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Pulmonary disease and periodontal health: a meta-analysis

  • Sleep Breathing Physiology and Disorders • Original Article
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Abstract

Objective

Research has shown a positive relationship between pulmonary and periodontal disease. However, the relationship remains unclear. The aim of this meta-analysis was to evaluate the associations between pulmonary disease and periodontal health.

Materials and methods

MEDLINE, PubMed, EMBASE, Web of Science, Science Citation Index, Wanfang, and CNKI were searched for all the relevant studies of relationship between pulmonary disease and periodontal health. Weighted mean difference (WMD)/odds ratio (OR) with 95% confidence interval (CI) was used to assess the strength of the association.

Results

Thirty-seven studies were included in this meta-analysis. Pooled analysis showed a significant association between pulmonary and periodontal disease (adjusted OR, 1.93; 95%CI: 1.60–2.33; P < 0.05), and pooled adjusted OR was 1.64, 3.03, and 2.21 in COPD, asthma, and pneumonia, respectively. The pooled analysis also showed that patients with pulmonary disease suffered from worse periodontal health as most periodontal indexes in those patients were poorer.

Conclusions

There is a strong association between pulmonary disease and periodontal health. Clinical trials analyzing the causality and pathological basis of the association of these two diseases are needed.

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Abbreviations

COPD:

Chronic obstructive pulmonary disease

WMD:

Weighted mean difference

CI:

Confidence interval

OR:

Odds ratio

NOS:

Newcastle-Ottawa quality assessment scale

OHI:

Oral hygiene index

RT:

Remaining teeth

ABL:

Level of alveolar bone loss

PD:

Probing depth

SBI:

Sulcus bleeding index

CAL:

Clinical attachment loss

PI:

Plaque index

GI:

Gingival index

BOP:

Bleeding on probing

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  1. Department of Emergency, Affiliated Hangzhou First People’s Hospital, Zhejiang University School of Medicine, No. 261 HuanSha Road, Hangzhou, 310006, China

    ZeSheng Wu, Chen Xiao, FangHui Chen, Yi Wang & ZhiDong Guo

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Wu, Z., Xiao, C., Chen, F. et al. Pulmonary disease and periodontal health: a meta-analysis. Sleep Breath 26, 1857–1868 (2022). https://doi.org/10.1007/s11325-022-02577-3

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