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Effect of ibuprofen exposure on blood, gill, liver, and brain on common carp (Cyprinus carpio) using oxidative stress biomarkers

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Abstract

Although trace concentrations of ibuprofen (IBP) have been detected in diverse water bodies, there is currently insufficient information on the potentially deleterious effects of this xenobiotic. The present study aimed to determine whether IBP induces oxidative stress in brain, liver, gill, and blood of the common carp Cyprinus carpio. To this end, the median lethal concentration at 96 h (96-h LC50) was determined and the lowest observed adverse effect level was established. Carp were exposed to the latter concentration (17.6 mg L−1) for 12, 24, 48, 72, and 96 h, and the following biomarkers were evaluated: lipid peroxidation (LPX) and activity of the antioxidant enzymes superoxide dismutase, catalase, and glutathione peroxidase. Results indicated that LPX and antioxidant enzymes’ activity increased significantly (p < 0.05) with respect to the control group in liver, gill, and blood, while no significant differences occurred in brain. In conclusion, IBP induced oxidative stress on C. carpio, the liver being the organ most affected by this damage.

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Acknowledgments

This study was made possible through support from the Consejo Nacional de Ciencia y Tecnología (CONACyT-Mexico, project 151665) and the Secretaria de Investigación y Estudios Avanzados de la UAEM (SIEA-UAEM, project UAEM 3415/2013CHT).

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  1. Laboratorio de Toxicología Ambiental, Facultad de Química, Universidad Autónoma del Estado de México, Paseo Colón intersección Paseo Tollocan s/n. Col. Residencial Colón, 50120, Toluca, Estado de México, México

    Hariz Islas-Flores, Leobardo Manuel Gómez-Oliván, Nadia Neri-Cruz & Octavio Dublán-García

  2. Laboratorio de Toxicología Acuática, Sección de Graduados e Investigación, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, Plan de Ayala y Carpio s/n, 11340, México, México

    Marcela Galar-Martínez & Sandra García-Medina

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  1. Hariz Islas-Flores
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  2. Leobardo Manuel Gómez-Oliván
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  3. Marcela Galar-Martínez
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  4. Sandra García-Medina
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Correspondence to Leobardo Manuel Gómez-Oliván.

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Islas-Flores, H., Gómez-Oliván, L.M., Galar-Martínez, M. et al. Effect of ibuprofen exposure on blood, gill, liver, and brain on common carp (Cyprinus carpio) using oxidative stress biomarkers. Environ Sci Pollut Res 21, 5157–5166 (2014). https://doi.org/10.1007/s11356-013-2477-0

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