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Extreme conditioning session augments brain-derived neurotrophic factor in healthy novice participants: a pilot study

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Abstract

Purpose

To analyze the circulating serum levels of the brain-derived neurotrophic factor (BDNF) in novice participants submitted to an extreme conditioning training session (ECT).

Methods

Ten untrained male subjects were submitted to an ECT session, composed by the protocol "as many repetitions as possible" (WOD-AMRAP). The training session lasted 9 min, including the exercises clean, wall ball throw, and double or single-unders. At the end of the training session, Borg's perceived exertion assessment (RPE, 0–10) was assessed to demonstrate the level of physical requirement. Blood samples were collected baseline and immediately after the ECT session to measure BDNF. The Cohen's d effect size calculation was used to evaluate the magnitude of training effects on the BDNF levels. In addition, Pearson's correlation was applied between training parameters and BDNF acute delta response.

Results

The following results were found: (1) all individuals reported a similar level of effort ([RPE] 8.8 ± 0.78); (2) total training load and total volumes were 1456.4 ± 334.12 kg and 127 ± 28.2 repetitions, respectively; (3) the ratio between total load and the total volume was 11.45 ± 0.21 kg/repetition; (4) the mean BDNF response showed a significant increase (PRE 12,617 ± 2070 vs. POST 13,642 ± 1791 pg/mL, respectively) [ES = 0.49]; 5) no correlation was found between training parameters and BDNF delta acute responses.

Conclusion

Through the results found here, we concluded that a high-density/effort WOD-AMRAP ECT session is able to stimulate the acute increase in serum BDNF levels in novice participants.

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Authors and Affiliations

  1. Department of Physical Education, Laboratory of Morphoquantitative Studies and Immunohistochemistry, São Judas Tadeu University, Rua Taquari, 546, Mooca Unit, P.O Box 03166-000, São Paulo, SP, Brazil

    Emy Suelen Pereira & Walter Krause Neto

  2. Department of Physical Education, Laboratory of Body Perception and Movement, São Judas Tadeu University, São Paulo, SP, Brazil

    Emy Suelen Pereira, Mariana Georgetti & Larissa Guerreiro

  3. Department of Pathology, Faculty of Veterinary Medicine and Animal Science, University of São Paulo, São Paulo, SP, Brazil

    Atilio Sersun Calefi

  4. Department of Physical Education, Laboratory of Human Movement, São Judas Tadeu University, São Paulo, SP, Brazil

    Cesar Augustus Sousa Zocoler

  5. Department of Morphology, Federal University of São Paulo, São Paulo, SP, Brazil

    Eliane Florencio Gama

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  1. Emy Suelen Pereira
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Contributions

EP is the lead author of this manuscript, contributing all its steps, including volunteer training. WKN assisted in the stages of project preparation, statistics, data analysis, and final data preparation. AC collected the data and blood and analyzed the BDNF. MG, LG, and CZ assisted in the assembly of the training protocol, data collection during the volunteers' training, and the final version of the manuscript. EG guided the entire process and was present at all stages.

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Correspondence to Walter Krause Neto.

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All procedures performed in studies involving human participants were approved by the ethical standards of the institutional or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards (protocol 37330614.7.0000.0089).

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Pereira, E.S., Neto, W.K., Calefi, A.S. et al. Extreme conditioning session augments brain-derived neurotrophic factor in healthy novice participants: a pilot study. Sport Sci Health 18, 537–544 (2022). https://doi.org/10.1007/s11332-021-00840-w

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