all the procedure was accorded with Guidelines for Ethical Conduct in the Care and Use of Animals.
Conflict of interest
The authors declare that there are no conflicts of interest.
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