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Environmental Science and Pollution Research

, Volume 21, Issue 4, pp 2479–2485 | Cite as

Urinary concentrations of trichlorophenols in the Korean adult population: results of the National Human Biomonitoring Survey 2009

  • Kisok KimEmail author
  • Hyejin Park
  • Jin Heon Lee
Research Article

Abstract

Trichlorophenols such as 2,4,5-trichlorophenol (2,4,5-TCP) and 2,4,6-trichlorophenol (2,4,6-TCP) are organochlorine compounds to which the general public can be exposed via contaminated food, water, and air. This study assessed exposure to 2,4,5-TCP and 2,4,6-TCP in Koreans age 18–69 years based on the Korean National Human Biomonitoring Survey conducted in 2009. Using data from 1,865 representative Koreans, we found that the geometric mean urinary concentrations of 2,4,5-TCP and 2,4,6-TCP were 83.4 pg/mL [95 % confidence interval (CI) = 78.6–88.6] and 0.39 ng/mL (95 % CI = 0.35–0.42), respectively. The creatinine-adjusted geometric mean 2,4,5-TCP and 2,4,6-TCP levels were 78.8 ng/g creatinine (95 % CI = 73.8–84.1) and 0.36 μg/g creatinine (95 % CI = 0.33–0.40), respectively. Of the Korean adult population, about 67.5 and 87.5 % had respective urine 2,4,5-TCP and 2,4,6-TCP concentrations >0.05 ng/mL (the limit of detection, LOD). Urine 2,4,5-TCP concentrations were significantly associated with age and place of residence, whereas urine 2,4,6-TCP concentrations were higher in rural residents. These findings suggest that most Koreans had detectable levels of 2,4,5-TCP and 2,4,6-TCP in their urine and that the body burden of 2,4,5-TCP and 2,4,6-TCP varied according to demographic and geographic factors.

Keywords

2,4,5-TCP 2,4,6-TCP Biomonitoring Human urine Demographic characteristics 

Notes

Acknowledgments

This research was supported by the Settlement Research Grant of Keimyung University in 2012.

Conflict of interest

The authors declare that they have no competing financial interests.

References

  1. ASTDR (1999) Toxicological profile for chlorophenols. Agency for Toxic Substances and Disease Registry, US Department of Health and Human ServiceGoogle Scholar
  2. Becker K, Schulz C, Kaus S, Seiwert M, Seifert B (2003) German environmental survey 1998 (GerES III): environmental pollutants in the urine of the German population. Int J Hyg Environ Health 206:15–24CrossRefGoogle Scholar
  3. Calafat AM, Ye X, Wong LY, Reidy JA, Needham LL (2008a) Exposure of the U.S. population to bisphenol A and 4-tertiary-octylphenol: 2003–2004. Environ Health Perspect 116:39–44CrossRefGoogle Scholar
  4. Calafat AM, Ye X, Wong LY, Reidy JA, Needham LL (2008b) Urinary concentrations of triclosan in the U.S. population: 2003–2004. Environ Health Perspect 116:303–307CrossRefGoogle Scholar
  5. CDC (2009) Fourth national report on human exposure to environmental chemicals, Centers for Disease Control and Prevention. Atlanta, USAGoogle Scholar
  6. Cole SR, Chu H, Nie L, Schisterman EF (2009) Estimating the odds ratio when exposure has a limit of detection. Int J Epidemiol 38:1674–1680CrossRefGoogle Scholar
  7. Draper WM (2001) Biological monitoring: exquisite research probes, risk assessment, and routine exposure measurement. Anal Chem 73:2745–2760CrossRefGoogle Scholar
  8. Hays SM, Aylward LL (2012) Interpreting human biomonitoring data in a public health risk context using biomonitoring equivalents. Int J Hyg Environ Health 215:145–148CrossRefGoogle Scholar
  9. He Y, Miao M, Herrinton LJ, Wu C, Yuan W, Zhou Z, Li DK (2009) Bisphenol A levels in blood and urine in a Chinese population and the personal factors affecting the levels. Environ Res 109:629–633CrossRefGoogle Scholar
  10. Hill RH Jr, Head SL, Baker S, Gregg M, Shealy DB, Bailey SL, Williams CC, Sampson EJ, Needham LL (1995) Pesticide residues in urine of adults living in the United States: reference range concentrations. Environ Res 71:99–108CrossRefGoogle Scholar
  11. Huff J (2012) Long-term toxicology and carcinogenicity of 2,4,6-trichlorophenol. Chemosphere 89:521–525CrossRefGoogle Scholar
  12. IARC (1999) IARC Monographs. International Agency for Research on Cancer, Lyon, FranceGoogle Scholar
  13. Kauppinen T, Kogevinas M, Johnson E et al (1993) Chemical exposure in manufacture of phenoxy herbicides and chlorophenols and in spraying of phenoxy herbicides. Am J Ind Med 23:903–920CrossRefGoogle Scholar
  14. Kim K, Park H, Yang W, Lee JH (2011) Urinary concentrations of bisphenol A and triclosan and associations with demographic factors in the Korean population. Environ Res 111:1280–1285CrossRefGoogle Scholar
  15. Mari M, Nadal M, Schuhmacher M, Domingo JL (2013) Body burden monitoring of dioxins and other organic substances in workers at a hazardous waste incinerator. Int J Hyg Environ Health. doi: 10.1016/j.ijheh.2013.01.003 Google Scholar
  16. National Toxicology Program (2011) 2,4,6-Trichlorophenol. Rep Carcinog 12:424–426Google Scholar
  17. Nichkova M, Marco MP (2006) Biomonitoring human exposure to organohalogenated substances by measuring urinary chlorophenols using a high-throughput screening (HTS) immunochemical method. Environ Sci Technol 40:2469–2477CrossRefGoogle Scholar
  18. Rawlings NC, Cook SJ, Waldbillig D (1998) Effects of the pesticides carbofuran, chlorpyrifos, dimethoate, lindane, triallate, trifluralin, 2,4-D, and pentachlorophenol on the metabolic endocrine and reproductive endocrine system in ewes. J Toxicol Environ Health A 54:21–36CrossRefGoogle Scholar
  19. Schmid K, Lederer P, Göen T, Schaller KH, Strebl H, Weber A, Angerer J, Lehnert G (1997) Internal exposure to hazardous substances of persons from various continents: investigations on exposure to different organochlorine compounds. Int Arch Occup Environ Health 69:399–406CrossRefGoogle Scholar
  20. Trasande L, Attina TM, Sathyanarayana S, Spanier AJ, Blustein J (2013) Race/ethnicity-specific associations of urinary phthalates with childhood body mass in a nationally representative sample. Environ Health Perspect 121:501–506Google Scholar
  21. Vandenberg LN, Chahoud I, Heindel JJ, Padmanabhan V, Paumgartten FJ, Schoenfelder G (2010) Urinary, circulating, and tissue biomonitoring studies indicate widespread exposure to bisphenol A. Environ Health Perspect 118:1055–1070CrossRefGoogle Scholar
  22. Ward MH, Colt JS, Metayer C, Gunier RB, Lubin J, Crouse V, Nishioka MG, Reynolds P, Buffler PA (2009) Residential exposure to polychlorinated biphenyls and organochlorine pesticides and risk of childhood leukemia. Environ Health Perspect 117:1007–1013Google Scholar
  23. World Health Organization (2000) The Asian-Pacific perspective: redefining obesity and its treatment, Manila, PhilippinesGoogle Scholar
  24. Xu X, Nembhard WN, Kan H, Kearney G, Zhang ZJ, Talbott EO (2011) Urinary trichlorophenol levels and increased risk of attention deficit hyperactivity disorder among US school-aged children. Occup Environ Med 68:557–561CrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2013

Authors and Affiliations

  1. 1.Department of PharmacyKeimyung UniversityDaeguRepublic of Korea
  2. 2.Department of International Medical ManagementCatholic University of DaeguKyungbukRepublic of Korea
  3. 3.Department of Environmental EducationKongju National UniversityChungnamRepublic of Korea

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