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Association between inflammation processes, DNA damage, and exposure to environmental pollutants

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Abstract

Environmental exposure to pollutants, especially polycyclic aromatic hydrocarbons (PAHs), could lead to carcinogenesis development. However, there is a gap on the mechanisms involved in this effect. Therefore, the aim of this study was to investigate the potential relationship between exposure to environmental air pollution and inflammation process in DNA damage in taxi drivers. This study included 45 taxi drivers and 40 controls; non-smokers composed both groups. Biological monitoring was performed through quantification of urinary 1-hydroxypyrene (1-OHP). ICAM-1 (CD54) expression, NTPDase activity, inflammatory cytokine (IL-1β, IL-6, IL-10, TNF-α and IFN-γ) levels, and comet and micronucleus assays were evaluated. The results demonstrated that 1-OHP levels, ICAM-1 expression, NTPDase activity, and DNA damage biomarkers (% tail DNA and micronucleus frequency) were increased in taxi drivers compared to the control group (p < 0.01). Moreover, significant associations were found between 1-OHP levels and ICAM-1 expression, % tail DNA, and micronucleus frequency (p < 0.05). Besides, pro-inflammatory cytokine levels were positively correlated to % tail DNA and micronucleus frequency (p < 0.001). Our findings suggest an important association between environmental exposure to air pollution with increase of ICAM-1 expression and NTPDase activity in taxi drivers. Additionally, the multiple regression linear-analysis demonstrated association between IL-6 and DNA damage. Thus, the present study has provided important evidence that, in addition to environmental exposure to air pollutants, the inflammation process may contribute to DNA damage.

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Acknowledgments

This work was supported by Fundação de Amparo à Pesquisa do Rio Grande do Sul (FAPERGS)/PPSUS-RS; Conselho Nacional de Pesquisa (CNPq) and Propesq, grant to S.C. Garcia. The authors are grateful for the careful English correction by J. Nardi. S.C. Garcia is a recipient of CNPq research fellowship.

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  1. Laboratory of Toxicology (LATOX), Department of Analysis, Faculty of Pharmacy, Federal University of Rio Grande do Sul, Avenida Ipiranga 2752, Santa Cecília, Porto Alegre, RS, CEP.: 90610-000, Brazil

    Anelise Barth, Natália Brucker, Angela M. Moro, Sabrina Nascimento, Gabriela Goethel, Caroline Souto, Rafael Fracasso, Elisa Sauer, Louise Altknecht, Bárbara da Costa, Marcelo D. Arbo & Solange Cristina Garcia

  2. Post-graduate Program in Pharmaceutical Sciences, Faculty of Pharmacy, Federal University of Rio Grande do Sul, Porto Alegre, RS, Brazil

    Sabrina Nascimento, Gabriela Goethel, Elisa Sauer, Camila B. Menezes, Tiana Tasca, Marcelo D. Arbo & Solange Cristina Garcia

  3. Department of Health Sciences, Lutheran University of Brazil, Santa Maria, RS, Brazil

    Marta Duarte

  4. Laboratory of Research in Parasitology, Department of Analysis, Faculty of Pharmacy, Federal University of Rio Grande do Sul, Porto Alegre, RS, Brazil

    Camila B. Menezes & Tiana Tasca

  5. Institute of Cardiology, University Cardiology Foundation, Porto Alegre, RS, Brazil

    Solange Cristina Garcia

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Barth, A., Brucker, N., Moro, A.M. et al. Association between inflammation processes, DNA damage, and exposure to environmental pollutants. Environ Sci Pollut Res 24, 353–362 (2017). https://doi.org/10.1007/s11356-016-7772-0

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