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Environmental Science and Pollution Research

, Volume 25, Issue 11, pp 10894–10903 | Cite as

Alteration of adaptive behaviors of progeny after maternal mobile phone exposure

  • Nicolas Petitdant
  • Anthony Lecomte
  • Franck Robidel
  • Christelle Gamez
  • Kelly Blazy
  • Anne-Sophie Villégier
Research Article

Abstract

Exposure of pregnant women to radiofrequency (RF) devices raises questions on their possible health consequences for their progeny. We examined the hazard threshold of gestational RF on the progeny’s glial homeostasis, sensory-motor gating, emotionality, and novelty seeking and tested whether maternal immune activation would increase RF toxicity. Pregnant dams were daily restrained with loop antennas adjoining the abdomen (fetus body specific absorption rates (SAR): 0, 0.7, or 2.6 W/kg) and received three lipopolysaccharide (LPS) intra-peritoneal injections (0 or 80 μg/kg). Scores in the prepulse startle inhibition, fear conditioning, open field, and elevated plus maze were assessed at adolescence and adulthood. Glial fibrillary acidic protein (GFAP) and interleukines-1β (ILs) were quantified. LPS induced a SAR-dependent reduction of the prepulse startle inhibition in adults. Activity in the open field was reduced at 2.6 W/kg at adolescence. GFAP and ILs, emotional memory, and anxiety-related behaviors were not modified. These data support the hypothesis that maternal immune activation increased the developmental RF exposure-induced long-term neurobiological impairments. These data support the fact that fetuses who receive combined environmental exposures with RF need special attention for protection.

Keywords

Mobile phone Radiofrequency Neurodevelopment Behavior Sensori-motor processing Locomotor activity 

Notes

Acknowledgements

This work was funded by the Agency for Food, Environmental, and Occupational Health and Safety INFLAREF-N°EST-2012/2/021 and Sby the French Ministry of Ecology Program 190.

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

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© Springer-Verlag GmbH Germany, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Toxicology UnitNational Institute for Environmental Protection and Industrial Risks (INERIS)Verneuil-en-HalatteFrance
  2. 2.PériTox-INERIS LaboratoryUMR-I 01 Jules Verne University of PicardyAmiensFrance
  3. 3.Unité de Toxicologie Expérimentale, Parc Technologique ALATAInstitut National de l’Environnement Industriel et des RisquesVerneuil-en-HalatteFrance

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