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The effect of continuous positive airway pressure treatment on inflammatory parameters and periostin levels in patients with obstructive sleep apnea syndrome

  • Sleep Breathing Physiology and Disorders • Original Article
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Abstract

Background

The purpose of the study was to examine the effects of continuous positive airway pressure (CPAP) treatment on inflammation parameters in patients with obstructive sleep apnea syndrome (OSAS).

Methods

Patients aged 18 to 65 years who underwent polysomnography (PSG) in the sleep clinic between January 1, 2019, and December 31, 2019, were included in the study. Patients with severe OSAS initiated treatment with CPAP. Patients and control subjects were assessed for levels of periostin, TNF-alpha, TGF-beta, and IL-6. Patients were re-evaluated 3 months later. Comparisons for the serum markers were made between controls and patients of different severity of OSAS. Comparisons of serum markers were also made between baseline and 3 month follow-up. 

Results

A total of 92 patients were enrolled in the study, including 25 controls (apnea-hypopnea index or AHI < 5/h), 39 patents with mild to moderate OSAS who did not receive CPAP, and 28 patients with severe OSAS receiving CPAP treatment. When all three groups were compared, levels of periostin, TNF-alpha, TGF-beta, and IL-6, as inflammatory markers, were higher in the OSAS group, though not at a statistically significant level. In patients with severe OSAS, there were statistically significant decreases in the TGF-beta 1, TNF-alpha, and IL-6 values between baseline values and the same measures taken after 3 months of CPAP treatment. Periostin values also decreased after treatment, but this decrease was not at a significant level.

Conclusion

Inflammatory parameters of patients with OSAS were significantly higher compared with healthy participants. Regression of inflammation was detected after CPAP treatment.

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Data availability

All data generated or analyzed during this study are included in this published article (and its supplementary information files).

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Funding

Our study was supported by the Hatay Mustafa Kemal University Scientific Research Projects Coordinator (Project Number: 19.U.013).

Author information

Authors and Affiliations

  1. Department of Chest Diseases, Faculty of Medicine, Hatay Mustafa Kemal University, Tayfur Sökmen (31060) Campus, Alahan-Antakya, 31060, Hatay, Turkey

    Fatma Tosun, Cenk Babayiğit & Nursel Dikmen

  2. Department of Biochemistry, Faculty of Medicine, Hatay Mustafa Kemal University, Antakya, Hatay, Turkey

    Serdar Doğan

  3. Department of Biostatistics, Faculty of Medicine, Hatay Mustafa Kemal University, Antakya, Hatay, Turkey

    Emre Dirican

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  1. Fatma Tosun
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The manuscript has been read and approved by all the authors. The requirements for authorship as stated earlier in this document have been met and each author believes that the manuscript represents honest work.

Corresponding author

Correspondence to Nursel Dikmen.

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Ethics approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards. Confirmation of the Local Ethics Committee was obtained. Our study was approved by the Ethics Committee of Mustafa Kemal University Faculty of Medicine (Date and Number: 2019/54). The purpose of our study was explained to the participants in detail, and informed by Helsinki rules, and consent was obtained.

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Informed consent was obtained from all individual participants included in the study.

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The authors declare no competing interests.

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Tosun, F., Babayiğit, C., Dikmen, N. et al. The effect of continuous positive airway pressure treatment on inflammatory parameters and periostin levels in patients with obstructive sleep apnea syndrome. Sleep Breath 27, 275–282 (2023). https://doi.org/10.1007/s11325-022-02616-z

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  • DOI: https://doi.org/10.1007/s11325-022-02616-z

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