Skip to main content

Advertisement

SpringerLink
Log in

The effect of 8 weeks of circuit resistance training on serum levels of decorin and IGF-I in sedentary young men

  • Research
  • Published:
Sport Sciences for Health Aims and scope Submit manuscript

Abstract

Purpose

Decorin is a new Myokine that effects of different exercise training on its levels is unknown. The aim of this study was to identify the effect of 8 weeks of circuit resistance training on serum levels of Decorin in young inactive males.

Methods

The 20 overweight young men randomly assigned in 2 groups (n = 10) including control and circuit resistance training group. Circuit resistance training program conducted in 8 weeks and three sessions per week. Each training session consists of nine exercise that performed by 50 to 60 percent of 1RM. Before and after each exercise session, warm up and cooling down performed, respectively. Before (pre-test) and 48 h after last exercise training session (post-test), blood sampling performed to measurement of Decorin levels and data were analyzed by SPSS software and by using analysis of covariance test.

Results

Results indicated the significant increase of Decorin levels in trained groups compared to control group (p < 0.05). However, there are no significant changes in serum levels of growth hormone and IGF-I levels in trained group than control group.

Conclusion

Present study findings indicated that circuit resistance training for 8 weeks could be associated with positive effects and according to present study results, some positive effect of this type of exercise can be attributed to up regulation of Decorin levels.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1

Similar content being viewed by others

Data availability

Supplemental material for this article will be made available on request.

Code availability

Not applicable.

References

  1. Zargani M et al (2021) Sarcopenia: molecular pathways and potential benefits of exercise training. J Exerc Organ Cross Talk 1(3):143–158

    Google Scholar 

  2. Ball D (2015) Metabolic and endocrine response to exercise: sympathoadrenal integration with skeletal muscle. J Endocrinol 224(2):R79–R95

    Article  CAS  PubMed  Google Scholar 

  3. Zargani M et al (2021) Cross-talk between skeletal muscle and placenta during pregnancy: possible effects of exercise training. J Exerc Organ Cross Talk 1(2):100–101

    Google Scholar 

  4. Hartwig S et al (2014) Secretome profiling of primary human skeletal muscle cells. Biochim Biophys Acta Proteins Proteom 1844(5):1011–1017

    Article  CAS  Google Scholar 

  5. Delphan M et al (2021) High intensity interval exercise alters muscle IL-18, FNDC5, and hepatic MMPs in animal model of steatosis: evidence of skeletal muscle—liver crosstalk. J Exerc Organ Cross Talk 1(3):115–123

    Google Scholar 

  6. Pedersen B et al (2003) Searching for the exercise factor: is IL-6 a candidate? J Muscle Res Cell Motil 24(2):113–119

    Article  CAS  PubMed  Google Scholar 

  7. Shirvani H, Rostamkhani F (2020) Exercise considerations during coronavirus disease 2019 (COVID-19) outbreak: a narrative review. J Mil Med 22(2):161–168

    Google Scholar 

  8. Gorzi A, Hosseini F (2021) Muscle and serum antioxidant cross talk following curcumin and light resistance training during strenuous endurance training in male Wistar rats. J Exerc Organ Cross Talk 1(2):86–92

    Google Scholar 

  9. Pedersen L, Hojman P (2012) Muscle-to-organ cross talk mediated by myokines. Adipocyte 1(3):164–167

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  10. Ost M et al (2016) Regulation of myokine expression: role of exercise and cellular stress. Free Radic Biol Med 98:78–89

    Article  CAS  PubMed  Google Scholar 

  11. Tayebi SM et al (2019) Plasma retinol-binding protein-4 and tumor necrosis factor-α are reduced in postmenopausal women after combination of different intensities of circuit resistance training and Zataria supplementation. Sport Sci Health 15(3):551–558

    Article  PubMed  PubMed Central  Google Scholar 

  12. Shirvani H, Aslani J (2017) The effects of high-intensity interval training vs. moderate-intensity continuous training on serum irisin and expression of skeletal muscle PGC-1α gene in male rats. Tehran Univ Med J 75(7):513–520

    Google Scholar 

  13. Chen S, Birk DE (2011) Focus on molecules: decorin. Exp Eye Res 92(6):444

    Article  CAS  PubMed  Google Scholar 

  14. Brandan E, Cabello-Verrugio C, Vial C (2008) Novel regulatory mechanisms for the proteoglycans decorin and biglycan during muscle formation and muscular dystrophy. Matrix Biol 27(8):700–708

    Article  CAS  PubMed  Google Scholar 

  15. Bolton K et al (2008) Decorin is a secreted protein associated with obesity and type 2 diabetes. Int J Obes 32(7):1113–1121

    Article  CAS  Google Scholar 

  16. Schönherr E et al (2005) Decorin, a novel player in the insulin-like growth factor system. J Biol Chem 280(16):15767–15772

    Article  PubMed  Google Scholar 

  17. Mirdar S et al (2019) The effects of tapering with and without ethanolic extract of Nigella sativa on hypoxia inducible factor-1α and exercise-induced bronchial changes. J Mil Med 21(2):131–141

    Google Scholar 

  18. Bahl N et al (2018) Decorin, a growth hormone-regulated protein in humans. Eur J Endocrinol 178(2):145–152

    Article  CAS  PubMed  Google Scholar 

  19. Kanzleiter T et al (2014) The myokine decorin is regulated by contraction and involved in muscle hypertrophy. Biochem Biophys Res Commun 450(2):1089–1094

    Article  CAS  PubMed  Google Scholar 

  20. Xu SY et al (2018) Response of decorin to different intensity treadmill running. Mol Med Rep 17(6):7911–7917

    CAS  PubMed  Google Scholar 

  21. Ghardashi-Afousi A et al (2018) The effects of low-volume high-intensity interval versus moderate intensity continuous training on heart rate variability, and hemodynamic and echocardiography indices in men after coronary artery bypass grafting: a randomized clinical trial study. ARYA Atheroscler 14(6):260

    PubMed  PubMed Central  Google Scholar 

  22. Lee H et al (2021) IGF-1 upregulates biglycan and decorin by increasing translation and reducing ADAMTS5 expression. Int J Mol Sci 22(3):1403

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  23. Suzuki K et al (2013) Decorin activates A kt downstream of IGF-IR and promotes myoblast differentiation. Anim Sci J 84(9):669–674

    Article  CAS  PubMed  Google Scholar 

  24. Kwon JH, Moon KM, Min K-W (2020) Exercise-induced myokines can explain the importance of physical activity in the elderly: an overview. Healthcare. https://doi.org/10.3390/healthcare8040378

    Article  PubMed  PubMed Central  Google Scholar 

  25. Hazley L et al (2010) Impact of a short-term, moderate intensity, lower volume circuit resistance training programme on metabolic risk factors in overweight/obese type 2 diabetics. Res Sports Med 18(4):251–262

    Article  PubMed  Google Scholar 

  26. Ghanbari-Niaki A, Saghebjoo M, Hedayati M (2011) A single session of circuit-resistance exercise effects on human peripheral blood lymphocyte ABCA1 expression and plasma HDL-C level. Regul Pept 166(1–3):42–47

    Article  CAS  PubMed  Google Scholar 

  27. Kishioka Y et al (2008) Decorin enhances the proliferation and differentiation of myogenic cells through suppressing myostatin activity. J Cell Physiol 215(3):856–867

    Article  CAS  PubMed  Google Scholar 

  28. Heinemeier K et al (2013) Expression of extracellular matrix components and related growth factors in human tendon and muscle after acute exercise. Scand J Med Sci Sports 23(3):e150–e161

    Article  CAS  PubMed  Google Scholar 

  29. Bekki M et al (2018) The association between sarcopenia and decorin, an exercise-induced myokine, in patients with liver cirrhosis: a pilot study. JCSM Rapid Commun 1(2):1–10

    Article  Google Scholar 

  30. Li Y et al (2007) Decorin gene transfer promotes muscle cell differentiation and muscle regeneration. Mol Ther 15(9):1616–1622

    Article  CAS  PubMed  Google Scholar 

  31. Knuiman P et al (2018) Plasma cytokine responses to resistance exercise with different nutrient availability on a concurrent exercise day in trained healthy males. Physiol Rep 6(11):e13708

    Article  PubMed  PubMed Central  Google Scholar 

Download references

Funding

None.

Author information

Authors and Affiliations

  1. Exercise Physiology Research Center, Life Style Institute, Baqiyatallah University of Medical Sciences, Tehran, Iran

    Ehsan Arabzadeh

  2. Department of Physical Education and Sport Sciences, Faculty of Literature, Humanities and Social Sciences, Science and Research Branch, Islamic Azad University, Tehran, Iran

    Zahra Ghassemi Gil-kalayeh, Mandana Gholami, Hossein Abed Natanzi & Samaneh Ebrahimi

Authors
  1. Ehsan Arabzadeh
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Zahra Ghassemi Gil-kalayeh
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Mandana Gholami
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Hossein Abed Natanzi
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Samaneh Ebrahimi
    View author publications

    You can also search for this author in PubMed Google Scholar

Contributions

All authors equally conterbute in preperation of this manuscript.

Corresponding author

Correspondence to Mandana Gholami.

Ethics declarations

Conflict of interest

The authors declare no potential conflicts of interest.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee of Islamic Azad University, Tehran, Iran and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards.

Consent for publication

All participants were provided, prior to commencement of the study, with information sheets explaining intent to publish, with option to receive copies of submitted manuscripts.

Additional information

Publisher's Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Arabzadeh, E., Ghassemi Gil-kalayeh, Z., Gholami, M. et al. The effect of 8 weeks of circuit resistance training on serum levels of decorin and IGF-I in sedentary young men. Sport Sci Health 19, 503–509 (2023). https://doi.org/10.1007/s11332-022-01035-7

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s11332-022-01035-7

Keywords

Search

Navigation