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Is obstructive sleep apnea associated with increased arterial stiffness in patients with COPD?

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Abstract

Purpose

To evaluate arterial stiffness, a predictor of vascular damage was assessed by means of pulse wave velocity (PWV) in patients with chronic obstructive pulmonary disease (COPD) and comorbid obstructive sleep apnea (OSA), namely overlap syndrome (OS).

Methods

Consecutive stable patients with COPD were evaluated for OSA by means of overnight polysomnography in the laboratory. A clinical assessment was performed according to a strict protocol, including two COPD questionnaires: the COPD assessment test and the modified Medical Research Council scale. COPD severity was graded according to the guidelines of the Global Initiative for Chronic Obstructive Lung Disease. Arterial stiffness was assessed by means of PWV, using a standard technique.

Results

Of 102 patients with COPD, 51 had associated OSA. The OS group had more men than the COPD group (73% vs. 47%, respectively; p < 0.01). Both groups had similar ages (66.2 ± 9.2 years vs. 69.6 ± 10.7, p = 0.09) and airflow limitation (p = 0.37). Hypertension was found in 22% of COPD patients, as opposed to 17% patients in the OS group (p = 0.29). High PWV values were present in 42% of the patients. Patients with COPD and OS had the same PWV values (9.8 vs. 10.5 m/s, p = 0.34). There were no differences in central blood pressure, peripheral blood pressure, and augmentation index between the two groups (p > 0.05).

Conclusion

High PWV values were frequently observed in patients with COPD. However, there was no difference in PWV between patients with OS and those with COPD alone.

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Fig. 1

Data availability

The datasets generated and/or analyzed during the current study are available from the corresponding author on request.

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Funding

This study was financed in part by the Coordenação de Aperfeiçoamento de Pessoal de Nível Superior, Brasil (CAPES)—grant protocol no. 307386/2018–0.

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Authors and Affiliations

  1. Pulmonology Clinic, Hospital Otávio de Freitas, Rua Aprígio Guimarães s/n, Pernambuco, Tejipió, Recife, Brazil

    Danielle Cristina Silva Clímaco

  2. Laboratório Do Sono E Coração, Pronto Socorro Cardiológico de Pernambuco, (PROCAPE) da Universidade de Pernambuco, Rua dos Palmares, s/n, Santo Amaro, Recife, Brazil

    Danielle Cristina Silva Clímaco, Thais C. Lustosa, Marcus Vinícius de F.P., Ozeas L. Lins-Filho, Marília Montenegro Cabral & Rodrigo P. Pedrosa

  3. Hospital Universitário Oswaldo Cruz, Rua Arnóbio Marques, s/n, Pernambuco, Santo Amaro, Recife, Brazil

    Valesca Kehrle Rodrigues, Luiz de Albuquerque P. de Oliveira Neto & Fernando José Pinho Queiroga Júnior

  4. Pronto Socorro Cardiológico de Pernambuco (PROCAPE) da Universidade de Pernambuco, Rua dos Palmares, s/n, Santo Amaro, Recife, Brazil

    Audes Diógenes Magalhães Feitosa & Rodrigo P. Pedrosa

Authors
  1. Danielle Cristina Silva Clímaco
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  2. Thais C. Lustosa
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  3. Marcus Vinícius de F.P.
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  4. Ozeas L. Lins-Filho
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  5. Valesca Kehrle Rodrigues
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  6. Luiz de Albuquerque P. de Oliveira Neto
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  7. Audes Diógenes Magalhães Feitosa
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  8. Fernando José Pinho Queiroga Júnior
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  9. Marília Montenegro Cabral
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  10. Rodrigo P. Pedrosa
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Corresponding author

Correspondence to Danielle Cristina Silva Clímaco.

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Ethics approval

All procedures performed in this study were done in accordance with the ethical standards of the Complexo Hospitalar, Hospital Universitário Oswaldo Cruz, Universidade de Pernambuco/UPE/Procape; protocol number 68781017.3.0000.5192, and the 1964 Helsinki declaration, as amended.

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Informed consent had been obtained from all participants included in the study.

Conflict of interest

The authors declare that they have no conflict of interest.

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Clímaco, D.C.S., Lustosa, T.C., de F.P., M.V. et al. Is obstructive sleep apnea associated with increased arterial stiffness in patients with COPD?. Sleep Breath 27, 765–770 (2023). https://doi.org/10.1007/s11325-022-02635-w

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  • DOI: https://doi.org/10.1007/s11325-022-02635-w

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