DDT and its metabolites are linked to increased risk of type 2 diabetes among Saudi adults: a cross-sectional study
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Organochlorine (OC) pesticides have recently been associated with type 2 diabetes in several non-Asian general populations. As there is currently an epidemic of type 2 diabetes mellitus in Asia. The prevalence and incidence of diabetes is increasing rapidly worldwide including many Arab Gulf countries. According to a community-based national epidemiological health survey, the overall prevalence of diabetes mellitus in Saudi adults (age group of 30–50 years) is 23.7 %. A recent study by Al-Daghri et al. (BMC Med 9:76, 2011) reported that the prevalence of diabetes mellitus in the Kingdom of Saudi Arabia (KSA) is 31.6 %. We investigated the associations between OC pesticides and type 2 diabetes in Saudi Arabia using a simple, sensitive, rapid, and selective gas chromatography coupled with mass spectrometry (GC-MS) method that has been recently developed. A total of 280 Saudi adults (136 diabetes mellitus (DM) patients and 144 non-DM controls) were randomly selected from the Riyadh Cohort Study for inclusion. The diagnosis of diabetes was based on established diagnosis and medications taken. Blood dichlorodiphenyltrichloroethane (DDT) and its derivatives were quantified using GC-MS. Residues of DDT and its derivatives were analyzed in serum by means of gas chromatography with a mass spectrometry detector. Associations between DDT exposure and T2DM were analyzed by logistic regression. DDT and its derivatives and serum concentrations of DDT and its derivative DDE showed the strongest and most significant association to type 2 diabetes in both cross-sectional and prospective studies. Associations of DDT and its derivatives varied across different diabetes-related components of the metabolic syndrome. It positively and significantly associated with four of the five of these components especially elevated triacylglycerol, high fasting glucose, high blood pressure, and HOMA-IR but negatively and significantly with HDL. Possible biological mechanisms are discussed. This study confirms previous reports relating organochlorine pesticide (OCP) exposure to diabetes and suggests possible hormonal pathways deserving further exploration. The study will be one of the first to shed light on the associations of serum levels of total DDTs and DDT derivatives among the Saudi Arab ethnicity, and diabetes type 2 chronic noncommunicable diseases are highly prevalent.
KeywordsOCPs Environmental pollution Diabetes Biomarkers
Body mass index
Persistent organochlorine pollutants
Diabetes mellitus type 2
The authors gratefully acknowledge the National Plan for Sciences and Technology (NPST) for the financial support (10-ENE995-02). The authors thank Benjamin Vinodson for the statistical analysis of data.
Conflict of interest
The authors have no competing interests to declare.
Dr. Al-Daghri and Dr. Abd-Alrahman designed and initiated the current study and were responsible for collecting the samples and the interview data. Dr. Abd-Alrahman coordinated the current study and was responsible for the OCP analysis using GC-MS and for writing the draft version of the manuscript. Dr. Al-Daghri and Dr. Al-Othman were responsible for reviewing the draft version of the manuscript. All authors commented on and approved the final manuscript.
- Al-Nozha MM, Al-Maatouq MA, Al-Mazrou YY, Al-Harthi SS, Arafah MR, Khalil MZ, Khan NB, Al-Khadra A, Al-Marzouki K, Nouh MS, Abdullah M, Attas O, Al-Shahid MS, Al-Mobeireek A (2004) Diabetes mellitus in Saudi Arabia. Saudi Med J 25:1603–1610Google Scholar
- Codru N, Schymura MJ, Negoita S, Akwesasne Task Force on E, Rej R, Carpenter DO (2007) Diabetes in relation to serum levels of polychlorinated biphenyls and chlorinated pesticides in adult Native Americans. Environ Health Perspect 115:1442–1447Google Scholar
- Guilherme A, Virbasius JV, Puri V, Czech MP (2008) Adipocyte dysfunctions linking obesity to insulin resistance and type 2 diabetes. Nature reviews. Mol Cell Biol 9:367–377Google Scholar
- Kutz FW, Wood PH, Bottimore DP (1991) Organochlorine pesticides and polychlorinated biphenyls in human adipose tissue. Rev Environ Contam Toxicol 120:1–82Google Scholar
- Lee DH, Lind PM, Jacobs DR Jr, Salihovic S, van Bavel B, Lind L (2011) Polychlorinated biphenyls and organochlorine pesticides in plasma predict development of type 2 diabetes in the elderly: the prospective investigation of the vasculature in Uppsala Seniors (PIVUS) study. Diabetes Care 34:1778–1784CrossRefGoogle Scholar
- WHO (1979) DDT and its derivatives, Environmental Health CriteriaGoogle Scholar
- Wu H, Bertrand KA, Choi AL, Hu FB, Laden F, Grandjean P, Sun Q (2013) Persistent organic pollutants and type 2 diabetes: a prospective analysis in the nurses’ health study and meta-analysis. Environ Health Perspect 121:153–161Google Scholar