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Choroidal vascularity index in obstructive sleep apnea syndrome

  • Sleep Breathing Physiology and Disorders • Original Article
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Abstract

Background

There is growing evidence supporting an association between obstructive sleep apnea syndrome (OSAS) and systemic vascular disorders. However, the data on choroidal microvasculature are limited. In recent years, choroidal thickness (CT) and choroidal vascularity index (CVI) have been of considerable interest as objective markers of choroidal vascularity. We hypothesized that the imbalance of vascular regulation in OSAS may adversely affect the CT and CVI and may help to assess the vascular risk in these patients.

Purpose

This study aimed to evaluate the choroidal morphology in patients with OSAS.

Materials and methods

Patients with moderate OSAS were included to this study. The subfoveal, nasal, and temporal CT were calculated. The choroidal area (CA) was binarized to the luminal area (LA) and stromal area (SA) using ImageJ software. The CVI was calculated as the proportion of the LA to the total CA.

Results

Of 40 eyes of 40 patients, the mean subfoveal CT was significantly decreased in the OSAS group in comparison to the controls (p = 0.032). The mean CA, LA, and SA were decreased in the OSAS group compared with the controls, but the differences did not reach a statistical significance (p = 0.132, p = 0.104, and p = 0.184, respectively). The CVI was not significantly changed in patients with OSAS (p = 1.000).

Conclusion

Unlike CT, there were no significant differences in choroidal structural parameters and CVI in patients with OSAS.

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Authors and Affiliations

  1. Department of Ophthalmology, Kırşehir Training and Research Hospital, Kırşehir, Turkey

    Gökçen Özcan, Emine Temel & Nazife Aşıkgarip

  2. Department of Ophthalmology, Kırşehir Ahi Evran University School of Medicine, Kırşehir, Turkey

    Kemal Örnek & Özkan Kocamış

  3. Department of Chest Diseases, Kırşehir Ahi Evran University School of Medicine, Kırşehir, Turkey

    Nermin Zerman & Arzu Ertürk

Authors
  1. Gökçen Özcan
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  2. Emine Temel
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  3. Kemal Örnek
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  4. Nermin Zerman
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  5. Nazife Aşıkgarip
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  6. Özkan Kocamış
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  7. Arzu Ertürk
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Corresponding author

Correspondence to Emine Temel.

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Ethics approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. This study was approved by the Medical Ethical Committee of the Ahi Evran University Faculty of Medicine (2021–11/127).

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The authors declare no competing interests.

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Özcan, G., Temel, E., Örnek, K. et al. Choroidal vascularity index in obstructive sleep apnea syndrome. Sleep Breath 26, 1655–1659 (2022). https://doi.org/10.1007/s11325-021-02538-2

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  • DOI: https://doi.org/10.1007/s11325-021-02538-2

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