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Circulating C3 and glucose metabolism abnormalities in patients with OSAHS

  • Sleep Breathing Physiology and Disorders • Original Article
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Abstract

Purpose

Obstructive sleep apnea hypopnea syndrome (OSAHS) is a common breathing disorder during sleep characterized by multiple disease roots, including disorders of complement and glycometabolism. And the main purpose of the present study is to make clear the effect of complement C3 on glucose metabolism abnormalities in patients with OSAHS.

Methods

This was a cross-sectional study. Two hundred six patients, mean age 44.58 ± 11.84 years and 26 female patients (26/206), had been suspected with OSAHS and underwent overnight polysomnography. The assessment of complement levels included complement 3 (C3), complement 4 (C4), and serum total complement (TC). The measured indicators of glucose metabolism were fasting blood glucose (FPG), fasting insulin (FINS), and 75 g oral glucose tolerance test-derived glucose. A multivariate linear regression was used to determine relevant factors with 2-h postprandial blood glucose (2hPG) and C3.

Results

The patients were classified according to apnea-hypopnea index (AHI) into four groups: simple snore (n = 21), mild OSAHS (n = 43), moderate OSAHS (n = 35), and severe OSAHS (n = 107). The level of C3 in the severe OSAHS was higher than other groups (simple snore: 1.16 ± 0.18 g/L VS 1.00 ± 0.18 g/L, p < 0.001; mild OSAHS: 1.16 ± 0.18 g/L VS 1.04 ± 0.17 g/L, p < 0.001; moderate OSAHS: 1.16 ± 0.18 g/L VS 1.06 ± 0.14 g/L, p = 0.003) and no-severe OSAHS group (1.16 ± 0.18 g/L VS 1.04 ± 0.16 g/L, p < 0.001). And C3 was associated with AHI, average pulse oxygen saturation (A-spo2), homeostasis model assessment-insulin resistance (HOMA-IR), 2hPG, age, sleep stage (I + II)/TST, and sleep stage (III)/TST, respectively. HOMA-IR was correlated to AHI after adjustment with age and BMI. OSAHS was an independent risk of C3 regardless of obesity and sleep parameters (p = 0.002). After adjustment with neck circumference (NC), BMI, AHI, sleep stage (I + II)/TST, and sleep stage (III)/TST,C3 level was associated with 2hPG (p < 0.001).

Conclusions

A high level in C3 is correlated with the occurrence of OSAHS and C3 alterations in OSAHS patients seem to contribute to disorders of glucose metabolism. And targeting OSAHS to improve glucose metabolism and immune function could be useful.

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Funding

No funding was received for this research.

Author information

Authors and Affiliations

  1. Sleep Medicine Center, Nanfang Hospital, Southern Medical University, Guangzhou, China

    Xiaoxia Lu, Xiao Wang, Ting Xu, Yuan Feng, Yufeng Wang, Zechuan Cai & Taoping Li

  2. Second People’s Hospital of Yunnan Province, Kunming, China

    Bing Cao

Authors
  1. Xiaoxia Lu
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  2. Xiao Wang
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  3. Ting Xu
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  4. Yuan Feng
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  5. Yufeng Wang
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  6. Zechuan Cai
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  7. Bing Cao
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  8. Taoping Li
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Contributions

Dr. Li contributed to data analysis, exchange of ideas, and review of the manuscript for important content. Ms. Lu contributed to data collection, data analysis and interpretation, and drafting and review of the manuscript for important content. Dr. Wang X and Dr. Xu contributed to data collection and interpretation and review and drafting of manuscript. Dr. Feng contributed to data analysis and review of the manuscript. Mr. Wang YF and Mr. Cai contributed to data collection and analysis. Dr. Cao contributed to exchange of ideas and suggestions.

Corresponding author

Correspondence to Taoping Li.

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Ethical approval

All procedures performed in the studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

Informed consent

Informed consent was obtained from all individual participants included in the study.

Conflict of interest

The authors declare that they have no conflict of interest.

Additional information

The current work was performed at Southern Hospital, Southern Medical University.

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Lu, X., Wang, X., Xu, T. et al. Circulating C3 and glucose metabolism abnormalities in patients with OSAHS. Sleep Breath 22, 345–351 (2018). https://doi.org/10.1007/s11325-017-1564-8

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  • DOI: https://doi.org/10.1007/s11325-017-1564-8

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