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Effect of vitamin A and vitamin C on attenuation of ivermectin-induced toxicity in male Wistar rats

Environmental Science and Pollution Research volume 25, pages 29408–29417 (2018)Cite this article

Abstract

An in vivo study was performed to assay the effects of ivermectin on adult male Wistar rats. Twenty-five male Wistar rats aged 6 to 8 weeks and weighing 150–250 g were divided into five groups of five animals each for the purpose of this study. The groups received ivermectin; a mixture of ivermectin and vitamin A; a mixture of ivermectin and vitamin C; and a mixture of ivermectin, vitamin A, and vitamin C, respectively. One group served as the control group and was treated with double-distilled water. The treatment was carried out once a week for 3 weeks. The results of the study revealed that the animals were less affected as detected by slight changes in the body weight, stress oxidative parameters, serum levels of liver enzymes, kidney function indexes, cell blood counts, and sperm analysis upon exposure to ivermectin. Nevertheless, the use of vitamins A and C might have a promising effect against oxidant-antioxidant imbalance. Although, the administration of free ivermectin has fewer reactions on mammals, use of the drug supplemented with antioxidants such as vitamins A and C moderates its effects.

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Funding

The study was funded by Vice-Chancellor for Research, Faculty of Veterinary Medicine of University of Tehran (No. 3674).

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Affiliations

  1. School of Veterinary Medicine, University of Tehran, Tehran, Iran

    Fatemeh Sadat Hosseini Omshi, Maliheh Abbasalipourkabir, Sedigheh Nabyan & Alireza Bashiri

  2. School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran

    Roghayeh Abbasalipourkabir

  3. School of Pharmacy, Hamadan University of Medical Sciences, Hamadan, Iran

    Abolfazl Ghafourikhosroshahi

Authors
  1. Fatemeh Sadat Hosseini Omshi
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  2. Roghayeh Abbasalipourkabir
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  3. Maliheh Abbasalipourkabir
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  4. Sedigheh Nabyan
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  5. Alireza Bashiri
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  6. Abolfazl Ghafourikhosroshahi
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Correspondence to Roghayeh Abbasalipourkabir.

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Responsible editor: Philippe Garrigues

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Hosseini Omshi, F.S., Abbasalipourkabir, R., Abbasalipourkabir, M. et al. Effect of vitamin A and vitamin C on attenuation of ivermectin-induced toxicity in male Wistar rats. Environ Sci Pollut Res 25, 29408–29417 (2018). https://doi.org/10.1007/s11356-018-2961-7

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  • DOI: https://doi.org/10.1007/s11356-018-2961-7

Keywords

  • Ivermectin
  • Rat
  • Vitamin A
  • Vitamin C