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Alterations of oral microbiota in patients with obstructive sleep apnea–hypopnea syndrome treated with continuous positive airway pressure: a pilot study

  • Sleep Breathing Physiology and Disorders • Short Communication
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Abstract

Purpose

Obstructive sleep apnea–hypopnea syndrome (OSAHS) is an independent risk factor for cardiovascular diseases, including hypertension. In our previous study, it was demonstrated that oral microbiota alteration in patients with OSAHS, particularly in the genera Aggregatibacter and Porphyromonas, may influence the development of hypertension. Continuous positive airway pressure (CPAP) is the main therapy for OSAHS and OSAHS-associated hypertension. However, the role of oral microbiota post CPAP treatment remains unknown.

Methods

We conducted 16S rDNA pyrosequencing and bioinformatic analyses to compare the bacterial composition of oral specimens from patients with OSAHS before and after overnight CPAP treatment.

Results

This approach enabled a relatively comprehensive description of oral microbiota, with decreases in Gemella and increases in Staphylococcus, f_Lachnospiraceae, Parabacteroides, and f_Ruminococcaceae after CPAP treatment.

Conclusion

Alteration of oral microbiota may shed new insight on the underlying pathogenesis of OSAHS-associated hypertension.

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Acknowledgements

We thank all the participants and their families who took part in this study.

Funding

This study was funded by the academic funding of the Second Affiliated Hospital of Fujian Medical University (grant number BS201902).

Author information

Author notes

  1. Ko and Hu contributed equally to this paper

  2. Ko and Zeng are co-corresponding authors and have contributed equally to this work

Authors and Affiliations

  1. Department of Respiratory and Critical Care Medicine, The Second Affiliated Hospital of Fujian Medical University, No. 34, Zhongshanbei Rd, Licheng District, Quanzhou, 362000, Fujian Province, China

    Chih-Yuan Ko, An-Ke Hu, Li Zhang, Xiao-Ling Lu & Yi-Ming Zeng

  2. Department of Clinical Nutrition, The Second Affiliated Hospital of Fujian Medical University, Quanzhou, China

    Chih-Yuan Ko

  3. School of Public Health, Fujian Medical University, Fuzhou, 350122, Fujian, China

    Chih-Yuan Ko

  4. Respiratory Medicine Center of Fujian Province, Quanzhou, China

    Chih-Yuan Ko, Li Zhang, Xiao-Ling Lu & Yi-Ming Zeng

  5. Department of Pulmonary and Critical Care Medicine, Zhongshan Hospital, Xiamen University, Xiamen, China

    An-Ke Hu

Authors
  1. Chih-Yuan Ko
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  2. An-Ke Hu
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  3. Li Zhang
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  4. Xiao-Ling Lu
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  5. Yi-Ming Zeng
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Contributions

Conception and design: CYK and YMZ. Acquisition of data: CYK and AKH. Analysis and interpretation of data: LXL, and LZ. Drafting or revision of the article: CYK, AKH, YMZ. Final approval of the manuscript: all authors read and approved the final manuscript.

Corresponding authors

Correspondence to Chih-Yuan Ko or Yi-Ming Zeng.

Ethics declarations

Ethics approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. The present study was approved by the second affiliated hospital of Fujian medical university’s institutional review board (IRB No. 2017–78).

Conflict of interest

The authors declare no competing interest.

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Ko, CY., Hu, AK., Zhang, L. et al. Alterations of oral microbiota in patients with obstructive sleep apnea–hypopnea syndrome treated with continuous positive airway pressure: a pilot study. Sleep Breath 26, 811–814 (2022). https://doi.org/10.1007/s11325-021-02428-7

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  • DOI: https://doi.org/10.1007/s11325-021-02428-7

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