Environmental Science and Pollution Research

, Volume 22, Issue 2, pp 1127–1132 | Cite as

In vivo toxicity of orally administrated silicon dioxide nanoparticles in healthy adult mice

  • Ramin Hassankhani
  • Mohammad Esmaeillou
  • Ali Asghar Tehrani
  • Keyvan Nasirzadeh
  • Fatemeh Khadir
  • Hamid MaadiEmail author
Research Article


The increasing use of silica nanoparticles (SiNPs) in various applications including industrial, agriculture, and medicine has raised concerns about their potential risks to human health. Various nanotoxicity researches have been done on the assessment of SiNPs’ toxic effects; however, a few in vivo investigations exist. In this investigation, an in vivo study was done in order to evaluate the oral toxicity of SiNPs. The biochemical levels of 19 different serum parameters were assessed. Moreover, the histopathological changes have been examined as well. We showed that SiNPs with diameters of 10–15 nm in size can cause significant changes in albumin, cholesterol, triglyceride, total protein, urea, HDL, and LDL as well as in alkaline phosphatase and aspartate aminotransferase activity. In addition, histopathological examinations demonstrated that SiNPs have toxic effects on various tissues including liver, kidney, lung, and testis.


SiO2 nanoparticles Oral gavage Liver Kidney Testis Lung Biochemical elements 


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Copyright information

© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  • Ramin Hassankhani
    • 1
  • Mohammad Esmaeillou
    • 2
  • Ali Asghar Tehrani
    • 3
  • Keyvan Nasirzadeh
    • 4
  • Fatemeh Khadir
    • 3
  • Hamid Maadi
    • 2
    Email author
  1. 1.Department of Science, Urmia BranchIslamic Azad UniversityUrmiaIran
  2. 2.Young Researchers and Elite Club, Urmia BranchIslamic Azad UniversityUrmiaIran
  3. 3.Department of Pathology, Faculty of Veterinary MedicineUrmia UniversityUrmiaIran
  4. 4.Industrial and Environmental Biotechnology DivisionNational Institute of Genetic Engineering and Biotechnology (NIGEB)TehranIran

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