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Environmental Science and Pollution Research

, Volume 24, Issue 30, pp 23498–23507 | Cite as

Urinary arsenic, cadmium, manganese, nickel, and vanadium levels of schoolchildren in the vicinity of the industrialised area of Asaluyeh, Iran

  • Raheleh Kafaei
  • Rahim Tahmasbi
  • Masomeh Ravanipour
  • Dariush Ranjbar Vakilabadi
  • Mehdi Ahmadi
  • Abdolmajid Omrani
  • Bahman Ramavandi
Research Article

Abstract

Asaluyeh is one of the most heavily industrialised areas in the world where gas, petrochemical, and many downstream industries are located. This study aims to survey the biomonitoring of four metals and one metalloid in children living in the vicinity of Asaluyeh area. To do this, we analysed the creatinine-adjusted urinary levels of arsenic (As), cadmium (Cd), vanadium (V), manganese (Mn), and nickel (Ni) in 184 elementary schoolchildren (99 boys and 85 girls) living in Asaluyeh and compared them with a reference population. The comparisons were done for two seasons (spring and fall). The results showed that in the case area (Asaluyeh), the levels of As, V, Mn, and Ni were significantly higher and that of Cd was not significantly higher than the reference city for both seasons. The mean concentration of metal(loid)s in Asaluyeh (case) and Sadabad (reference) area as μg g−1 creatinine was As 2.90 and 2.24, V 0.06 and 0.03, Mn 0.28 and 0.25, Ni 0.54 and 0.29, and Cd 0.31 and 0.28 in spring and As 3.08 and 2.28, V 0.07 and 0.03, Mn 0.30 and 0.26, Ni 0.91 and 0.30, and Cd 0.36 and 0.31 in the fall. Seasonal variations played a key role in determining urinary metal(loid) concentration, as we saw the significant level of As, Cd, V, and Ni in fall than in spring. With regard to the impact of gender on the absorption and accumulation of urinary metal(loid)s, boys showed higher levels of the studied elements, especially for As, than girls as outdoor activities are more popular among boys. Due to the values being lower than those reported in literature, more research is needed on various population groups and other exposure sources in order to judge whether living in the vicinity of the gas and petrochemical industries in Asaluyeh is a threat to nearby residents.

Keywords

Asaluyeh area Schoolchildren Environmental pollution Urinary metals and metalloid Gas and petrochemical industry Human biomonitoring 

Notes

Acknowledgements

The present paper was extracted from MSc. thesis of R. Kafaei, a student of Bushehr University of Medical Sciences (BPUMS); the financial support from BPUMS (Grant no. 1392-H-114) to conduct this work is appreciated. The kind collaboration of the schoolchildren’s parents and school staff of Asaluyeh and Sadabad, Iran, is gratefully acknowledged.

Compliance with ethical standards

Conflict of interests

The authors declare that they have no conflict of interests.

Statement of ethical approval

The study was conducted in accordance with the Ethical Principles for Medical Research Involving Human Subjects and was affirmed by Bushehr University of Medical Sciences (ethic code: IR.BPUMS.REC.1395.12).

Supplementary material

11356_2017_9981_MOESM1_ESM.docx (16 kb)
ESM 1 (DOCX 16 kb)

References

  1. Abdollahi S, Raoufi Z, Faghiri I, Savari A, Nikpour Y, Mansouri A (2013) Contamination levels and spatial distributions of heavy metals and PAHs in surface sediment of Imam Khomeini Port, Persian Gulf, Iran. Mar Pollut Bull 71:336–345CrossRefGoogle Scholar
  2. Aguilera I, Daponte A, Gil F, Hernández AF, Godoy P, Pla A, Ramos JL (2008) Biomonitoring of urinary metals in a population living in the vicinity of industrial sources: a comparison with the general population of Andalusia, Spain. Sci Total Environ 407:669–678CrossRefGoogle Scholar
  3. Aguilera I, Daponte A, Gil F, Hernández AF, Godoy P, Pla A, Ramos JL (2010) Urinary levels of arsenic and heavy metals in children and adolescents living in the industrialised area of Ria of Huelva (SW Spain). Environ Int 36:563–569CrossRefGoogle Scholar
  4. Akerstrom M, Barregard L, Lundh T, Sallsten G (2013) The relationship between cadmium in kidney and cadmium in urine and blood in an environmentally exposed population. Toxicol Appl Pharmacol 268:286–293CrossRefGoogle Scholar
  5. Alimonti A, Petrucci F, Krachler M, Bocca B, Caroli S (2000) Reference values for chromium, nickel and vanadium in urine of youngsters from the urban area of Rome. J Environ Monit 2:351–354CrossRefGoogle Scholar
  6. Al-Saleh I, Shinwari N, Mashhour A, Mohamed GED, Rabah A (2011) Heavy metals (lead, cadmium and mercury) in maternal, cord blood and placenta of healthy women. Int J Hyg Environ Health 214:79–101CrossRefGoogle Scholar
  7. Angerer J, Ewers U, Wilhelm M (2007) Human biomonitoring: state of the art. Int J Hyg Environ Health 210:201–228CrossRefGoogle Scholar
  8. Arrizabalaga JJ, Larrañaga N, Espada M, Amiano P, Bidaurrazaga J, Latorre K, Gorostiza E (2012) Changes in iodine nutrition status in schoolchildren from the Basque Country. Endocrinología y Nutrición (English Edition) 59:474–484CrossRefGoogle Scholar
  9. Banerjee TD, Middleton F, Faraone SV (2007) Environmental risk factors for attention-deficit hyperactivity disorder. Acta Paediatr 96:1269–1274CrossRefGoogle Scholar
  10. Becker K et al (2013) German health-related environmental monitoring: assessing time trends of the general population’s exposure to heavy metals. Int J Hyg Environ Health 216:250–254CrossRefGoogle Scholar
  11. Brand A, McLean KE, Henderson SB, Fournier M, Liu L, Kosatsky T, Smargiassi A (2016) Respiratory hospital admissions in young children living near metal smelters, pulp mills and oil refineries in two Canadian provinces. Environ Int 94:24–32CrossRefGoogle Scholar
  12. Černá M, Krsková A, Čejchanová M, Spěváčková V (2012) Human biomonitoring in the Czech Republic: an overview. Int J Hyg Environ Health 215:109–119CrossRefGoogle Scholar
  13. Chaumont A, Nickmilder M, Dumont X, Lundh T, Skerfving S, Bernard A (2012) Associations between proteins and heavy metals in urine at low environmental exposures: evidence of reverse causality. Toxicol Lett 210:345–352CrossRefGoogle Scholar
  14. Davoudi M, Rahimpour M, Jokar S, Nikbakht F, Abbasfard H (2013) The major sources of gas flaring and air contamination in the natural gas processing plants: a case study. J Nat Gas Sci Eng 13:7–19CrossRefGoogle Scholar
  15. de Burbure C et al (2006) Renal and neurologic effects of cadmium, lead, mercury, and arsenic in children: evidence of early effects and multiple interactions at environmental exposure levels. Environ Health Perspect 114:584–590CrossRefGoogle Scholar
  16. de Souza GC et al (2015) Lead concentrations in whole blood, serum, saliva and house dust in samples collected at two time points (12 months apart) in Santo Amaro, BA, Brazil. Environ Res 142:337–344CrossRefGoogle Scholar
  17. Esteban M, Castaño A (2009) Non-invasive matrices in human biomonitoring: a review. Environ Int 35:438–449CrossRefGoogle Scholar
  18. Fay RM, Mumtaz MM (1996) Development of a priority list of chemical mixtures occurring at 1188 hazardous waste sites, using the hazdat database. Food Chem Toxicol 34:1163–1165CrossRefGoogle Scholar
  19. Fortoul T et al (2014) Overview of environmental and occupational vanadium exposure and associated health outcomes: an article based on a presentation at the 8th International Symposium on Vanadium Chemistry, Biological Chemistry, and Toxicology, Washington DC, August 15–18, 2012. J Immunotoxicol 11:13–18CrossRefGoogle Scholar
  20. Gdula-Argasińska J, Appleton J, Sawicka-Kapusta K, Spence B (2004) Further investigation of the heavy metal content of the teeth of the bank vole as an exposure indicator of environmental pollution in Poland. Environ Pollut 131:71–79CrossRefGoogle Scholar
  21. Gil F, Hernández AF, Márquez C, Femia P, Olmedo P, López-Guarnido O, Pla A (2011) Biomonitorization of cadmium, chromium, manganese, nickel and lead in whole blood, urine, axillary hair and saliva in an occupationally exposed population. Sci Total Environ 409:1172–1180CrossRefGoogle Scholar
  22. Gopalan HN (2003) Environmental health in developing countries: an overview of the problems and capacities. Environ Health Perspect 111:A446CrossRefGoogle Scholar
  23. Gumpu MB, Sethuraman S, Krishnan UM, Rayappan JBB (2015) A review on detection of heavy metal ions in water—an electrochemical approach. Sensors Actuators B Chem 213:515–533CrossRefGoogle Scholar
  24. Hansen ÅM, Garde AH, Skovgaard LT, Christensen JM (2001) Seasonal and biological variation of urinary epinephrine, norepinephrine, and cortisol in healthy women. Clin Chim Acta 309:25–35CrossRefGoogle Scholar
  25. Heitland P, Köster HD (2006) Biomonitoring of 30 trace elements in urine of children and adults by ICP-MS. Clin Chim Acta 365:310–318CrossRefGoogle Scholar
  26. Hu H, Rabinowitz M, Smith D (1998) Bone lead as a biological marker in epidemiologic studies of chronic toxicity: conceptual paradigms. Environ Health Perspect 106:1CrossRefGoogle Scholar
  27. Hussein Were F, Njue W, Murungi J, Wanjau R (2008) Use of human nails as bio-indicators of heavy metals environmental exposure among school age children in Kenya. Sci Total Environ 393:376–384CrossRefGoogle Scholar
  28. Imtiaz M et al (2015) Vanadium, recent advancements and research prospects: a review. Environ Int 80:79–88CrossRefGoogle Scholar
  29. Jiang C-B, Yeh C-Y, Lee H-C, Chen M-J, Hung F-Y, Fang S-S, Chien L-C (2010) Mercury concentration in meconium and risk assessment of fish consumption among pregnant women in Taiwan. Sci Total Environ 408:518–523CrossRefGoogle Scholar
  30. Kafaei R et al (2017) Data on metals biomonitoring in the body of schoolchildren in the vicinity of a heavily industrialized site. Data Brief 12:405–408CrossRefGoogle Scholar
  31. Kampeerawipakorn O et al (2017) Health risk evaluation in a population exposed to chemical releases from a petrochemical complex in Thailand. Environ Res 152:207–213CrossRefGoogle Scholar
  32. Kim K-H, Shon Z-H, Mauulida PT, Song S-K (2014) Long-term monitoring of airborne nickel (Ni) pollution in association with some potential source processes in the urban environment. Chemosphere 111:312–319CrossRefGoogle Scholar
  33. Kim J et al (2015) Wearable temporary tattoo sensor for real-time trace metal monitoring in human sweat. Electrochem Commun 51:41–45CrossRefGoogle Scholar
  34. Kordas K, Queirolo EI, Ettinger AS, Wright RO, Stoltzfus RJ (2010) Prevalence and predictors of exposure to multiple metals in preschool children from Montevideo, Uruguay. Sci Total Environ 408:4488–4494CrossRefGoogle Scholar
  35. Kossowska B, Dudka I, Gancarz R, Antonowicz-Juchniewicz J (2013) Application of classic epidemiological studies and proteomics in research of occupational and environmental exposure to lead, cadmium and arsenic. Int J Hyg Environ Health 216:1–7CrossRefGoogle Scholar
  36. Kresovich JK, Argos M, Turyk ME (2015) Associations of lead and cadmium with sex hormones in adult males. Environ Res 142:25–33CrossRefGoogle Scholar
  37. Laidlaw MA, Mielke HW, Filippelli GM, Johnson DL, Gonzales CR (2005) Seasonality and children’s blood lead levels: developing a predictive model using climatic variables and blood lead data from Indianapolis, Indiana, Syracuse, New York, and New Orleans, Louisiana (USA). Environ Health Perspect 113:793–800CrossRefGoogle Scholar
  38. Lee JW et al (2012) Korea national survey for environmental pollutants in the human body 2008: heavy metals in the blood or urine of the Korean population. Int J Hyg Environ Health 215:449–457CrossRefGoogle Scholar
  39. Li Z, Sandau CD, Romanoff LC, Caudill SP, Sjodin A, Needham LL, Patterson DG (2008) Concentration and profile of 22 urinary polycyclic aromatic hydrocarbon metabolites in the US population. Environ Res 107:320–331CrossRefGoogle Scholar
  40. Liu K-S et al (2013) Breast milk lead and cadmium levels in suburban areas of Nanjing, China. Chin Med Sci J 28:7–15CrossRefGoogle Scholar
  41. MacGregor JA, Du H (2014) Re: vanadium exposure-induced neurobehavioral alterations among Chinese workers Li et al. (2013). Neurotoxicology 44:369CrossRefGoogle Scholar
  42. Md Khudzari J, Wagiran H, Hossain I, Ibrahim N (2013) Screening heavy metals levels in hair of sanitation workers by X-ray fluorescence analysis. J Environ Radioact 115:1–5CrossRefGoogle Scholar
  43. Molina-Villalba I, Lacasaña M, Rodríguez-Barranco M, Hernández AF, Gonzalez-Alzaga B, Aguilar-Garduño C, Gil F (2015) Biomonitoring of arsenic, cadmium, lead, manganese and mercury in urine and hair of children living near mining and industrial areas. Chemosphere 124:83–91CrossRefGoogle Scholar
  44. Morton J, Tan E, Leese E, Cocker J (2014) Determination of 61 elements in urine samples collected from a non-occupationally exposed UK adult population. Toxicol Lett 231:179–193CrossRefGoogle Scholar
  45. Nadal M, Schuhmacher M, Domingo JL (2004) Metal pollution of soils and vegetation in an area with petrochemical industry. Sci Total Environ 321:59–69CrossRefGoogle Scholar
  46. Nadal M, Schuhmacher M, Domingo JL (2007) Levels of metals, PCBs, PCNs and PAHs in soils of a highly industrialized chemical/petrochemical area: temporal trend. Chemosphere 66:267–276CrossRefGoogle Scholar
  47. Nisse C, Tagne-Fotso R, Howsam M, Richeval C, Labat L, Leroyer A (2016) Blood and urinary levels of metals and metalloids in the general adult population of Northern France: the IMEPOGE study, 2008–2010. Int J Hyg Environ Health.  https://doi.org/10.1016/j.ijheh.2016.09.020
  48. Norouzi S, Khademi H, Faz Cano A, Acosta JA (2015) Using plane tree leaves for biomonitoring of dust borne heavy metals: a case study from Isfahan, Central Iran. Ecol Indic 57:64–73CrossRefGoogle Scholar
  49. Norouzi S, Khademi H, Ayoubi S, Faz Cano A, Acosta JA (2017) Seasonal and spatial variations in dust deposition rate and concentrations of dust-borne heavy metals, a case study from Isfahan, central Iran. Atmos Pollut Res 8:686–699CrossRefGoogle Scholar
  50. Olawoyin R, Heidrich B, Oyewole S, Okareh OT, McGlothlin CW (2014) Chemometric analysis of ecological toxicants in petrochemical and industrial environments. Chemosphere 112:114–119CrossRefGoogle Scholar
  51. Protano C, Astolfi ML, Canepari S, Vitali M (2016) Urinary levels of trace elements among primary school-aged children from Italy: the contribution of smoking habits of family members. Sci Total Environ 557:378–385CrossRefGoogle Scholar
  52. Rangel-Méndez JA, Arcega-Cabrera FE, Fargher LF, Moo-Puc RE (2016) Mercury levels assessment and its relationship with oxidative stress biomarkers in children from three localities in Yucatan, Mexico. Sci Total Environ 543:187–196CrossRefGoogle Scholar
  53. Roca M, Sánchez A, Pérez R, Pardo O, Yusà V (2016) Biomonitoring of 20 elements in urine of children. Levels and predictors of exposure. Chemosphere 144:1698–1705CrossRefGoogle Scholar
  54. Saidi M, Siavashi F, Rahimpour M (2014) Application of solid oxide fuel cell for flare gas recovery as a new approach; a case study for Asalouyeh gas processing plant, Iran. J Nat Gas Sci Eng 17:13–25CrossRefGoogle Scholar
  55. Soltanieh M, Zohrabian A, Gholipour MJ, Kalnay E (2016) A review of global gas flaring and venting and impact on the environment: case study of Iran. Int J Greenhouse Gas Control 49:488–509CrossRefGoogle Scholar
  56. Soriano A, Pallarés S, Pardo F, Vicente AB, Sanfeliu T, Bech J (2012) Deposition of heavy metals from particulate settleable matter in soils of an industrialised area. J Geochem Explor 113:36–44CrossRefGoogle Scholar
  57. Spěváčková V, Čejchanová M, Černá M, Spěváček V, Šmíd J, Beneš B (2002) Population-based biomonitoring in the Czech Republic: urinary arsenic. J Environ Monit 4:796–798CrossRefGoogle Scholar
  58. Sughis M, Nawrot TS, Riaz A, Ikram-Dar U, Mahmood A, Haufroid V, Nemery B (2014) Metal exposure in schoolchildren and working children. A urinary biomonitoring study from Lahore, Pakistan. Int J Hyg Environ Health 217:669–677CrossRefGoogle Scholar
  59. Tellez-Plaza M, Navas-Acien A, Crainiceanu CM, Sharrett AR, Guallar E (2010) Cadmium and peripheral arterial disease: gender differences in the 1999–2004 US National Health and Nutrition Examination Survey. Am J Epidemiol 172:671–681CrossRefGoogle Scholar
  60. Varrica D et al (2014) Metals and metalloids in hair samples of children living near the abandoned mine sites of Sulcis-Inglesiente (Sardinia, Italy). Environ Res 134:366–374CrossRefGoogle Scholar
  61. Wilhelm M et al (2013) Levels and predictors of urinary nickel concentrations of children in Germany: results from the German Environmental Survey on children (GerES IV). Int J Hyg Environ Health 216:163–169CrossRefGoogle Scholar
  62. Xu D-X, Shen H-M, Zhu Q-X, Chua L, Wang Q-N, Chia S-E, Ong C-N (2003) The associations among semen quality, oxidative DNA damage in human spermatozoa and concentrations of cadmium, lead and selenium in seminal plasma. Mutat Res Genet Toxicol Environ Mutagen 534:155–163CrossRefGoogle Scholar
  63. Yuan T, Pien W, Chan C (2013) Urinary heavy metal levels of residents in the vicinity of a petrochemical complex in Taiwan. Published by EDP sciences. http://www.e3s-Conferences.Org. Accessed 2103
  64. Zhang X, Cui X, Lin C, Ma J, Liu X, Zhu Y (2016) Reference levels and relationships of nine elements in first-spot morning urine and 24-h urine from 210 Chinese children. Int J Hyg Environ Health.  https://doi.org/10.1016/j.ijheh.2016.10.013

Copyright information

© Springer-Verlag GmbH Germany 2017

Authors and Affiliations

  1. 1.Department of Environmental Health Engineering, Faculty of Health and NutritionBushehr University of Medical SciencesBushehrIran
  2. 2.Department of Biostatistics, Faculty of Health and NutritionBushehr University of Medical SciencesBushehrIran
  3. 3.Environmental Technologies Research CenterAhvaz Jundishapur University of Medical SciencesAhvazIran
  4. 4.Department of Environmental Health EngineeringAhvaz Jundishapur University of Medical SciencesAhvazIran
  5. 5.Department of Pediatrics, Faculty of MedicineBushehr University of Medical SciencesBushehrIran

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