This study assessed the potential exposure risks for workers in the workplace exposed to airborne titanium dioxide nanoparticles (TiO2-NPs) and carbon black nanoparticles (CB-NPs). The risk management control strategies were also developed for the NP engineering workplace.
The method used in this study was based on the integrated multiple-path particle dosimetry model to estimate the cumulative dose of nanoparticles (NPs) in the human lung. The study then analyzed toxicological effects such as pulmonary cytotoxicity and inflammation and evaluated the health risk associated with exposure to NPs in the workplace. Risk control measures such as the use of ventilating systems and N95 respirator protection are also discussed.
Results and discussion
This study found that: (1) the cumulative dose of CB-NPs was greater than that of TiO2-NPs in human lungs; (2) there is a potential health risk to workers exposed to TiO2-NPs and CB-NPs in the absence of control measures in the workplace, with higher health risks associated with CB-NPs than TiO2-NPs; and (3) the use of a ventilating system and an N95 respirator offers greater protection in the workplace and significantly reduces the health risks associated with NP exposure.
The present risk management control strategy suggests that the most effective way to reduce airborne NPs is to incorporate the use of a ventilating system combined with N95 respirator protection. This will enable the concentrations of TiO2-NPs and CB-NPs to be reduced to acceptable exposure levels.
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Ahlers J, Riedhammer C, Vogliano M, Ebert RU, Kuhne R, Schuurmann G (2006) Acute to chronic ratios in aquatic toxicity—variation across trophic levels and relationship with chemical structure. Environ Toxicol Chem 25:2937–2945
Bałazy A, Toivola M, Reponen T, Podgorski A, Zimmer A, Grinshpun SA (2006) Manikin-based performance evaluation of N95 filtering-facepiece respirators challenged with nanoparticles. Ann Occup Hyg 50:259–269
Bartis JT, Landree E (2006) Nanomaterials in the workplace: Policy and Planning Workshop on Occupational Safety and Health. Santa Monica: The RAND Corporation, Prepared for the National Institute for Occupational Safety and Health
Bergamaschi E (2009) Occupational exposure to nanomaterials: present knowledge and future development. Nanotoxicology 3:194–201
Brouwer D (2010) Exposure to manufactured nanoparticles in different workplaces. Toxicology 269:120–127
Chen CC, Bai HL, Chein HM, Chen TM (2007) Continuous generation of TiO2 nanoparticles by an atmospheric pressure plasma-enhanced process. Aerosol Sci Technol 41:1018–1028
Chio CP, Liao CM (2008) Assessment of atmospheric ultrafine carbon particle-induced human health risk based on surface area dosimetry. Atmos Environ 42:8575–8584
CIIT Centers for Health Research (2006) Multiple-path particle dosimetry (MPPD) model version 2 software. http://www.ciit.org
Crosera M, Bovenzi M, Maina G et al (2009) Nanoparticle dermal absorption and toxicity: a review of the literature. Int Arch Occup Environ Health 82:1043–1055
ECCHCP (European Commission Community Health and Consumer Protection) (2004) Nanotechnologies: a preliminary risk analysis on the basis of a workshop organized in Brussels on 1–2 March 2004 by the Health and Consumer Protection Directorate General of the European Commission. European Commission Community Health and Consumer Protection, Belgium
Elder A, Gelein R, Finkelstein JN, Driscoll KE, Harkema J, Oberdörster G (2005) Effects of subchronically inhaled carbon black in three species. I. Retention kinetics, lung inflammation, and histopathology. Toxicol Sci 88:614–629
Golanski L, Guiot A, Tardif F (2010) Experimental evaluation of individual protection devices against different types of nanoaerosols: graphite, TiO2, and Pt. J Nanopart Res 12:83–89
Gurr JR, Wang ASS, Chen CH, Jan KY (2005) Ultrafine titanium dioxide particles in the absence of photoactivation can induce oxidative damage to human bronchial epithelial cells. Toxicology 213:66–73
Han JH, Lee EJ, Lee JH et al (2008) Monitoring multiwalled carbon nanotube exposure in carbon nanotube research facility. Inhal Toxicol 20:1–9
Handy RD, Shaw BJ (2007) Toxic effects of nanoparticles and nanomaterials: implications for public health, risk assessment and the public perception of nanotechnology. Health Risk Soc 9:125–144
Hill AV (1910) The possible effects of the aggregation of the molecules of haemoglobin on its dissociation curves. J Physiol 40:i–vii
Huang SH, Chen CW, Yeh WY (2004) Collection of nanoparticles by commercial respirator filters. J Occup Saf Health 12:264–274 (in Chinese)
ICRP (International Commission on Radiological Protection) (1995) Human respiratory tract model for radiological protection. ICRP Publication 66, International Commission on Radiological Protection, New York
IOSH, Taiwan (Institute of Occupational Safety and Health, Taiwan) (2007) Capture efficiency of ventilation system for nanoparticles. Institute of Occupational Safety and Health, Executive Yuan, Taipei
Kim HJ, Han B, Hong WS et al (2010) Development of electrostatic diesel particulate matter filtration systems combined with a metallic flow-through filter and electrostatic methods. Int J Automot Technol 11:447–453
Kuhlbusch TAJ, Neumann S, Fissan H (2004) Number size distribution, mass concentration, and particle composition of PM1, PM2.5, and PM10 in bag filling areas of carbon black production. J Occup Environ Hyg 1:660–671
Liao CM, Chiang YH, Chio CP (2009) Assessing the airborne titanium dioxide nanoparticle-related exposure hazard at workplace. J Hazard Mater 162:57–65
Maynard AD (2003) Estimating aerosol surface area from number and mass concentration measurements. Ann Occup Hyg 47:123–144
Morfeld P, Buchte SF, Wellmann J, McCunney RJ, Piekarski C (2006) Lung cancer mortality and carbon black exposure: Cox regression analysis of a cohort from a German carbon black production plant. J Occup Environ Med 48:1230–1241
Nel A, Xia T, Madler L, Li N (2006) Toxic potential of materials at the nanolevel. Science 311:622–627
Oberdörster G, Finkelstein JN, Johnston C et al (2000) Acute pulmonary effects of ultrafine particles in rats and mice. Health Effects Institute, Cambridge, MA
Oberdörster G, Oberdörster E, Oberdörster (2005) Nanotoxicology: an emerging discipline evolving from studies of ultrafine particles. Environ Health Perspect 113:823–839
Old L, Methner MM (2008) Effectiveness of local exhaust ventilation (LEV) in controlling engineered nanomaterial emissions during reactor cleanout operations. J Occup Environ Hyg 5:D63–69
Pui DYH, Qi CL, Stanley N, Oberdörster G, Maynard A (2008) Recirculating air filtration significantly reduces exposure to airborne nanoparticles. Environ Health Perspect 116:863–866
Pulskamp K, Diabate S, Krug HF (2007) Carbon nanotubes show no sign of acute toxicity but induce intracellular reactive oxygen species in dependence on contaminants. Toxicol Lett 168:58–74
RSRAE (The Royal Society and the Royal Academy of Engineering) (2004) Nanoscience and nanotechnologies: opportunities and uncertainties. The Royal Society and the Royal Academy of Engineering, London
Sager TM, Castranova V (2009) Surface area of particle administered versus mass in determining the pulmonary toxicity of ultrafine and fine carbon black: comparison to ultrafine titanium dioxide. Part Fibre Toxicol 6:1–12
Sayes CM, Wahi R, Kurian PA et al (2006) Correlating nanoscale titania structure with toxicity: a cytotoxicity and inflammatory response study with human dermal fibroblasts and human lung epithelial cells. Toxicol Sci 92:174–185
Schmoll LH, Elzey S, Grassian VH, O'Shaughnessy PT (2009) Nanoparticle aerosol generation methods from bulk powders for inhalation exposure studies. Nanotoxicology 3:265–275
Shaffer RE, Rengasamy S (2009) Respiratory protection against airborne nanoparticles: a review. J Nanopart Res 11:1661–1672
USEPA (US Environment Protection Agency) (1995) Great lakes water quality initiative technical support document for wildlife criteria. EPA-820-B-95-009, Office of Science and Technology, Office of Water, USEPA, Washington DC
Wellmann J, Weiland SK, Neiteler G, Klein G, Straif K (2006) Cancer mortality in German carbon black workers 1976–98. Occup Environ Med 63:513–521
Yang Q, Wang L, Xiang WD, Zhou JF, Tan QH (2007) A temperature-responsive carbon black nanoparticle prepared by surface-induced reversible addition-fragmentation chain transfer polymerization. Polymer 48:3444–3451
The study was financially supported by China Medical University, Taiwan (CMU 96-131).
Responsible editor: Vera Slaveykova
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Ling, MP., Chio, CP., Chou, WC. et al. Assessing the potential exposure risk and control for airborne titanium dioxide and carbon black nanoparticles in the workplace. Environ Sci Pollut Res 18, 877–889 (2011). https://doi.org/10.1007/s11356-011-0447-y
- Titanium dioxide
- Carbon black
- Risk assessment