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Long non-coding RNA CASC15 promotes tongue squamous carcinoma progression through targeting miR-33a-5p

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Abstract

Long non-coding RNAs (lncRNAs) have gained a lot of attention because they participate in several human disorders, including tumors. This study determined the role of LncRNA CASC15 (cancer susceptibility candidate 15) in the development of tongue squamous cell carcinoma (TSCC). Here, we identified that CASC15 expression was upregulated in TSCC samples and cell lines. We showed that overexpression of CASC15 promoted cell proliferation, cycle, and migration in TSCC. In addition, we revealed that miR-33a-5p expression was downregulated in TSCC tissues and cell lines. Moreover, we showed that the expression of CASC15 was negatively related with miR-33a-5p expression in TSCC tissues. Ectopic expression of miR-33a-5p suppressed cell proliferation, cycle, and migration in TSCC. Elevated expression of CASC15 suppressed miR-33a-5p expression and promoted ZEB1 expression in SCC4 cell. Ectopic expression of CASC15 promoted TSCC cell proliferation, cycle, and migration through targeting miR-33a-5p. These results suggested that lncRNA CASC15 and miR-33a-5p might be exploited as new markers of TSCC and were potential treatment targets for TSCC patients.

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  1. Zhibin Zuo and Long Ma contributed equally to this work.

Authors and Affiliations

  1. Department of Periodontology, Jinan Stomatological Hospital, Jinan, Shandong, China

    Zhibin Zuo, Long Ma & Lande Xue

  2. Department of Endodontics, Jinan Stomatological Hospital, Jinan, Shandong, China

    Zuode Gong & Qibao Wang

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  1. Zhibin Zuo
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  2. Long Ma
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  3. Zuode Gong
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  4. Lande Xue
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  5. Qibao Wang
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Correspondence to Qibao Wang.

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Responsible editor: Philippe Garrigues

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Zuo, Z., Ma, L., Gong, Z. et al. Long non-coding RNA CASC15 promotes tongue squamous carcinoma progression through targeting miR-33a-5p. Environ Sci Pollut Res 25, 22205–22212 (2018). https://doi.org/10.1007/s11356-018-2300-z

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