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Assessing the effect of nicotine dose in cigarette smoking on sleep quality

  • Sleep Breathing Physiology and Disorders • Original Article
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Abstract

Background

While several studies assessed the relation between cigarette smoking and sleep, there are still very few studies assessing the effect of nicotine in cigarette smoking on sleep.

Aim

This study aimed to compare higher vs lower nicotine levels in cigarette smoking on sleep quality.

Methods

We used data from the recently released dataset for the Randomized Trial of Reduced-Nicotine Standards for Cigarettes. We included three groups in the current study: the least nicotine concentration (i.e., 0.4 mg/g), a moderate nicotine concentration (i.e., 5.2 mg/g), and the highest nicotine concentration (i.e., 15.8 mg/g). For each participant, we included data regarding baseline and the last follow up at 6 weeks, where we compared insomnia, sleep problems, and awakening at night, in addition to different depression and affect scores.

Results

A total of 360 patients were included in this study, with a mean age of 42.4 (±13.4) years. For the three nicotine groups (i.e., 0.4 mg/g, 5.2 mg/g, and 15.8 mg/g), we included 119 (33%), 122 (34%), and 119 (33%) participants. Among the high-nicotine-dose group, the number of participants who had worsened sleep was significantly higher than the number of those who had improved sleep (p = 0.01) after 6 weeks of consumption, where 37 (31%) had worsened sleep score after 6 weeks while only 19 (16%) had improved score compared with baseline.

Conclusion

While previous studies established a relation either between cigarette smoking and sleep or between nicotine patches and sleep, the present study is the first to establish that higher nicotine doses in cigarettes were associated with more sleep disturbances.

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Data availability

The data used in this study is available at the National Institute on Drug Abuse (NIDA) data share website: https://datashare.nida.nih.gov/study/nidacenicp1s1?fbclid=IwAR3ZLh85fSq9cQbTDmJNuihJh3HXaMXhW8qmxsCjZCpKOOlTcL-wYKtbyXw

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Authors and Affiliations

  1. Department of Special Surgery, The University of Jordan, Amman, 11942, Jordan

    Saif Aldeen AlRyalat

  2. Department of Pediatrics, The University of Jordan, Amman, 11942, Jordan

    Sara Kussad

  3. Department of Internal Medicine, The University of Jordan, Amman, 11942, Jordan

    Osama El Khatib

  4. Hashemite University, Amman, Jordan

    Ibrahim Hamad

  5. The University of Jordan, Amman, 11942, Jordan

    Ahmad AL-Tanjy, Mahmoud Alshnneikat & Basma AbuMahfouz

Authors
  1. Saif Aldeen AlRyalat
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  2. Sara Kussad
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  3. Osama El Khatib
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  4. Ibrahim Hamad
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  5. Ahmad AL-Tanjy
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  6. Mahmoud Alshnneikat
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  7. Basma AbuMahfouz
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Contributions

Study design: SAA. Research concept: SAA, AAT MA BA. Literature review: SK OEK IH AAT MA BA. Statistical analysis: SAA. Drafting: SK OEK IH AAT MA BA. Revision of manuscript: SAA. Approval of final manuscript: All authors.

Corresponding author

Correspondence to Saif Aldeen AlRyalat.

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The authors declare that they have no conflict of interest.

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Exempted as the study used open access data.

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AlRyalat, S.A., Kussad, S., El Khatib, O. et al. Assessing the effect of nicotine dose in cigarette smoking on sleep quality. Sleep Breath 25, 1319–1324 (2021). https://doi.org/10.1007/s11325-020-02238-3

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  • DOI: https://doi.org/10.1007/s11325-020-02238-3

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