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Role of vitamin D in the association between pre-stroke sleep quality and poststroke depression and anxiety

  • Neurology • Original Article
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Abstract

Purpose

Poor sleep quality, mood disorders, and vitamin D deficiency are common in stroke. We investigated the association between serum vitamin D levels and pre-stroke sleep quality and the occurrence of poststroke depression (PSD) and poststroke anxiety (PSA) in acute ischemic stroke (AIS).

Methods

This prospective cross-sectional study included hospitalized patients with AIS and age- and sex-matched controls. Vitamin D levels were measured within 24 h of admission. Sleep quality was assessed using the Pittsburgh Sleep Quality Index (PSQI) at admission. The severity of depression and anxiety symptoms was evaluated according to Beck Depression Inventory and Beck Anxiety Inventory scores, respectively, within 72 h after admission.

Results

Comparing 214 AIS patients with 103 controls, patients had significantly higher scores of Beck Depression Inventory, Beck Anxiety Inventory, and PSQI and lower vitamin D levels (p < 0.001). Among AIS patients, Beck Depression Inventory (p = 0.004) and Beck Anxiety Inventory (p = 0.018) scores were significantly higher in bad sleepers (PSQI score ≥ 6) than in good sleepers (PSQI score ≤ 5). Correlation analysis revealed negative correlations between serum vitamin D levels and Beck Depression Inventory (r =  − 0.234; p < 0.001), Beck Anxiety Inventory (r =  − 0.135; p = 0.016), and PSQI (r =  − 0.218; p < 0.001) scores.

Conclusion

Decreased serum vitamin D levels at admission are associated with a high risk for PSD and PSA in patients with poor pre-stroke sleep quality during the early stages of AIS.

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Data availability

Researchers can apply for access to anonymized data from the present study for well‐defined research questions that are in line with the overall research agenda for the cohort. Please contact the corresponding author.

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Authors and Affiliations

  1. Department of Neurology, Kirsehir Ahi Evran University Faculty of Medicine, Kirsehir, 40100, Turkey

    Celikbilek Asuman & Koysuren Aydan

  2. Department of Biostatistics and Medical Informatics, Kirsehir Ahi Evran University Faculty of Medicine, Kirsehir, Turkey

    Konar Naime Meric

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  1. Celikbilek Asuman
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Correspondence to Celikbilek Asuman.

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Asuman, C., Aydan, K. & Meric, K.N. Role of vitamin D in the association between pre-stroke sleep quality and poststroke depression and anxiety. Sleep Breath (2023). https://doi.org/10.1007/s11325-023-02894-1

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