Environmental Science and Pollution Research

, Volume 23, Issue 19, pp 18988–19001

Glyphosate: environmental contamination, toxicity and potential risks to human health via food contamination

Review Article

DOI: 10.1007/s11356-016-7425-3

Cite this article as:
Bai, S.H. & Ogbourne, S.M. Environ Sci Pollut Res (2016) 23: 18988. doi:10.1007/s11356-016-7425-3


Glyphosate has been the most widely used herbicide during the past three decades. The US Environmental Protection Agency (EPA) classifies glyphosate as ‘practically non-toxic and not an irritant’ under the acute toxicity classification system. This classification is based primarily on toxicity data and due to its unique mode of action via a biochemical pathway that only exists in a small number of organisms that utilise the shikimic acid pathway to produce amino acids, most of which are green plants. This classification is supported by the majority of scientific literature on the toxic effects of glyphosate. However, in 2005, the Food and Agriculture Organisation (FAO) reported that glyphosate and its major metabolite, aminomethylphosphonic acid (AMPA), are of potential toxicological concern, mainly as a result of accumulation of residues in the food chain. The FAO further states that the dietary risk of glyphosate and AMPA is unlikely if the maximum daily intake of 1 mg kg−1 body weight (bw) is not exceeded. Research has now established that glyphosate can persist in the environment, and therefore, assessments of the health risks associated with glyphosate are more complicated than suggested by acute toxicity data that relate primarily to accidental high-rate exposure. We have used recent literature to assess the possible risks associated with the presence of glyphosate residues in food and the environment.


NOAEL Withholding period Contamination AMPA Herbicide Toxicity 

Supplementary material

11356_2016_7425_MOESM1_ESM.docx (227 kb)
Fig S1(DOCX 227 kb)
11356_2016_7425_MOESM2_ESM.docx (15 kb)
Table S1(DOCX 15 kb)

Funding information

Funder NameGrant NumberFunding Note

    Copyright information

    © Springer-Verlag Berlin Heidelberg 2016

    Authors and Affiliations

    1. 1.GeneCology Research Centre, Faculty of Science, Health, Education and EngineeringUniversity of the Sunshine CoastMaroochydore DCAustralia

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