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A Mendelian randomization study revealed a causal link between napping and deep vein thrombosis (DVT)

  • Sleep Breathing Physiology and Disorders • Original Article
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Abstract

Background

Numerous individuals opt for napping to achieve adequate rest, and several studies have linked napping to various health conditions. Consequently, we aimed to investigate the potential effect of napping on the development of deep vein thrombosis (DVT).

Methods

We used the publicly available summary statistics data sets of genome‐wide association studies (GWAS) meta‐analyses for napping in individuals included in the UK Biobank as the exposure and a GWAS for DVT from the individuals included in the FinnGen Biobank as the outcome. The two-sample MR research approach was utilized to explore the causative link between napping and DVT. Single nucleotide polymorphisms (SNPs) data strongly related to napping were found and used as instrumental factors. Inverse variance weighting (IVW), weighted median and MR-Egger regression, and weighted mode approaches were four statistical techniques.

Results

There were 86 SNPs in all that were discovered to be strongly related to napping (P < 5 × 10−8, linkage disequilibrium r2 < 0.1). Consistent association between napping and DVT (IVW: odds ratio (OR) 0.508, 95% confidence interval (CI) 0.280–0.921; MR-Egger regression: OR 0.988, 95% CI 0.118–8.303; weighted median estimates: OR 0.419, 95% CI 0.181–0.974; weighted mode: OR 0.442, 95% CI 0.080–2.427) suggested that napping correlated with decreased risk of DVT. There was no evidence that genetic pleiotropy affected the link between napping and DVT (MR-Egger intercept − 6.7 × 10−3; P = 0.525).

Conclusion

The results of the Mendelian randomization study suggested a potential causal relationship between napping and a reduced incidence of DVT.

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Data availability

Our data are publicly available at the following URL: http://app.mrbase.org/.

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Authors and Affiliations

  1. Department of Thoracic Surgery, The Seventh Affiliated Hospital, Sun Yat-Sen University, 628 Zhenyuan Rd, Shenzhen, 518107, China

    Dongqing Yan, Gengqiu Liu, Yin Yin, Qiwei Zhang, Donglei Shi, Junhang Zhang & Yun Li

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  1. Dongqing Yan
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  2. Gengqiu Liu
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  3. Yin Yin
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  4. Qiwei Zhang
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  7. Yun Li
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Correspondence to Dongqing Yan.

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Yan, D., Liu, G., Yin, Y. et al. A Mendelian randomization study revealed a causal link between napping and deep vein thrombosis (DVT). Sleep Breath 28, 665–671 (2024). https://doi.org/10.1007/s11325-023-02940-y

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  • DOI: https://doi.org/10.1007/s11325-023-02940-y

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