Sport Sciences for Health

, Volume 14, Issue 2, pp 455–457 | Cite as

The rise of lactic acid, from a pharmacist’s laboratory to entry into the central nervous system

  • Maria Cristina Petralia
  • Valentina Perciavalle
  • Maria Sofia Basile
  • Giovanna Alagona
  • Aldo Monaca
  • Andrea Buscemi
  • Marinella Coco
Short Communication


Brief historical review of lactic acid: since its discovery in the laboratory of Scheele, passing the role in muscle and systemically observed by scientists Friherre Jons Jakob Berzelius, Araki, Meyerhof, Margaria, Cori until joining and role in the Nervous System Central by scientists Davis, Brooks, Connet, Richardson, Donovan, Magistretti and Pellerin.


Lactate Central nervous system History of medicine 


Compliance with ethical standards


Authors state that they have not received funding for this study.

Conflict of interest

The authors declared no conflict of interests.

Ethical approval

All procedures performed in studies involving human participants were in accordance with ethical standards of the institutional and national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

Informed consent

For this type of study formal consent is not required.


  1. 1.
    Robergs RA, Ghiasvand F, Parker D (2004) Biochemistry of exercise-induced metabolic acidosis. Am J Physiol Regul Integr Comp Physiol 287(3):R502–R516CrossRefPubMedGoogle Scholar
  2. 2.
    Gladden LB (2008) 200th anniversary of lactate research in muscle. Exerc Sport Sci Rev 36(3):109–115CrossRefPubMedGoogle Scholar
  3. 3.
    Noakes TD, St Clair Gibson A (2004) Logical limitations to the “catastrophe” models of fatigue during exercise in humans. Br J Sports Med 38(5):648–649CrossRefPubMedPubMedCentralGoogle Scholar
  4. 4.
    Margaria R et al (1933) The possible mechanisms of contracting and paying the oxygen debt and the role of lactic acid in muscular contraction. Am J Physiol 106:689–715Google Scholar
  5. 5.
    Coco M (2017) The brain behaves as the muscle? Neurol Sci. Google Scholar

Copyright information

© Springer-Verlag Italia S.r.l., part of Springer Nature 2018

Authors and Affiliations

  1. 1.Department of Biomedical and Biotechnological SciencesUniversity of CataniaCataniaItaly
  2. 2.Department of Educational SciencesUniversity of CataniaCataniaItaly
  3. 3.Department of NeurologyCannizzaro Hospital, CataniaCataniaItaly
  4. 4.Polytechnic of the SeaCataniaItaly
  5. 5.Horus Cooperative SocialRagusaItaly

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