Comparison of normal and dusty day impacts on fractional exhaled nitric oxide and lung function in healthy children in Ahvaz, Iran

Abstract

Children are the vulnerable group at risk of adverse health effects related to air pollution due to dust storm in Ahvaz. The purpose of this study was to compare the values of fractional exhaled nitric oxide (FENO) and lung functions as parameters of adverse health effects of particulate matter (PM) in dusty and normal (non-dusty) days in elementary schoolchildren. The study was conducted among elementary school students in Ahvaz. The healthy elementary schoolchildren (N = 105) were selected from different districts for FENO and lung function sampling during the dusty and normal days. The values of PM10 and PM2.5 during dusty days were higher than during normal days. Mean values of FENO during the normal and dusty days were 14.23 and 20.3 ppb, respectively, and the difference between these values was statistically significant (p < 0.05). Lung function results showed a statistically significant difference between the mean values of forced vital capacity during the dusty and normal days (p < 0.05). The results revealed a significant difference both in the values of inflammatory biomarker and in the lung function tests in dusty and normal days. Based on our results, fractional exhaled nitric oxide could be a useful short-term biomarker of particulate pollution effect coupled with spirometry.

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References

  1. Ackermann-Liebrich U et al (1997) Lung function and long term exposure to air pollutants in Switzerland. Study on Air Pollution and Lung Diseases in Adults (SAPALDIA) Team. Am J Respir Crit Care Med 155:122–129

    CAS  Article  Google Scholar 

  2. Adamkiewicz G, Ebelt S, Syring M, Slater J, Speizer FE, Schwartz J, Suh H, Gold DR (2004) Association between air pollution exposure and exhaled nitric oxide in an elderly population. Thorax 59:204–209

    CAS  Article  Google Scholar 

  3. Adams MD, Kanaroglou PS (2016) Mapping real-time air pollution health risk for environmental management: combining mobile and stationary air pollution monitoring with neural network models. J Environ Manag 168:133–141

    CAS  Article  Google Scholar 

  4. Atkinson RW, Anderson HR, Sunyer J, Ayres J, Baccini M, Vonk JM, Boumghar A, Forastiere F, Forsberg B, Touloumi G, Schwartz J, Katsouyanni K (2001) Acute effects of particulate air pollution on respiratory admissions: results from APHEA 2 project. Air pollution and health: a European approach. Am J Respir Crit Care Med 164:1860–1866

    CAS  Article  Google Scholar 

  5. Braniš M, Řezáčová P, Domasová M (2005) The effect of outdoor air and indoor human activity on mass concentrations of PM 10, PM 2.5, and PM 1 in a classroom. Environ Res 99:143–149

    Article  Google Scholar 

  6. Brunekreef B, Holgate ST (2002) Air pollution and health. Lancet 360:1233–1242

    CAS  Article  Google Scholar 

  7. Dales R, Wheeler A, Mahmud M, Frescura AM, Smith-Doiron M, Nethery E, Liu L (2008) The influence of living near roadways on spirometry and exhaled nitric oxide in elementary schoolchildren. Environ Health Persp 116:1423

    CAS  Article  Google Scholar 

  8. Delfino RJ, Quintana PJ, Floro J, Gastanaga VM, Samimi BS, Kleinman MT, Liu LJ, Bufalino C, Wu CF, McLaren CE (2004) Association of FEV1 in asthmatic children with personal and microenvironmental exposure to airborne particulate matter. Environ Health Perspect 112:932–941

    CAS  Article  Google Scholar 

  9. Delfino RJ, Norbert S, Dan G, Thomas T, Sioutas C, Fung K, Steven CG, Kleinman MT (2006) Personal and ambient air pollution is associated with increased exhaled nitric oxide in children with asthma. Environ Health Perspect 114:1736–1743

    CAS  Google Scholar 

  10. Delfino RJ, Staimer N, Tjoa T, Gillen D, Kleinman MT, Sioutas C, Cooper D (2008) Personal and ambient air pollution exposures and lung function decrements in children with asthma. Environ Health Perspect 116:550–558

    Article  Google Scholar 

  11. Dianat M, Radmanesh E, Badavi M, Goudarzi G, Mard SA (2016a) The effects of PM10 on electrocardiogram parameters, blood pressure and oxidative stress in healthy rats: the protective effects of vanillic acid. Environ Sci Pollut Res 23:19551–19560

    CAS  Article  Google Scholar 

  12. Dianat M, Radmanesh E, Badavi M, Mard SA, Goudarzi G (2016b) Disturbance effects of PM10 on iNOS and eNOS mRNA expression levels and antioxidant activity induced by ischemia–reperfusion injury in isolated rat heart: protective role of vanillic acid. Environ Sci Pollut Res 23:5154–5165

    CAS  Article  Google Scholar 

  13. Dobaradaran S, Geravandi S, Goudarzi G, Idani E, Salmanzadeh S, Soltani F, Yari AR, Mohammadi MJ (2016) Determination of cardiovascular and respiratory diseases caused by PM10 exposure in Bushehr, 2013. Journal of Mazandaran University of Medical Sciences 26:42–52

    Google Scholar 

  14. Dockery DW, Ware JH, Ferris BG, Speizer FE, Cook NR, Herman SM (1982) Change in pulmonary function in children associated with air pollution episodes. Journal of the Air Pollution Control Association 32:937–942

    CAS  Article  Google Scholar 

  15. Dweik RA, Boggs PB, Erzurum SC, Irvin CG, Leigh MW, Lundberg JO, Olin AC, Plummer AL, Taylor DR (2011) An official ATS clinical practice guideline: interpretation of exhaled nitric oxide levels (FENO) for clinical applications. Am J Respir Crit Care Med 184:602–615

    CAS  Article  Google Scholar 

  16. Epton MJ, Dawson RD, Brooks WM, Kingham S, Aberkane T, Cavanagh JA, Frampton CM, Hewitt T, Cook JM, McLeod S, McCartin F, Trought K, Brown L (2008) The effect of ambient air pollution on respiratory health of school children: a panel study. Environ Health 7:16

    Article  Google Scholar 

  17. Fazlzadeh M, Rostami R, Hazrati S, Rastgu A (2015) Concentrations of carbon monoxide in indoor and outdoor air of Ghalyun cafes. Atmospheric Pollution Research 6:550–555

    CAS  Article  Google Scholar 

  18. Fischer PH, Steerenberg PA, Snelder JD, van Loveren H, van Amsterdam JG (2002) Association between exhaled nitric oxide, ambient air pollution and respiratory health in school children. Int Arch Occup Environ Health 75:348–353

    CAS  Article  Google Scholar 

  19. Gauderman WJ, Avol E, Gilliland F, Vora H, Thomas D, Berhane K, McConnell R, Kuenzli N, Lurmann F, Rappaport E, Margolis H, Bates D, Peters J (2004) The effect of air pollution on lung development from 10 to 18 years of age. N Engl J Med 351:1057–1067

    CAS  Article  Google Scholar 

  20. Ghio AJ, Kim C, Devlin RB (2000) Concentrated ambient air particles induce mild pulmonary inflammation in healthy human volunteers. Am J Respir Crit Care Med 162:981–988

    CAS  Article  Google Scholar 

  21. Goudarzi G, Shirmardi M, Khodarahmi F, Hashemi-Shahraki A, Alavi N, Ankali KA, Babaei AA, Soleimani Z, Marzouni MB (2014) Particulate matter and bacteria characteristics of the Middle East Dust (MED) storms over Ahvaz, Iran. Aerobiologia 30:345–356

    Article  Google Scholar 

  22. Goudarzi G, Geravandi S, Foruozandeh H, Babaei AA, Alavi N, Niri MV, Khodayar MJ, Salmanzadeh S, Mohammadi MJ (2015a) Cardiovascular and respiratory mortality attributed to ground-level ozone in Ahvaz, Iran. Environ Monit Assess 187:487

    Article  Google Scholar 

  23. Goudarzi G, Geravandi S, Mohammadi MJ, Salmanzadeh S, Vosoughi M, Sahebalzamani M (2015b) The relationship between air pollution exposure and chronic obstructive pulmonary disease in Ahvaz, Iran. 2015, 3

  24. Goudarzi G, Geravandi S, Idani E, Hosseini SA, Baneshi MM, Yari AR, Vosoughi M, Dobaradaran S, Shirali S, Marzooni MB, Ghomeishi A, Alavi N, Alavi SS, Mohammadi MJ (2016) An evaluation of hospital admission respiratory disease attributed to sulfur dioxide ambient concentration in Ahvaz from 2011 through 2013. Environ Sci Pollut Res 23:22001–22007

    CAS  Article  Google Scholar 

  25. Greenwald R, Sarnat SE, Raysoni AU, Li W-W, Johnson BA, Stock TH, Holguin F, Sosa T, Sarnat JA (2013) Associations between source-indicative pollution metrics and increases in pulmonary inflammation and reduced lung function in a panel of asthmatic children. Air Quality, Atmosphere & Health 6:487–499

    Article  Google Scholar 

  26. Hashemzadeh B, Idani E, Goudarzi G, Ankali KA, Sakhvidi MJZ, Akbar Babaei A, Hashemzadeh H, Vosoughi M, Mohammadi MJ, Neisi A (2017) Effects of PM2.5 and NO2 on the 8-isoprostane and lung function indices of FVC and FEV1 in students of Ahvaz city, Iran. Saudi Journal of Biological Sciences

  27. Hazrati S, Rostami R, Fazlzadeh M (2015) BTEX in indoor air of waterpipe cafés: levels and factors influencing their concentrations. Sci Total Environ 524–525:347–353

    Article  Google Scholar 

  28. Heidari-Farsani M, Shirmardi M, Goudarzi G, Alavi-Bakhtiarivand N, Ahmadi-Ankali K, Zallaghi E, Naeimabadi A, Hashemzadeh B (2014) The evaluation of heavy metals concentration related to PM10 in ambient air of Ahvaz city, Iran. 2014, 1

  29. Hoffmann C, Funk R, Li Y, Sommer M (2008) Effect of grazing on wind driven carbon and nitrogen ratios in the grasslands of Inner Mongolia. Catena 75:182–190

    CAS  Article  Google Scholar 

  30. Jansen KL, Larson TV, Koenig JQ, Mar TF, Fields C, Stewart J, Lippmann M (2005) Associations between health effects and particulate matter and black carbon in subjects with respiratory disease. Environ Health Perspect 113:1741–1746

    CAS  Article  Google Scholar 

  31. Li N, Hao M, Phalen RF, Hinds WC, Nel AE (2003) Particulate air pollutants and asthma. A paradigm for the role of oxidative stress in PM-induced adverse health effects. Clin Immunol 109:250–265

    CAS  Article  Google Scholar 

  32. Maleki H, Sorooshian A, Goudarzi G, Nikfal A, Baneshi MM (2016) Temporal profile of PM10 and associated health effects in one of the most polluted cities of the world (Ahvaz, Iran) between 2009 and 2014. Aeolian Res 22:135–140

    Article  Google Scholar 

  33. Meo SA, Alsaaran ZF, Alshehri MK (2014) Effect of exposure to cement dust on fractional exhaled nitric oxide (FeNO) in non-smoking cement mill workers. Eur Rev Med Pharmacol Sci 18:1458–1464

    CAS  Google Scholar 

  34. Naimabadi A, Ghadiri A, Idani E, Babaei AA, Alavi N, Shirmardi M, Khodadadi A, Marzouni MB, Ankali KA, Rouhizadeh A, Goudarzi G (2016) Chemical composition of PM10 and its in vitro toxicological impacts on lung cells during the Middle Eastern Dust (MED) storms in Ahvaz, Iran. Environ Pollut 211:316–324

    CAS  Article  Google Scholar 

  35. Neisi A, Goudarzi G, Akbar Babaei A, Vosoughi M, Hashemzadeh H, Naimabadi A, Mohammadi MJ, Hashemzadeh B (2016) Study of heavy metal levels in indoor dust and their health risk assessment in children of Ahvaz city, Iran. Toxin Rev 35:16–23

    Article  Google Scholar 

  36. Nel AE, Diaz-Sanchez D, Li N (2001) The role of particulate pollutants in pulmonary inflammation and asthma: evidence for the involvement of organic chemicals and oxidative stress. Curr Opin Pulm Med 7:20–26

    CAS  Article  Google Scholar 

  37. Peng C, Luttmann-Gibson H, Zanobetti A, Cohen A, De Souza C, Coull BA, Horton ES, Schwartz J, Koutrakis P, Gold DR (2016) Air pollution influences on exhaled nitric oxide among people with type ii diabetes. Air Qual Atmos Health 9:265–273

    CAS  Article  Google Scholar 

  38. Pope CA 3rd, Dockery DW (1992) Acute health effects of PM10 pollution on symptomatic and asymptomatic children. Am Rev Respir Dis 145:1123–1128

    Article  Google Scholar 

  39. Rusconi F, Catelan D, Accetta G, Peluso M, Pistelli R, Barbone F, Di Felice E, Munnia A, Murgia P, Paladini L, Serci A, Biggeri A (2011) Asthma symptoms, lung function, and markers of oxidative stress and inflammation in children exposed to oil refinery pollution. J Asthma 48:84–90

    CAS  Article  Google Scholar 

  40. Shahsavani A, Naddafi K, Jaafarzadeh Haghighifard N, Mesdaghinia A, Yunesian M, Nabizadeh R, Arhami M, Yarahmadi M, Sowlat MH, Ghani M, Jonidi Jafari A, Alimohamadi M, Motevalian SA, Soleimani Z (2012a) Characterization of ionic composition of TSP and PM10 during the Middle Eastern Dust (MED) storms in Ahvaz, Iran. Environ Monit Assess 184:6683–6692

    CAS  Article  Google Scholar 

  41. Shahsavani A, Naddafi K, Jafarzade Haghighifard N, Mesdaghinia A, Yunesian M, Nabizadeh R, Arahami M, Sowlat MH, Yarahmadi M, Saki H, Alimohamadi M, Nazmara S, Motevalian SA, Goudarzi G (2012b) The evaluation of PM10, PM2.5, and PM1 concentrations during the Middle Eastern Dust (MED) events in Ahvaz, Iran, from april through september 2010. J Arid Environ 77:72–83

    Article  Google Scholar 

  42. Siddique S, Ray MR, Lahiri T (2011) Effects of air pollution on the respiratory health of children: a study in the capital city of India. Air Quality, Atmosphere & Health 4:95–102

    CAS  Article  Google Scholar 

  43. Soleimani Z, Goudarzi G, Naddafi K, Sadeghinejad B, Latifi SM, Parhizgari N, Alavi N, Babaei AA, Akhoond MR, Khaefi M, Rad HD, Mohammadi MJ, Shahsavani A (2013) Determination of culturable indoor airborne fungi during normal and dust event days in Ahvaz, Iran. Aerobiologia 29:279–290

    Article  Google Scholar 

  44. Soleimani Z, Goudarzi G, Sorooshian A, Marzouni MB, Maleki H (2016) Impact of Middle Eastern dust storms on indoor and outdoor composition of bioaerosol. Atmos Environ 138:135–143

    Article  Google Scholar 

  45. Spencer-Hwang R, Soret S, Knutsen S, Shavlik D, Ghamsary M, Beeson WL, Kim W, Montgomery S (2015) Respiratory health risks for children living near a major railyard. J Community Health 40:1015–1023

    Article  Google Scholar 

  46. WHO (2006) Air quality guidelines: global update 2005: particulate matter, ozone, nitrogen dioxide, and sulfur dioxide. World Health Organization

  47. Xie S, Li Qi YZ, Tang X (2005) Characteristics of air pollution in Beijing during sand-dust storm periods. Water, Air, & Soil Pollution: Focus 5:217–229

    CAS  Article  Google Scholar 

  48. Yang CY, Chen YS, Chiu HF, Goggins WB (2005) Effects of Asian dust storm events on daily stroke admissions in Taipei, Taiwan. Environ Res 99:79–84

    CAS  Article  Google Scholar 

  49. Yari AR, Goudarzi G, Geravandi S, Dobaradaran S, Yousefi F, Idani E, Jamshidi F, Shirali S, Khishdost M, Mohammadi MJ (2016) Study of ground-level ozone and its health risk assessment in residents in Ahvaz City, Iran during 2013. Toxin Rev 35:201–206

    CAS  Article  Google Scholar 

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Acknowledgments

This study was part of a funded Ph.D thesis of Mehdi Vosoughi, a student at Ahvaz Jundishapur University of Medical Sciences (AJUMS). AJUMS provided the financial support of this study (ETRC-9443). The authors also thank the National Oceanic Atmospheric Administration (NOAA) for providing a web-based HYSPLIT to allow us to do more workwise in this respect.

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Correspondence to Mehdi Vosoughi.

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This study was approved by the research ethics committee of Ahvaz Jundishapur University of Medical Sciences (IR.AJUMS.REC.1394.629).

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The authors declare that they have no conflicts of interest.

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Responsible editor: Philippe Garrigues

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Neisi, A., Vosoughi, M., Idani, E. et al. Comparison of normal and dusty day impacts on fractional exhaled nitric oxide and lung function in healthy children in Ahvaz, Iran. Environ Sci Pollut Res 24, 12360–12371 (2017). https://doi.org/10.1007/s11356-017-8853-4

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Keywords

  • Particulate matter
  • Fractional exhaled nitric oxide
  • Children
  • FVC, FEV1
  • Ahvaz