The rise of lactic acid, from a pharmacist’s laboratory to entry into the central nervous system
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Brief historical review of lactic acid: since its discovery in the laboratory of Scheele, passing the role in muscle and systemically observed by scientists Friherre Jons Jakob Berzelius, Araki, Meyerhof, Margaria, Cori until joining and role in the Nervous System Central by scientists Davis, Brooks, Connet, Richardson, Donovan, Magistretti and Pellerin.
KeywordsLactate Central nervous system History of medicine
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The authors declared no conflict of interests.
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- 4.Margaria R et al (1933) The possible mechanisms of contracting and paying the oxygen debt and the role of lactic acid in muscular contraction. Am J Physiol 106:689–715Google Scholar