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Serum uric acid is related to left ventricular geometry and function in patients with obstructive sleep apnea

  • Sleep Breathing Physiology and Disorders • Original Article
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Abstract

Introduction

Serum uric acid (SUA) is an oxidative stress-related biomarker of cardiovascular risk. We sought to discover whether or not SUA was related to left ventricular geometry (LVG) and function among individuals with obstructive sleep apnea (OSA).

Methods

Patients with OSA and healthy controls were assessed for clinical features, echocardiography, polysomnography, and blood biochemical data. Patients with OSA were divided into four groups: normal geometry (NG), concentric remodeling (CR), eccentric hypertrophy (EH), and concentric hypertrophy (CH). Correlations of SUA with left ventricular (LV) structure and function were examined through Pearson correlation analysis. The risk variables of LVG were investigated using a multivariate logistic regression model.

Results

Compared to controls, patients with OSA had greater SUA levels. The eccentric hypertrophy (EH) and concentric hypertrophy (CH) groups showed substantially greater SUA levels than the normal geometry (NG) and concentric remodeling (CR) groups (p < 0.05). SUA correlated positively with left ventricular mass index (LVMI) and relative wall thickness (RWT) but negatively with the E/A ratio, according to the Pearson correlation analysis. SUA independently affected EH (OR = 1.021, 95%CI = 1.015–1.028, p < 0.001) and CH (OR = 1.034, 95%CI = 1.025–1.043, p < 0.001) in patients with OSA by the multivariate logistic regression model.

Conclusions

Patients with OSA had elevated levels of SUA, which were seen to be closely linked with abnormal LVG and function. The findings suggest that SUA may raise the risk of LV structural and functional impairment in patients with OSA.

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Data availability

The datasets are available from the corresponding author upon reasonable request.

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Funding

Financial support was received from the Shanxi Provincial Natural Science Foundation of China (201901D111361).

Author information

Authors and Affiliations

  1. Department of Medical Imaging, Shanxi Medical University, Taiyuan, Shanxi, China

    Wen Shui, Tong Cui & Caihong Kang

  2. Department of Ultrasound, First Hospital of Shanxi Medical University, NO.85 Jiefang Nan Road, Taiyuan, 030001, Shanxi, China

    Jian Wang

  3. Department of Respiratory, First Hospital of Shanxi Medical University, Taiyuan, Shanxi, China

    Zhenxia Zhang

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  1. Wen Shui
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Contributions

WS designed research and draft preparation; JW designed research and reviewed the manuscript; ZXZ performed PSG technology; TC and CHK carried out the image acquisition; WS, TC, and CHK image acquisition. The final submission has been checked and approved by all contributors.

Corresponding author

Correspondence to Jian Wang.

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Ethical approval

Approval was obtained from the ethics committee of Shanxi Medical University First Hospital (No. K-ZK024). The procedures used in this study adhere to the tenets of the Declaration of Helsinki.

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All research participants provided informed consent.

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The authors declare no competing interests.

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Shui, W., Wang, J., Cui, T. et al. Serum uric acid is related to left ventricular geometry and function in patients with obstructive sleep apnea. Sleep Breath 27, 1743–1751 (2023). https://doi.org/10.1007/s11325-022-02771-3

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  • DOI: https://doi.org/10.1007/s11325-022-02771-3

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