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Environmental Science and Pollution Research

, Volume 26, Issue 14, pp 13833–13838 | Cite as

The research of synthesis and bioactivity of the novel indanedione anticoagulant rodenticides

  • Feng Chen
  • Tong ZhangEmail author
  • Chuang Qu
  • Jinming Wang
  • Hua Su
  • Ruofan Shi
  • Xingyu Zhu
Sustainable Environmental Management
  • 339 Downloads

Abstract

Three new anticoagulant rodenticides R1, R2, and R3 were designed. The containing fluorine acute toxicity groups was added to 1,3-indandione derivative. Analysis method of synthesized anticoagulant rodenticides were IR, 1H NMR. Acute bioactivity of the new rodenticides was evaluated, including the coefficient of absorb food and median lethal dose (LD50). Average coefficient of absorbed food for R1 was 0.54 and LD50 of R1 was 2.15 mg/kg. Average coefficient of absorbed food for R2 was 0.59 and the acute oral LD50 of R2 was 2.65 mg/kg. Average feeding coefficient of R3 was 0.68 and the acute oral LD50 of R3 was 3.12 mg/kg. Experiments showed that rat’s death peak was at about 72 h and rodenticides had good characteristics of acute medicine. The LD50 of three new fluoride anticoagulant rodenticides showed that they had good palatability for big white rats, and they had a strong poison effect on rodent. The result of all experiments proved that the synthesis of 1,3-indan diketone used as parent compound of new anticoagulant rodenticides could replace the current 4-hydroxyl coumarin as parent compound of the second-generation anticoagulant rodenticides. 1,3-Indan diketone would be widely used as parent compound of anticoagulant rodenticides.

Keywords

Anticoagulant rodenticide Fluorouracil chloride Phenylacetone LD50 Feeding coefficient 1,1-Double phenyl acetone 1,3-Indandione 

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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2018

Authors and Affiliations

  • Feng Chen
    • 1
  • Tong Zhang
    • 1
    Email author
  • Chuang Qu
    • 1
  • Jinming Wang
    • 1
  • Hua Su
    • 1
  • Ruofan Shi
    • 1
  • Xingyu Zhu
    • 1
  1. 1.College of ScienceNortheastern UniversityShenyangPeople’s Republic of China

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