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Changes in platelet count and coagulation parameters in children with obstructive sleep apnea

  • Pediatrics • Original Article
  • Published:
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Abstract

Objective

To investigate the correlation between obstructive sleep apnea (OSA) and coagulation status and to speculate on the underlying mechanism in children with OSA.

Methods

We divided 345 children with OSA (age 2–14 years) into four groups according to the apnea–hypopnea index (AHI). We compared platelet (PLT) and coagulation parameters among groups. Correlations between the polysomnography parameters and coagulation parameters were investigated.

Results

Children with OSA had higher PLT counts than those without OSA (P < 0.001), while no significant difference was observed in prothrombin time, international normalized ratio, activated partial thromboplastin time, thrombin time, or fibrinogen among children with/without OSA. In linear regression analysis, the AHI and oxygen desaturation index (ODI) presented positive correlation with the PLT count (R2 = 0.155, beta = 0.307, P < 0.001 and R2 = 0.113, beta = 0.262, P < 0.001), and there was no correlation among the AHI, ODI, and other coagulation parameters. The minimum and mean oxygen saturation of arterial blood manifested negative correlation with the PLT count (R2 = 0.076, beta =  − 0.116, P = 0.034 and R2 = 0.083, beta =  − 0.140, P = 0.008, respectively).

Conclusions

Children with OSA have a higher PLT count, positively correlated with OSA severity, and no evidence of coagulation disorder.

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Funding

This work was partly supported by the Post-doctoral Research and Development Fund project of Sichuan University (NO. 2019HXBH093; Jing Wang).

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Author notes

    Authors and Affiliations

    1. Department of Otorhinolaryngology Head and Neck Surgery, West China Hospital, Sichuan University, Chengdu, Sichuan, China

      Tian Shen, Jing Wang, Linke Li, Yixin Qiao, Xiaohong Yan, Jian Zou & Yu Zhao

    2. Department of Otorhinolaryngology Head and Neck Surgery, Chengdu Shangjin Nanfu Hospital, West China Hospital, Sichuan University, Chengdu, Sichuan, China

      Min Chen

    3. Sleep Medicine Center, West China Hospital, Sichuan University, Chengdu, Sichuan, China

      Xiangdong Tang

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    1. Tian Shen
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    2. Jing Wang
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    Correspondence to Jian Zou or Yu Zhao.

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    Ethical approval

    This study was approved by the Ethics Committee of West China Hospital of Sichuan University (No.2018–146).

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    Informed consent was obtained from all patients.

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    The authors declare no competing interests.

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    Tian Shen and Jing Wang contributed equally as first authors. Yu Zhao and Jian Zou contributed equally as corresponding authors.

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    Cite this article

    Shen, T., Wang, J., Li, L. et al. Changes in platelet count and coagulation parameters in children with obstructive sleep apnea. Sleep Breath 26, 871–878 (2022). https://doi.org/10.1007/s11325-021-02443-8

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    • DOI: https://doi.org/10.1007/s11325-021-02443-8

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