Sport Sciences for Health

, Volume 14, Issue 2, pp 371–377 | Cite as

Caffeine improves exercise recuperation by cardiovascular and biochemical response in diabetic rats

  • Luiz Augusto da Silva
  • Vinicius Muller Reis Weber
  • Jéssica Wouk
  • Carlos Ricardo Maneck Malfatti
  • Raul Osiecki
Original Article



The objective of this study was to evaluate caffeine effects on cardiovascular and biochemical parameters during the recovering time of aerobic exercise in diabetic rats.

Materials and methods

24 animals of 60 days were allocated to four experimental groups: Control, Diabetic, Caffeine, and Diabetes + Caffeine. Diabetes mellitus was induced by an intraperitoneal administration of 60 mg/kg of alloxan. Once a day for 30 days, animals underwent training of forced swimming for 40 min and tied to loads of 4% of their body weight. On the 1st and 30th days of training, animals underwent a stress test, in which they performed 60 min of forced swimming with loads of 6% session of 6% of their body’s weight. Caffeine was administrated 30 min before the exercise at the test days. Cardiovascular responses such as systolic blood pressure (SBP), heart rate (HR), and double product (DP) were recorded before and after the tests. In addition, blood samples were collected for glucose, glycerol, and lactate analyses, by caudal puncture.


Glucose values were lower in rats of group caffeine + diabetes when compared to animals of other groups (25%; p < 0.05). After caffeine intake, the values of HR, SBP, and DP of diabetic groups increased when compared to control groups (32%).


The present work demonstrated that caffeine intake associated with aerobic exercise might control glucose levels in healthy and diabetic rats. Caffeine was able to reduce glycemic values, regulate cardiovascular responses, and maintain nutrients’ availability during exercise, which may improve overall fitness and tissues’ adaptation to better function.


Metabolism Heart rate Glucose 



The authors are thankful to CAPES (Brazil) and Fundação Araucaria of Paraná (Brazil) for the financial support to this study.

Compliance with ethical standards

Conflict of interest

There are no issues to disclose. There is no potential conflict of interest.

Ethical approval

All procedures performed in studies involving animals were in accordance with the ethical standards of the institutional. All experimental procedures in this study were approved by the Institutional Ethics Committee on Animal Use (protocol no. 015/2015).

Informed consent

For this type of study formal consent is not required.


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Copyright information

© Springer-Verlag Italia S.r.l., part of Springer Nature 2018

Authors and Affiliations

  1. 1.Faculdade Guairacá, Physical Education CollegiateGuairacá CollegeGuarapuavaBrazil
  2. 2.Midwest State University of ParanáGuarapuavaBrazil
  3. 3.Federal University of ParanáCuritibaBrazil

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