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Interleukin-15 and creatine kinase response to high-intensity intermittent exercise training

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Abstract

Purpose

To verify the acute and chronic effects of high-intensity intermittent training (HIIT) on interleukin 15 (IL-15) response and the relationship between circulating IL-15 concentrations and muscle damage in young men.

Methods

Physically active men performed two different training protocols at moderate and high intensity, three times per week for 5 weeks. Twenty subjects were randomly allocated into high-intensity intermittent training group (HIIT-5 km 1 min at 100% of maximal aerobic speed interspersed by 1 min passive recovery; n = 10) or moderate-intensity continuous training group (MICT-5 km 70% of maximal aerobic speed; n = 10). An acute exercise session was performed with blood sample collection pre-exercise, immediately post-exercise, and 60 min post-exercise (before and after 5 weeks of training). Blood samples were used to analyze serum IL-15 and creatine kinase (CK) concentrations.

Results

The results showed no changes in serum IL-15 concentrations independent of protocol, moment measurement, and intervention period. CK concentrations showed higher values post-exercise when compared to pre-exercise in both protocols. No significant relationship was found between serum IL-15 and CK concentrations.

Conclusion

Our findings point to the absence of acute and chronic changes in serum IL-15 concentrations in response to 5 weeks of high-intensity intermittent training. In addition, data suggest that the release of this cytokine is not related to muscle damage in healthy young men.

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Acknowledgements

Thaislaine dos Santos would like to thank Fundação de Amparo à Pesquisa do Estado de São Paulo (Fapesp) for their support (2016/12145–1). The authors would like to thank Prof. Dr. Valéria Leme Gonçalves Panissa for the statistical analysis.

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Authors and Affiliations

  1. Exercise and Immunometabolism Research Group, Department of Physical Education, School of Technology and Sciences, São Paulo State University (Unesp), Presidente Prudente, São Paulo, Brazil

    Thaislaine dos Santos, Fabio Santos Lira & Barbara Moura Antunes

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  1. Thaislaine dos Santos
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  2. Fabio Santos Lira
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  3. Barbara Moura Antunes
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Corresponding authors

Correspondence to Thaislaine dos Santos or Fabio Santos Lira.

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The authors declare no conflict of interest.

Ethical approval

The study was approved by the Research Ethics Committee for studies involving human participants at the State University (Unesp) of the Presidente Prudente School of Technology and Sciences/SP (53297815.8.0000.5402).This study complies with the 1964 Helsinki declaration and its later amendments.

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All participants signed a consent form after being informed of the purposes and risks of the study.

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dos Santos, T., Lira, F. & Antunes, B.M. Interleukin-15 and creatine kinase response to high-intensity intermittent exercise training. Sport Sci Health 16, 479–484 (2020). https://doi.org/10.1007/s11332-020-00629-3

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  • DOI: https://doi.org/10.1007/s11332-020-00629-3

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