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Very light physical activity amount in FTO genetically predisposed obese individuals

Abstract

Purpose

Fat mass and obesity-related (FTO) rs9939609 polymorphism has a role in body mass index (BMI) increase and in predisposing to metabolic syndrome (MetS). Our aim was to investigate if a very light physical activity could counteract weight gain and MetS in obese subjects bearing the rs9939609 FTO polymorphism from Southern Italy.

Methods

Data of fitness components, anthropometry, clinical-biochemical parameters and FTO polymorphism in 78 unrelated morbid obese subjects from Southern Italy (15–30 years) were examined. Physical activity energy expenditure was monitored by a SenseWear Pro 3 Armband for 24 h/day for 2 consecutive weekdays in all enrolled individuals.

Results

Sedentary obese subjects had higher waist circumference (124.8 vs 117.9 cm, P < 0.05), BMI (43.4 vs 37.7 kg/m2, P < 0.0001) and fat mass (49.2 vs 44.5%, P < 0.0001) compared to lightly active ones. Further, lightly active obese subjects bearing the rs9939609 FTO minor allele had a lower BMI than polymorphic sedentary ones (37.1 vs 45.3 kg/m2, respectively, P < 0.01), and did not differ in metabolic syndrome presence.

Conclusion

Our results suggest that a very light amount of physical exercise is associated with a lower BMI in obese subjects bearing the minor allele of the rs9939609 FTO polymorphism.

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Funding

Pasqualina Buono was supported by the University of Naples “Parthenope” under grants “Bando per la Ricerca competitiva, triennio 2016-18 quota C” and “Fondo per la ricerca individuale di Ateneo, Annualità 2016″. Grants: Progetto Regione Campania SATIN to Lucia Sacchetti.

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Correspondence to Lucia Sacchetti or Fabrizio Pasanisi.

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Labruna, G., Marra, M., Nardelli, C. et al. Very light physical activity amount in FTO genetically predisposed obese individuals. Sport Sci Health 15, 689–697 (2019). https://doi.org/10.1007/s11332-019-00587-5

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  • DOI: https://doi.org/10.1007/s11332-019-00587-5

Keywords

  • Very light intensity exercise
  • Obesity
  • BMI
  • FTO polymorphism
  • Metabolic syndrome